Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21

4 pag.-4 tab.

Detalles Bibliográficos
Autores: Casado Moragón, Ángela, López-Fernández, M.E., Ruíz, Rocío
Tipo de recurso: artículo
Fecha de publicación:2007
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/76126
Acceso en línea:http://hdl.handle.net/10261/76126
Access Level:acceso abierto
Palabra clave:Down syndrome
Free radicals
Lipid peroxidation
Malondialdehyde
Oxidative stress
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spelling Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21Casado Moragón, ÁngelaLópez-Fernández, M.E.Ruíz, RocíoDown syndromeFree radicalsLipid peroxidationMalondialdehydeOxidative stress4 pag.-4 tab.Background: It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids. Methods: We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis revealed 90 individuals with regular trisomy 21, four individuals with trisomy 21 by Robertsonian (Rb) translocation, and six individuals with mosaic trisomy 21. DS individuals were divided into six age groups. The control group consisted of 100 healthy individuals of both sexes (40 males and 60 females) who were age-matched with DS subjects. Results: No significant differences were found in erythrocyte MDA levels between the sexes in any of the age groups for the DS group and the control group. We confirmed significantly higher erythrocyte levels of MDA in individuals with DS compared to the control group. A significant difference was observed in erythrocyte MDA levels between DS individuals with trisomy and controls for all age groups, and in individuals with DS due to Rb translocation trisomy. However, in DS individuals with mosaicism, MDA levels depended on the percentage of diploid and trisomy cells. Conclusions: Our results confirm an increase in lipid peroxidation in patients with DS. © 2007 by Walter de Gruyter.This research project was supported by Foundation Inocente, Inocente, and was rewarded with the Ramón Trias Fargas award for research on Down syndromePeer ReviewedWalter de Gruyter2013201320072013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/76126reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1515/CCLM.2007.011info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/761262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
title Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
spellingShingle Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
Casado Moragón, Ángela
Down syndrome
Free radicals
Lipid peroxidation
Malondialdehyde
Oxidative stress
title_short Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
title_full Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
title_fullStr Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
title_full_unstemmed Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
title_sort Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
dc.creator.none.fl_str_mv Casado Moragón, Ángela
López-Fernández, M.E.
Ruíz, Rocío
author Casado Moragón, Ángela
author_facet Casado Moragón, Ángela
López-Fernández, M.E.
Ruíz, Rocío
author_role author
author2 López-Fernández, M.E.
Ruíz, Rocío
author2_role author
author
dc.subject.none.fl_str_mv Down syndrome
Free radicals
Lipid peroxidation
Malondialdehyde
Oxidative stress
topic Down syndrome
Free radicals
Lipid peroxidation
Malondialdehyde
Oxidative stress
description 4 pag.-4 tab.
publishDate 2007
dc.date.none.fl_str_mv 2007
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/76126
url http://hdl.handle.net/10261/76126
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1515/CCLM.2007.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Walter de Gruyter
publisher.none.fl_str_mv Walter de Gruyter
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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