Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe

The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal...

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Autores: Mena Cervigón, Marisa, Frias Gomez, Jon, Taberna, Miren, Quirós, Beatriz, Marquez, Sandra, Clavero, Omar, Baena, A., Lloveras Rubio, Betlem, Alejo, Maria, León, X., García, J., Mesía Nin, Ricard, Bermejo, O., Bonfill, T., Aguilà, Anton, Guix, M., Hijano, R., Pavón Ribas, Miquel Àngel, Torres, M., Tous, Sara, Clèries Soler, Ramon, Alemany i Vilches, Laia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171705
Acceso en línea:https://hdl.handle.net/2445/171705
Access Level:acceso abierto
Palabra clave:Papil·lomavirus
Càncer de coll
Epidemiologia
Papillomaviruses
Neck cancer
Epidemiology
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spelling Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern EuropeMena Cervigón, MarisaFrias Gomez, JonTaberna, MirenQuirós, BeatrizMarquez, SandraClavero, OmarBaena, A.Lloveras Rubio, BetlemAlejo, MariaLeón, X.García, J.Mesía Nin, RicardBermejo, O.Bonfill, T.Aguilà, AntonGuix, M.Hijano, R.Pavón Ribas, Miquel ÀngelTorres, M.Tous, SaraClèries Soler, RamonAlemany i Vilches, LaiaPapil·lomavirusCàncer de collEpidemiologiaPapillomavirusesNeck cancerEpidemiologyThe incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe.Nature Research2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/171705Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-020-70118-7Scientific Reports, 2020, vol. 10https://doi.org/10.1038/s41598-020-70118-7cc by (c) Mena Cervigón et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1717052026-05-29T05:05:01Z
dc.title.none.fl_str_mv Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
title Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
spellingShingle Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
Mena Cervigón, Marisa
Papil·lomavirus
Càncer de coll
Epidemiologia
Papillomaviruses
Neck cancer
Epidemiology
title_short Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
title_full Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
title_fullStr Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
title_full_unstemmed Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
title_sort Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
dc.creator.none.fl_str_mv Mena Cervigón, Marisa
Frias Gomez, Jon
Taberna, Miren
Quirós, Beatriz
Marquez, Sandra
Clavero, Omar
Baena, A.
Lloveras Rubio, Betlem
Alejo, Maria
León, X.
García, J.
Mesía Nin, Ricard
Bermejo, O.
Bonfill, T.
Aguilà, Anton
Guix, M.
Hijano, R.
Pavón Ribas, Miquel Àngel
Torres, M.
Tous, Sara
Clèries Soler, Ramon
Alemany i Vilches, Laia
author Mena Cervigón, Marisa
author_facet Mena Cervigón, Marisa
Frias Gomez, Jon
Taberna, Miren
Quirós, Beatriz
Marquez, Sandra
Clavero, Omar
Baena, A.
Lloveras Rubio, Betlem
Alejo, Maria
León, X.
García, J.
Mesía Nin, Ricard
Bermejo, O.
Bonfill, T.
Aguilà, Anton
Guix, M.
Hijano, R.
Pavón Ribas, Miquel Àngel
Torres, M.
Tous, Sara
Clèries Soler, Ramon
Alemany i Vilches, Laia
author_role author
author2 Frias Gomez, Jon
Taberna, Miren
Quirós, Beatriz
Marquez, Sandra
Clavero, Omar
Baena, A.
Lloveras Rubio, Betlem
Alejo, Maria
León, X.
García, J.
Mesía Nin, Ricard
Bermejo, O.
Bonfill, T.
Aguilà, Anton
Guix, M.
Hijano, R.
Pavón Ribas, Miquel Àngel
Torres, M.
Tous, Sara
Clèries Soler, Ramon
Alemany i Vilches, Laia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Càncer de coll
Epidemiologia
Papillomaviruses
Neck cancer
Epidemiology
topic Papil·lomavirus
Càncer de coll
Epidemiologia
Papillomaviruses
Neck cancer
Epidemiology
description The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/171705
url https://hdl.handle.net/2445/171705
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-70118-7
Scientific Reports, 2020, vol. 10
https://doi.org/10.1038/s41598-020-70118-7
dc.rights.none.fl_str_mv cc by (c) Mena Cervigón et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Mena Cervigón et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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