Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis

The effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications...

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Detalles Bibliográficos
Autores: Fernández Candela, Alba, Calero, Alcia, Sánchez-Guillén, Luis, Escrig-Sos, Javier, Barreras, José A., López Rodríguez -Arias, Francisco, Armanzañas, Laura, Murcia, Ana, Arroyo, Antonio, Lacueva, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38218
Acceso en línea:https://hdl.handle.net/11000/38218
Access Level:acceso abierto
Palabra clave:C-reactive protein
cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)
peritoneal carcinomatosis
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spelling Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal MetastasisFernández Candela, AlbaCalero, AlciaSánchez-Guillén, LuisEscrig-Sos, JavierBarreras, José A.López Rodríguez -Arias, FranciscoArmanzañas, LauraMurcia, AnaArroyo, AntonioLacueva, Francisco JavierC-reactive proteincytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)peritoneal carcinomatosisThe effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications was also analyzed. Patients treated within a peritoneal carcinomatosis program in which a complete or optimal cytoreduction was achieved were retrospectively analyzed. They were divided into two groups based on whether preoperative immunonutrition (IMN) or not (non-IMN) were administered. Clinical and surgical variables and postoperative complications were gathered. Predictive values of major morbidity of CRP during the first 3 postoperative days (POD) were also evaluated. A total of 107 patients were included, 48 belonging to the IMN group and 59 to the non-IMN group. In multivariate analysis immunonutrition (OR 0.247; 95%CI 0.071-0.859; p = 0.028), and the number of visceral resections (OR 1.947; 95%CI 1.086-3.488; p = 0.025) emerged as independent factors associated with postoperative major morbidity. CRP values above 103 mg/L yielded a negative predictive value of 84%. Preoperative intake of immunonutrition was associated with a decrease of postoperative major morbidity and might be recommended to patients with peritoneal carcinomatosis following CRS. Measuring CRP levels during the 3 first postoperative days is useful to rule out major morbidity.MDPIDepartamentos de la UMH::Patología y Cirugía202520252021info:eu-repo/semantics/articleapplication/pdf11application/pdfhttps://hdl.handle.net/11000/38218reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.3390/nu13072147info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/382182026-05-27T13:36:21Z
dc.title.none.fl_str_mv Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
spellingShingle Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
Fernández Candela, Alba
C-reactive protein
cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)
peritoneal carcinomatosis
title_short Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_full Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_fullStr Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_full_unstemmed Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_sort Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
dc.creator.none.fl_str_mv Fernández Candela, Alba
Calero, Alcia
Sánchez-Guillén, Luis
Escrig-Sos, Javier
Barreras, José A.
López Rodríguez -Arias, Francisco
Armanzañas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
author Fernández Candela, Alba
author_facet Fernández Candela, Alba
Calero, Alcia
Sánchez-Guillén, Luis
Escrig-Sos, Javier
Barreras, José A.
López Rodríguez -Arias, Francisco
Armanzañas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
author_role author
author2 Calero, Alcia
Sánchez-Guillén, Luis
Escrig-Sos, Javier
Barreras, José A.
López Rodríguez -Arias, Francisco
Armanzañas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Patología y Cirugía
dc.subject.none.fl_str_mv C-reactive protein
cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)
peritoneal carcinomatosis
topic C-reactive protein
cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC)
peritoneal carcinomatosis
description The effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications was also analyzed. Patients treated within a peritoneal carcinomatosis program in which a complete or optimal cytoreduction was achieved were retrospectively analyzed. They were divided into two groups based on whether preoperative immunonutrition (IMN) or not (non-IMN) were administered. Clinical and surgical variables and postoperative complications were gathered. Predictive values of major morbidity of CRP during the first 3 postoperative days (POD) were also evaluated. A total of 107 patients were included, 48 belonging to the IMN group and 59 to the non-IMN group. In multivariate analysis immunonutrition (OR 0.247; 95%CI 0.071-0.859; p = 0.028), and the number of visceral resections (OR 1.947; 95%CI 1.086-3.488; p = 0.025) emerged as independent factors associated with postoperative major morbidity. CRP values above 103 mg/L yielded a negative predictive value of 84%. Preoperative intake of immunonutrition was associated with a decrease of postoperative major morbidity and might be recommended to patients with peritoneal carcinomatosis following CRS. Measuring CRP levels during the 3 first postoperative days is useful to rule out major morbidity.
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38218
url https://hdl.handle.net/11000/38218
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.3390/nu13072147
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
11
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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