Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?

Sutton naevi can sometimes present a challenging appearance with atypical presentation, also by dermoscopy. Reflectance confocal microscopy could help in making a diagnosis. This study prospectively collected two groups of Sutton nevi: the first one was composed by typical white halo naevi monitored...

Full description

Bibliographic Details
Authors: Brugués, Albert, Ribero, Simone, Martins da Silva, Vanessa, Aguilera, Paula, García Herrera, Adriana, Alós i Hernández, Llúcia, Malvehy, J. (Josep), Puig i Sardà, Susana, Carrera Álvarez, Cristina
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172565
Online Access:https://hdl.handle.net/2445/172565
Access Level:Open access
Keyword:Melanoma
Diagnòstic
Microscòpia confocal
Diagnosis
Confocal microscopy
id ES_71e8866a779b3515a3bfb9d2ff279e17
oai_identifier_str oai:recercat.cat:2445/172565
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?Brugués, AlbertRibero, SimoneMartins da Silva, VanessaAguilera, PaulaGarcía Herrera, AdrianaAlós i Hernández, LlúciaMalvehy, J. (Josep)Puig i Sardà, SusanaCarrera Álvarez, CristinaMelanomaDiagnòsticMicroscòpia confocalMelanomaDiagnosisConfocal microscopySutton naevi can sometimes present a challenging appearance with atypical presentation, also by dermoscopy. Reflectance confocal microscopy could help in making a diagnosis. This study prospectively collected two groups of Sutton nevi: the first one was composed by typical white halo naevi monitored for one year (13, 23%) and the second one was made up of atypical lesions excised in order to rule out melanoma, which were histologically diagnosed as Sutton naevi (21, 37%). These two groups of Sutton naevi were compared to a retrospectively collected cohort of thin melanomas with histologic regression features (23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reflectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction: marked dermo-epidermal junction thickening and non-edged papilla were associated with melanoma, while the presence of nests was associated with Sutton naevi. However, reflectance confocal microscopy also detected marked intraepidermal pagetoid cells in Sutton naevi that were a combination of MelanA+ and CD1a+ cells. Sutton naevi can simulate melanoma, under both dermoscopy and reflectance confocal microscopy. Nevertheless, relevant confocal dermo-epidermal junction features and the clinical scenario can be helpful to make a final diagnosis, especially in those situations where melanoma must be ruled out.Society for the Publication of Acta Dermato-Venereologica2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/172565Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2340/00015555-3488Acta Dermato-Venereologica, 2020, vol. 100, num. 10, p. adv00134https://doi.org/10.2340/00015555-3488(c) Brugués, Albert et al., 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1725652026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
title Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
spellingShingle Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
Brugués, Albert
Melanoma
Diagnòstic
Microscòpia confocal
Melanoma
Diagnosis
Confocal microscopy
title_short Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
title_full Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
title_fullStr Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
title_full_unstemmed Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
title_sort Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
dc.creator.none.fl_str_mv Brugués, Albert
Ribero, Simone
Martins da Silva, Vanessa
Aguilera, Paula
García Herrera, Adriana
Alós i Hernández, Llúcia
Malvehy, J. (Josep)
Puig i Sardà, Susana
Carrera Álvarez, Cristina
author Brugués, Albert
author_facet Brugués, Albert
Ribero, Simone
Martins da Silva, Vanessa
Aguilera, Paula
García Herrera, Adriana
Alós i Hernández, Llúcia
Malvehy, J. (Josep)
Puig i Sardà, Susana
Carrera Álvarez, Cristina
author_role author
author2 Ribero, Simone
Martins da Silva, Vanessa
Aguilera, Paula
García Herrera, Adriana
Alós i Hernández, Llúcia
Malvehy, J. (Josep)
Puig i Sardà, Susana
Carrera Álvarez, Cristina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Melanoma
Diagnòstic
Microscòpia confocal
Melanoma
Diagnosis
Confocal microscopy
topic Melanoma
Diagnòstic
Microscòpia confocal
Melanoma
Diagnosis
Confocal microscopy
description Sutton naevi can sometimes present a challenging appearance with atypical presentation, also by dermoscopy. Reflectance confocal microscopy could help in making a diagnosis. This study prospectively collected two groups of Sutton nevi: the first one was composed by typical white halo naevi monitored for one year (13, 23%) and the second one was made up of atypical lesions excised in order to rule out melanoma, which were histologically diagnosed as Sutton naevi (21, 37%). These two groups of Sutton naevi were compared to a retrospectively collected cohort of thin melanomas with histologic regression features (23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reflectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction: marked dermo-epidermal junction thickening and non-edged papilla were associated with melanoma, while the presence of nests was associated with Sutton naevi. However, reflectance confocal microscopy also detected marked intraepidermal pagetoid cells in Sutton naevi that were a combination of MelanA+ and CD1a+ cells. Sutton naevi can simulate melanoma, under both dermoscopy and reflectance confocal microscopy. Nevertheless, relevant confocal dermo-epidermal junction features and the clinical scenario can be helpful to make a final diagnosis, especially in those situations where melanoma must be ruled out.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172565
url https://hdl.handle.net/2445/172565
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2340/00015555-3488
Acta Dermato-Venereologica, 2020, vol. 100, num. 10, p. adv00134
https://doi.org/10.2340/00015555-3488
dc.rights.none.fl_str_mv (c) Brugués, Albert et al., 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Brugués, Albert et al., 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for the Publication of Acta Dermato-Venereologica
publisher.none.fl_str_mv Society for the Publication of Acta Dermato-Venereologica
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410686222729216
score 15,812429

Similar Items