Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up

Anosognosia in Alzheimer's disease (AD) has been associated with greater cognitive impairment and more behavioural and psychological symptoms of dementia (BPSD). This study examines the incidence, persistence, and remission rates of anosognosia over a 12-month period, as well as the related ris...

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Autores: Turró-Garriga, Oriol, Garre Olmo, Josep, Calvó Perxas, Laia, Reñé Ramírez, Ramon, Gascón-Bayarri, Jordi, Conde Sala, Josep Lluís
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/107268
Acesso em linha:https://hdl.handle.net/2445/107268
Access Level:acceso abierto
Palavra-chave:Malaltia d'Alzheimer
Mètode longitudinal
Demència
Alzheimer's disease
Longitudinal method
Dementia
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spelling Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-upTurró-Garriga, OriolGarre Olmo, JosepCalvó Perxas, LaiaReñé Ramírez, RamonGascón-Bayarri, JordiConde Sala, Josep LluísMalaltia d'AlzheimerMètode longitudinalDemènciaAlzheimer's diseaseLongitudinal methodDementiaAnosognosia in Alzheimer's disease (AD) has been associated with greater cognitive impairment and more behavioural and psychological symptoms of dementia (BPSD). This study examines the incidence, persistence, and remission rates of anosognosia over a 12-month period, as well as the related risk factors. This was an observational 12-month prospective study. The longitudinal sample comprised 177 patients with mild or moderate AD, and their respective caregivers. Anosognosia was assessed using the Anosognosia Questionnaire in Dementia, and we also evaluated cognitive status (Mini-Mental State Examination), functional disability (Disability Assessment in Dementia), and the presence of BPSD (Neuropsychiatric Inventory). Multinomial logistic regression was used to determine the variables associated with the incidence, persistence and remission of anosognosia. The prevalence of anosognosia was 39.5% (95% CI = 32.1-47.1) at baseline. At 12 months, incidence was 38.3% (95% CI = 28.6-48.0), persistence was 80.0% (95% CI = 69.9-90.1) and remission was 20.0% (95% CI = 9.9-30.1). The regression model identified lower age, more education, and the presence of delusions as variables associated with incidence, and more education, lower instrumental DAD score, and disinhibition as variables associated with persistence. No variables were associated with remission (n = 14). The presence of anosognosia in AD patients is high. Education and certain neuropsychiatric symptoms may explain a greater and earlier incidence of anosognosia. However, anosognosia also increases with greater cognitive impairment and disease severityIOS Press2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/107268Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3233/JAD-150706Journal of Alzheimer's Disease, 2016, vol. 51, num. 2, p. 357-366https://doi.org/10.3233/JAD-150706(c) Turró-Garriga, O. et al., 2016info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1072682026-05-29T05:05:01Z
dc.title.none.fl_str_mv Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
title Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
spellingShingle Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
Turró-Garriga, Oriol
Malaltia d'Alzheimer
Mètode longitudinal
Demència
Alzheimer's disease
Longitudinal method
Dementia
title_short Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
title_full Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
title_fullStr Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
title_full_unstemmed Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
title_sort Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
dc.creator.none.fl_str_mv Turró-Garriga, Oriol
Garre Olmo, Josep
Calvó Perxas, Laia
Reñé Ramírez, Ramon
Gascón-Bayarri, Jordi
Conde Sala, Josep Lluís
author Turró-Garriga, Oriol
author_facet Turró-Garriga, Oriol
Garre Olmo, Josep
Calvó Perxas, Laia
Reñé Ramírez, Ramon
Gascón-Bayarri, Jordi
Conde Sala, Josep Lluís
author_role author
author2 Garre Olmo, Josep
Calvó Perxas, Laia
Reñé Ramírez, Ramon
Gascón-Bayarri, Jordi
Conde Sala, Josep Lluís
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Mètode longitudinal
Demència
Alzheimer's disease
Longitudinal method
Dementia
topic Malaltia d'Alzheimer
Mètode longitudinal
Demència
Alzheimer's disease
Longitudinal method
Dementia
description Anosognosia in Alzheimer's disease (AD) has been associated with greater cognitive impairment and more behavioural and psychological symptoms of dementia (BPSD). This study examines the incidence, persistence, and remission rates of anosognosia over a 12-month period, as well as the related risk factors. This was an observational 12-month prospective study. The longitudinal sample comprised 177 patients with mild or moderate AD, and their respective caregivers. Anosognosia was assessed using the Anosognosia Questionnaire in Dementia, and we also evaluated cognitive status (Mini-Mental State Examination), functional disability (Disability Assessment in Dementia), and the presence of BPSD (Neuropsychiatric Inventory). Multinomial logistic regression was used to determine the variables associated with the incidence, persistence and remission of anosognosia. The prevalence of anosognosia was 39.5% (95% CI = 32.1-47.1) at baseline. At 12 months, incidence was 38.3% (95% CI = 28.6-48.0), persistence was 80.0% (95% CI = 69.9-90.1) and remission was 20.0% (95% CI = 9.9-30.1). The regression model identified lower age, more education, and the presence of delusions as variables associated with incidence, and more education, lower instrumental DAD score, and disinhibition as variables associated with persistence. No variables were associated with remission (n = 14). The presence of anosognosia in AD patients is high. Education and certain neuropsychiatric symptoms may explain a greater and earlier incidence of anosognosia. However, anosognosia also increases with greater cognitive impairment and disease severity
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/107268
url https://hdl.handle.net/2445/107268
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3233/JAD-150706
Journal of Alzheimer's Disease, 2016, vol. 51, num. 2, p. 357-366
https://doi.org/10.3233/JAD-150706
dc.rights.none.fl_str_mv (c) Turró-Garriga, O. et al., 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Turró-Garriga, O. et al., 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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