System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function

Background and objective The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling met...

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Autores: Fernández de Cañete Rodríguez, Francisco Javier, Pimentel Naranjo, Víctor, Barbancho Concejero, Julio, Luque Sendra, Amalia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/108827
Acceso en línea:https://hdl.handle.net/11441/108827
https://doi.org/10.1016/j.imu.2019.100164
Access Level:acceso abierto
Palabra clave:System dynamics
Causal diagram modelling
Cardiovascular system
Arterial pressure control
OpenModelica simulation environment
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spelling System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular functionFernández de Cañete Rodríguez, Francisco JavierPimentel Naranjo, VíctorBarbancho Concejero, JulioLuque Sendra, AmaliaSystem dynamicsCausal diagram modellingCardiovascular systemArterial pressure controlOpenModelica simulation environmentBackground and objective The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling methodology based on qualitative reasoning, whereby a conceptual physiological model can be described as a set of cause–effect relationships between the physiological variables of a system, so that a set of dynamic equations describing the system behaviour quantitatively can be derived. Methods This paper presents system dynamics modelling methodology and its application for short-term arterial pressure control exerted through the baroreceptor reflex over a multi-compartmental cardiovascular model under the OpenModelica object-oriented simulation environment. Results The performance of the controlled system is analysed by simulation in light of the existing hypothesis and validation tests previously performed, demonstrating the effectiveness of the short-term regulation mechanism under physiological and pathological conditions.ElsevierTecnología ElectrónicaIngeniería del DiseñoTIC150: Tecnología Electrónica e Informática IndustrialTEP022: Diseño Industrial e Ingeniería del Proyecto y la Innovación2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/108827https://doi.org/10.1016/j.imu.2019.100164reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInformatics in Medicine Unlocked, 15, 100164-.https://www.sciencedirect.com/science/article/pii/S2352914818302545?via%3Dihub#ack0010info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1088272026-06-17T12:51:07Z
dc.title.none.fl_str_mv System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
title System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
spellingShingle System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
Fernández de Cañete Rodríguez, Francisco Javier
System dynamics
Causal diagram modelling
Cardiovascular system
Arterial pressure control
OpenModelica simulation environment
title_short System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
title_full System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
title_fullStr System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
title_full_unstemmed System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
title_sort System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
dc.creator.none.fl_str_mv Fernández de Cañete Rodríguez, Francisco Javier
Pimentel Naranjo, Víctor
Barbancho Concejero, Julio
Luque Sendra, Amalia
author Fernández de Cañete Rodríguez, Francisco Javier
author_facet Fernández de Cañete Rodríguez, Francisco Javier
Pimentel Naranjo, Víctor
Barbancho Concejero, Julio
Luque Sendra, Amalia
author_role author
author2 Pimentel Naranjo, Víctor
Barbancho Concejero, Julio
Luque Sendra, Amalia
author2_role author
author
author
dc.contributor.none.fl_str_mv Tecnología Electrónica
Ingeniería del Diseño
TIC150: Tecnología Electrónica e Informática Industrial
TEP022: Diseño Industrial e Ingeniería del Proyecto y la Innovación
dc.subject.none.fl_str_mv System dynamics
Causal diagram modelling
Cardiovascular system
Arterial pressure control
OpenModelica simulation environment
topic System dynamics
Causal diagram modelling
Cardiovascular system
Arterial pressure control
OpenModelica simulation environment
description Background and objective The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling methodology based on qualitative reasoning, whereby a conceptual physiological model can be described as a set of cause–effect relationships between the physiological variables of a system, so that a set of dynamic equations describing the system behaviour quantitatively can be derived. Methods This paper presents system dynamics modelling methodology and its application for short-term arterial pressure control exerted through the baroreceptor reflex over a multi-compartmental cardiovascular model under the OpenModelica object-oriented simulation environment. Results The performance of the controlled system is analysed by simulation in light of the existing hypothesis and validation tests previously performed, demonstrating the effectiveness of the short-term regulation mechanism under physiological and pathological conditions.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/108827
https://doi.org/10.1016/j.imu.2019.100164
url https://hdl.handle.net/11441/108827
https://doi.org/10.1016/j.imu.2019.100164
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Informatics in Medicine Unlocked, 15, 100164-.
https://www.sciencedirect.com/science/article/pii/S2352914818302545?via%3Dihub#ack0010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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