Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates

Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is p...

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Authors: Balanzá Martínez, Vicent, Crespo Facorro, Benedicto|||0000-0001-9709-1276, González Pinto, Ana, Vieta i Pascual, Eduard
Format: article
Publication Date:2015
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/6307
Online Access:http://hdl.handle.net/10902/6307
Access Level:Open access
Keyword:Bipolar disorder
Addiction
Alcohol use disorders
Comorbidity
Neurocognition
Staging
Systems biology
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spelling Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlatesBalanzá Martínez, VicentCrespo Facorro, Benedicto|||0000-0001-9709-1276González Pinto, AnaVieta i Pascual, EduardBipolar disorderAddictionAlcohol use disordersComorbidityNeurocognitionStagingSystems biologyBipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity.FrontiersUniversidad de Cantabria20152015-04-07journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/6307Frontiers in Physiology. 2015 Apr 7;6:108reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/63072026-06-02T12:39:31Z
dc.title.none.fl_str_mv Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
title Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
spellingShingle Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
Balanzá Martínez, Vicent
Bipolar disorder
Addiction
Alcohol use disorders
Comorbidity
Neurocognition
Staging
Systems biology
title_short Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
title_full Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
title_fullStr Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
title_full_unstemmed Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
title_sort Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
dc.creator.none.fl_str_mv Balanzá Martínez, Vicent
Crespo Facorro, Benedicto|||0000-0001-9709-1276
González Pinto, Ana
Vieta i Pascual, Eduard
author Balanzá Martínez, Vicent
author_facet Balanzá Martínez, Vicent
Crespo Facorro, Benedicto|||0000-0001-9709-1276
González Pinto, Ana
Vieta i Pascual, Eduard
author_role author
author2 Crespo Facorro, Benedicto|||0000-0001-9709-1276
González Pinto, Ana
Vieta i Pascual, Eduard
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Bipolar disorder
Addiction
Alcohol use disorders
Comorbidity
Neurocognition
Staging
Systems biology
topic Bipolar disorder
Addiction
Alcohol use disorders
Comorbidity
Neurocognition
Staging
Systems biology
description Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-04-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/6307
url http://hdl.handle.net/10902/6307
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv Frontiers in Physiology. 2015 Apr 7;6:108
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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