Therapeutic potential of articular cartilage regeneration using tissue engineering based on multiphase designs
Articular cartilage tissue possesses poor ability to regenerate; as the lesion progresses, it extends to the underlying subchondral bone and an osteochondral (OC) defect appears complicating the therapeutic approaches. Cartilage tissue engineering has become a very active research area capable of co...
| Autores: | , , , , |
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| Tipo de documento: | capítulo de livro |
| Data de publicação: | 2019 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositório: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglês |
| OAI Identifier: | oai:upcommons.upc.edu:2117/179292 |
| Acesso em linha: | https://hdl.handle.net/2117/179292 https://dx.doi.org/10.5772/intechopen.84697 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Bone regeneration Tissues Osteochondral regeneration Cartilage tissue engineering Multiphasic designs biofunctionalization Vascularization Ossos -- Regeneració Teixits Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| Resumo: | Articular cartilage tissue possesses poor ability to regenerate; as the lesion progresses, it extends to the underlying subchondral bone and an osteochondral (OC) defect appears complicating the therapeutic approaches. Cartilage tissue engineering has become a very active research area capable of contributing to medical technology innovation. In this regard, the development of new biomaterials in combination with cells represents one of the best alternatives for the treatment of OC injuries. In the last decades, the strategies have been designed without considering the cartilage as a complex tissue with a functionally stratified three-dimensional structure. Today, efforts are focused on creating a starting point in the process of cartilage formation with the development of a multiphase implants that recapitulates the cartilage as an OC unit, which improves its integration. This chapter will focus on a review of tissue engineering based on multiphase designs for cartilage and OC injuries, highlighting the importance of the biomaterial selection, and also the relevance of a biomimetic approach to reach a suitable microenvironment for the differentiation and maturation of the chondral tissue. |
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