Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens

Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and e...

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Detalhes bibliográficos
Autores: Estrada-Peña, Agustín, Fuente, José de la, Cabezas-Cruz, Alejandro
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/171933
Acesso em linha:http://hdl.handle.net/10261/171933
Access Level:Acceso aberto
Palavra-chave:Ticks
Networks
Communities
Tick-borne pathogens
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spelling Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogensEstrada-Peña, AgustínFuente, José de laCabezas-Cruz, AlejandroTicksNetworksCommunitiesTick-borne pathogensTicks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches that impact pathogen circulation. The analysis of tick-hosts association suggested that mammals and lizards were the ancestral hosts of this tick species, and that a leap to Aves occurred around 120 M years ago. The signature of the environmental variables over the host's phylogeny revealed the existence of two clades of vertebrates diverging along a temperature and vegetation split. This is a robust proof that the tick probably experienced a colonization of new niches by adapting to a large set of new hosts, Aves. Interestingly, the colonization of Aves as hosts did not increase significantly the ecological niche of I. ricinus, but remarkably Aves are super-spreaders of pathogens. The disparate contribution of Aves to the tick-host-pathogen networks revealed that I. ricinus evolved to maximize habitat overlap with some hosts that are super-spreaders of pathogens. These results supported the hypothesis that large host networks are not a requirement of tick survival but pathogen circulation. The biological cost of tick adaptation to non-optimal environmental conditions might be balanced by molecular mechanisms triggered by the pathogens that we have only begun to understand.Parts of this work were conducted in the framework of the EurNegVec COST Action TD1303. Parts of this research were supported by the EU FP7 ANTIGONE project number 278976.Peer ReviewedFrontiers MediaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820172018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/171933reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/278976https://doi.org/10.3389/fcimb.2017.00234Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1719332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
title Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
spellingShingle Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
Estrada-Peña, Agustín
Ticks
Networks
Communities
Tick-borne pathogens
title_short Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
title_full Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
title_fullStr Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
title_full_unstemmed Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
title_sort Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
dc.creator.none.fl_str_mv Estrada-Peña, Agustín
Fuente, José de la
Cabezas-Cruz, Alejandro
author Estrada-Peña, Agustín
author_facet Estrada-Peña, Agustín
Fuente, José de la
Cabezas-Cruz, Alejandro
author_role author
author2 Fuente, José de la
Cabezas-Cruz, Alejandro
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ticks
Networks
Communities
Tick-borne pathogens
topic Ticks
Networks
Communities
Tick-borne pathogens
description Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches that impact pathogen circulation. The analysis of tick-hosts association suggested that mammals and lizards were the ancestral hosts of this tick species, and that a leap to Aves occurred around 120 M years ago. The signature of the environmental variables over the host's phylogeny revealed the existence of two clades of vertebrates diverging along a temperature and vegetation split. This is a robust proof that the tick probably experienced a colonization of new niches by adapting to a large set of new hosts, Aves. Interestingly, the colonization of Aves as hosts did not increase significantly the ecological niche of I. ricinus, but remarkably Aves are super-spreaders of pathogens. The disparate contribution of Aves to the tick-host-pathogen networks revealed that I. ricinus evolved to maximize habitat overlap with some hosts that are super-spreaders of pathogens. These results supported the hypothesis that large host networks are not a requirement of tick survival but pathogen circulation. The biological cost of tick adaptation to non-optimal environmental conditions might be balanced by molecular mechanisms triggered by the pathogens that we have only begun to understand.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/171933
url http://hdl.handle.net/10261/171933
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/278976
https://doi.org/10.3389/fcimb.2017.00234
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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