Iron Oxide Nanoparticles in Photothermal Therapy

Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At thi...

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Autores: Estelrich i Latràs, Joan, Busquets i Viñas, Ma. Antonia
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/127277
Acesso em linha:https://hdl.handle.net/2445/127277
Access Level:Acceso aberto
Palavra-chave:Ones electromagnètiques
Terapèutica
Espectroscòpia infraroja
Nanopartícules
Òxid de ferro
Medicaments antineoplàstics
Electromagnetic waves
Therapeutics
Infrared spectroscopy
Nanoparticles
Ferric oxide
Antineoplastic agents
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repository_id_str
spelling Iron Oxide Nanoparticles in Photothermal TherapyEstelrich i Latràs, JoanBusquets i Viñas, Ma. AntoniaOnes electromagnètiquesTerapèuticaEspectroscòpia infrarojaNanopartículesÒxid de ferroMedicaments antineoplàsticsElectromagnetic wavesTherapeuticsInfrared spectroscopyNanoparticlesFerric oxideAntineoplastic agentsPhotothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.MDPI2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/127277Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/molecules23071567Molecules, 2018, vol. 23, p. E1567https://doi.org/10.3390/molecules23071567cc-by (c) Estelrich, Joan et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1272772026-05-27T06:46:51Z
dc.title.none.fl_str_mv Iron Oxide Nanoparticles in Photothermal Therapy
title Iron Oxide Nanoparticles in Photothermal Therapy
spellingShingle Iron Oxide Nanoparticles in Photothermal Therapy
Estelrich i Latràs, Joan
Ones electromagnètiques
Terapèutica
Espectroscòpia infraroja
Nanopartícules
Òxid de ferro
Medicaments antineoplàstics
Electromagnetic waves
Therapeutics
Infrared spectroscopy
Nanoparticles
Ferric oxide
Antineoplastic agents
title_short Iron Oxide Nanoparticles in Photothermal Therapy
title_full Iron Oxide Nanoparticles in Photothermal Therapy
title_fullStr Iron Oxide Nanoparticles in Photothermal Therapy
title_full_unstemmed Iron Oxide Nanoparticles in Photothermal Therapy
title_sort Iron Oxide Nanoparticles in Photothermal Therapy
dc.creator.none.fl_str_mv Estelrich i Latràs, Joan
Busquets i Viñas, Ma. Antonia
author Estelrich i Latràs, Joan
author_facet Estelrich i Latràs, Joan
Busquets i Viñas, Ma. Antonia
author_role author
author2 Busquets i Viñas, Ma. Antonia
author2_role author
dc.subject.none.fl_str_mv Ones electromagnètiques
Terapèutica
Espectroscòpia infraroja
Nanopartícules
Òxid de ferro
Medicaments antineoplàstics
Electromagnetic waves
Therapeutics
Infrared spectroscopy
Nanoparticles
Ferric oxide
Antineoplastic agents
topic Ones electromagnètiques
Terapèutica
Espectroscòpia infraroja
Nanopartícules
Òxid de ferro
Medicaments antineoplàstics
Electromagnetic waves
Therapeutics
Infrared spectroscopy
Nanoparticles
Ferric oxide
Antineoplastic agents
description Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/127277
url https://hdl.handle.net/2445/127277
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/molecules23071567
Molecules, 2018, vol. 23, p. E1567
https://doi.org/10.3390/molecules23071567
dc.rights.none.fl_str_mv cc-by (c) Estelrich, Joan et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Estelrich, Joan et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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