Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation

The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG...

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Bibliographic Details
Authors: Juszczyk, Ewelina, Kulinowski, Piotr, Baran, Ewelina, Birczynski, Artur, Klaja, Jolanta, Majda, Dorota, García Montoya, Encarna, Weglarz, Wladyslaw P., Dorozynski, Przemyslaw
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181477
Online Access:https://hdl.handle.net/2445/181477
Access Level:Open access
Keyword:Polímers
Sistemes d'alliberament de medicaments
Síntesi de fàrmacs
Nanopartícules
Polymers
Drug delivery systems
Drug synthesis
Nanoparticles
Description
Summary:The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, x-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., 'locking' of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.

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