Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy

Breast cancer; Fibrosis; Late effects

Detalles Bibliográficos
Autores: Jaikuna, Tanwiwat, Vasquez Osorio, Eliana M, Azria, David, Chang-Claude, Jenny, De Santis, Maria Carmen, Gutiérrez-Enríquez, Sara, Reyes López, Victoria, Seoane Ramallo, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10309
Acceso en línea:https://hdl.handle.net/11351/10309
Access Level:acceso abierto
Palabra clave:Mama - Càncer - Radioteràpia - Complicacions
Mama - Càncer - Cirurgia - Complicacions
Mama - Fibrosi
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis
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oai_identifier_str oai:recercat.cat:11351/10309
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
title Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
spellingShingle Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
Jaikuna, Tanwiwat
Mama - Càncer - Radioteràpia - Complicacions
Mama - Càncer - Cirurgia - Complicacions
Mama - Fibrosi
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis
title_short Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
title_full Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
title_fullStr Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
title_full_unstemmed Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
title_sort Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
dc.creator.none.fl_str_mv Jaikuna, Tanwiwat
Vasquez Osorio, Eliana M
Azria, David
Chang-Claude, Jenny
De Santis, Maria Carmen
Gutiérrez-Enríquez, Sara
Reyes López, Victoria
Seoane Ramallo, Alejandro
author Jaikuna, Tanwiwat
author_facet Jaikuna, Tanwiwat
Vasquez Osorio, Eliana M
Azria, David
Chang-Claude, Jenny
De Santis, Maria Carmen
Gutiérrez-Enríquez, Sara
Reyes López, Victoria
Seoane Ramallo, Alejandro
author_role author
author2 Vasquez Osorio, Eliana M
Azria, David
Chang-Claude, Jenny
De Santis, Maria Carmen
Gutiérrez-Enríquez, Sara
Reyes López, Victoria
Seoane Ramallo, Alejandro
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Jaikuna T] Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Christie NHS Foundation Trust Hospital, Manchester, United Kingdom. Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [Vasquez Osorio E] Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Christie NHS Foundation Trust Hospital, Manchester, United Kingdom. [Azria D] Department of Radiation Oncology, Montpellier Cancer Institute, Université Montpellier, Inserm, France. [Chang-Claude J] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Germany. [De Santis MC] Radiation Oncology, Fondazione IRCCS Isituto Nazionale dei Tumori, Milan, Italy. [Gutiérrez-Enríquez S] Hereditary Cancer Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Seoane A] Servei de Física i Protecció Radiològica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Reyes V] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Mama - Càncer - Radioteràpia - Complicacions
Mama - Càncer - Cirurgia - Complicacions
Mama - Fibrosi
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis
topic Mama - Càncer - Radioteràpia - Complicacions
Mama - Càncer - Cirurgia - Complicacions
Mama - Fibrosi
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Fibrosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosis
description Breast cancer; Fibrosis; Late effects
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10309
url https://hdl.handle.net/11351/10309
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The Breast;72
https://doi.org/10.1016/j.breast.2023.103578
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410642357649408
spelling Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapyJaikuna, TanwiwatVasquez Osorio, Eliana MAzria, DavidChang-Claude, JennyDe Santis, Maria CarmenGutiérrez-Enríquez, SaraReyes López, VictoriaSeoane Ramallo, AlejandroMama - Càncer - Radioteràpia - ComplicacionsMama - Càncer - Cirurgia - ComplicacionsMama - FibrosiDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::Other subheadings::/radiotherapyDISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::FibrosisENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::Otros calificadores::/radioterapiaENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::fibrosisBreast cancer; Fibrosis; Late effectsCàncer de mama; Fibrosi; Efectes tardansCáncer de mama; Fibrosis; Efectos tardíosBackground Normal tissue complication probability (NTCP) models can be useful to estimate the risk of fibrosis after breast-conserving surgery (BCS) and radiotherapy (RT) to the breast. However, they are subject to uncertainties. We present the impact of contouring variation on the prediction of fibrosis. Materials and methods 280 breast cancer patients treated BCS-RT were included. Nine Clinical Target Volume (CTV) contours were created for each patient: i) CTV_crop (reference), cropped 5 mm from the skin and ii) CTV_skin, uncropped and including the skin, iii) segmenting the 95% isodose (Iso95%) and iv) 3 different auto-contouring atlases generating uncropped and cropped contours (Atlas_skin/Atlas_crop). To illustrate the impact of contour variation on NTCP estimates, we applied two equations predicting fibrosis grade 2 at 5 years, based on Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) models, respectively, to each contour. Differences were evaluated using repeated-measures ANOVA. For completeness, the association between observed fibrosis events and NTCP estimates was also evaluated using logistic regression. Results There were minimal differences between contours when the same contouring approach was followed (cropped and uncropped). CTV_skin and Atlas_skin contours had lower NTCP estimates (−3.92%, IQR 4.00, p < 0.05) compared to CTV_crop. No significant difference was observed for Atlas_crop and Iso95% contours compared to CTV_crop. For the whole cohort, NTCP estimates varied between 5.3% and 49.5% (LKB) or 2.2% and 49.6% (RS) depending on the choice of contours. NTCP estimates for individual patients varied by up to a factor of 4. Estimates from “skin” contours showed higher agreement with observed events. Conclusion Contour variations can lead to significantly different NTCP estimates for breast fibrosis, highlighting the importance of standardising breast contours before developing and/or applying NTCP models.REQUITE received funding from the European Union's Seventh Framework Programme for research, technological development, and demonstration under grant agreement no. 601826. We thank all patients who participated in the REQUITE study and all study personnel involved in the REQUITE project. Marianne Aznar acknowledges the support of the Engineering and Physical Sciences Research Council (Grant number EP/T028017/1) This work was supported by Cancer Research UK RadNet Manchester [C1994/A28701] and the NIHR Manchester Biomedical Research Centre (NIHR203308). The researchers at DKFZ also thank Anusha Müller, Irmgard Helmbold, Thomas Heger, Sabine Behrens, Juan Camilo Rosas. Petra Seibold was supported by ERA PerMed 2018 funding (BMBF #01KU1912) and BfS funding (#3619S42261). S. Gutiérrez-Enríquez is supported by the Government of Catalonia 2021SGR01112. The VHIO authors acknowledge the Cellex Foundation for providing research equipment and facilities and thank CERCA Program/Generalitat de Catalunya for institutional support.ElsevierInstitut Català de la Salut[Jaikuna T] Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Christie NHS Foundation Trust Hospital, Manchester, United Kingdom. Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [Vasquez Osorio E] Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Christie NHS Foundation Trust Hospital, Manchester, United Kingdom. [Azria D] Department of Radiation Oncology, Montpellier Cancer Institute, Université Montpellier, Inserm, France. [Chang-Claude J] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Germany. [De Santis MC] Radiation Oncology, Fondazione IRCCS Isituto Nazionale dei Tumori, Milan, Italy. [Gutiérrez-Enríquez S] Hereditary Cancer Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Seoane A] Servei de Física i Protecció Radiològica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Reyes V] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/10309Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThe Breast;72https://doi.org/10.1016/j.breast.2023.103578Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/103092026-05-29T05:05:01Z
score 15,812455

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