Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona

Introduction: The osteoporosis was defined in the year 1993 as a systemic squeleton disease caraterized by a reduced bonemass and a bone tissue microarquitecture deterioration.<br/>The reduced bone mass is a typical anomaly of osteoporosis. The other anomaly observed is the derangement of norm...

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Author: Checa Vizcaíno, Miguel Ángel
Format: doctoral thesis
Status:Published version
Publication Date:2003
Country:España
Institution:CBUC, CESCA
Repository:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/4599
Online Access:http://www.tdx.cat/TDX-0701104-160134
http://hdl.handle.net/10803/4599
Access Level:Open access
Keyword:Estrógenos
Densitometría
Osteoporosis
Ciències de la Salut
616.7
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spelling Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de BarcelonaCheca Vizcaíno, Miguel ÁngelEstrógenosDensitometríaOsteoporosisCiències de la Salut616.7Introduction: The osteoporosis was defined in the year 1993 as a systemic squeleton disease caraterized by a reduced bonemass and a bone tissue microarquitecture deterioration.<br/>The reduced bone mass is a typical anomaly of osteoporosis. The other anomaly observed is the derangement of normal microarchitecture<br/>petter. There is a less number of bone trabeculae in the osteoporotic bone and the trabecules are thiner than regular ones; there are as well horizontal backups that are not linked with other structures and therefore they do not give any structural support.The doble source energy radiologic densitometry (DEXA) is the gold standard for the bone mass measurement. The transdermic hormonal replacement therapy prevents bonemass loss.<br/>Objectives: Main: Estimation of the needed interval between two densitometries so real differences show up between two consecutive densitometries.<br/>Secondary: Evaluation of recognizable risk factors for bone mass loss between two consecutive densitometries, stablish differences when progesterone is added and economic cost assesement.<br/>Pacients and Methods: Prospective cohort study in which 3826 postmenopausal patients where included and entered the inclusion criteria, to whom a densitometry was made within the period of January 1994 and December1995. A control group of 2393 patients, a group which received transdermical strogens of 807 patients and a group which received Strogens and progesterone of 626 patients. All where folowed up for a maximun period of 5 years being made an annul DEXA.<br/>Results: Lumbar bone L1-L4. Treatment with strogens OR: 0.472 IC95% (0.389-0.572); Age > 55 years OR: 0.618 IC95% (0.534-0.715); Body Mass Index OR: 0.604 IC95% (0.525-0.694) Menopause>45 años OR: 1.300 IC95% (1.118-1.511). Osteopenia in basal DEXA OR: 1.879 IC95% (1.575-2.242); normal in DEXA OR: 2.553 IC95% (2.100-3.105). 1-2 years period from basal DEXA No significative. 2-3 years period from basal DEXA No significative. 3-4 years period OR 1.869 IC95% (1.420-2460). 4-5 years period OR: 2.164 IC95% (1.492-3.138).<br/>Conclusions: DEXA can be done to patients who are under hormonal replacement therapy in periods no shorter than 3 years. Except for the high risk patients, body mass index < 25 or age below 55 years.Universitat Autònoma de BarcelonaCarreras Collado, RamónUniversitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva2011200420032004info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://www.tdx.cat/TDX-0701104-160134http://hdl.handle.net/10803/4599TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAEspañolADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/45992026-06-14T12:46:07Z
dc.title.none.fl_str_mv Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
title Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
spellingShingle Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
Checa Vizcaíno, Miguel Ángel
Estrógenos
Densitometría
Osteoporosis
Ciències de la Salut
616.7
title_short Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
title_full Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
title_fullStr Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
title_full_unstemmed Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
title_sort Evaluación de la densidad mineral osea en la monitorización de la mujer menopausica que realiza tratamiento hormonal sustitutivo, en el area de Barcelona
dc.creator.none.fl_str_mv Checa Vizcaíno, Miguel Ángel
author Checa Vizcaíno, Miguel Ángel
author_facet Checa Vizcaíno, Miguel Ángel
author_role author
dc.contributor.none.fl_str_mv Carreras Collado, Ramón
Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva
dc.subject.none.fl_str_mv Estrógenos
Densitometría
Osteoporosis
Ciències de la Salut
616.7
topic Estrógenos
Densitometría
Osteoporosis
Ciències de la Salut
616.7
description Introduction: The osteoporosis was defined in the year 1993 as a systemic squeleton disease caraterized by a reduced bonemass and a bone tissue microarquitecture deterioration.<br/>The reduced bone mass is a typical anomaly of osteoporosis. The other anomaly observed is the derangement of normal microarchitecture<br/>petter. There is a less number of bone trabeculae in the osteoporotic bone and the trabecules are thiner than regular ones; there are as well horizontal backups that are not linked with other structures and therefore they do not give any structural support.The doble source energy radiologic densitometry (DEXA) is the gold standard for the bone mass measurement. The transdermic hormonal replacement therapy prevents bonemass loss.<br/>Objectives: Main: Estimation of the needed interval between two densitometries so real differences show up between two consecutive densitometries.<br/>Secondary: Evaluation of recognizable risk factors for bone mass loss between two consecutive densitometries, stablish differences when progesterone is added and economic cost assesement.<br/>Pacients and Methods: Prospective cohort study in which 3826 postmenopausal patients where included and entered the inclusion criteria, to whom a densitometry was made within the period of January 1994 and December1995. A control group of 2393 patients, a group which received transdermical strogens of 807 patients and a group which received Strogens and progesterone of 626 patients. All where folowed up for a maximun period of 5 years being made an annul DEXA.<br/>Results: Lumbar bone L1-L4. Treatment with strogens OR: 0.472 IC95% (0.389-0.572); Age > 55 years OR: 0.618 IC95% (0.534-0.715); Body Mass Index OR: 0.604 IC95% (0.525-0.694) Menopause>45 años OR: 1.300 IC95% (1.118-1.511). Osteopenia in basal DEXA OR: 1.879 IC95% (1.575-2.242); normal in DEXA OR: 2.553 IC95% (2.100-3.105). 1-2 years period from basal DEXA No significative. 2-3 years period from basal DEXA No significative. 3-4 years period OR 1.869 IC95% (1.420-2460). 4-5 years period OR: 2.164 IC95% (1.492-3.138).<br/>Conclusions: DEXA can be done to patients who are under hormonal replacement therapy in periods no shorter than 3 years. Except for the high risk patients, body mass index < 25 or age below 55 years.
publishDate 2003
dc.date.none.fl_str_mv 2003
2004
2004
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://www.tdx.cat/TDX-0701104-160134
http://hdl.handle.net/10803/4599
url http://www.tdx.cat/TDX-0701104-160134
http://hdl.handle.net/10803/4599
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat Autònoma de Barcelona
publisher.none.fl_str_mv Universitat Autònoma de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410656968507392
score 15,300724

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