Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease

Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), cause chronic inflammation of the gut, affecting millions of people worldwide. IBDs have been frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is generally...

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Autores: Chamorro, Nayaret, Montero, David A, Gallardo, Pablo, Farfan, Mauricio, Contreras, Mauricio, De la Fuente, Marjorie, Dubois, Karen, Hermoso, Marcela, Quera, Rodrigo, Pizarro-Guajardo, Marjorie, Paredes-Sabja, Daniel, Ginard Vicens, Daniel, Rossello-Mora, Ramon, Vidal, Roberto
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23342
Acceso en línea:https://hdl.handle.net/20.500.12105/23342
Access Level:acceso abierto
Palabra clave:Mucosa-associated intestinal microbiota
Inflammatory bowel disease
Ulcerative Colitis
Crohn's Disease
Microbiome
Bacterial biomarkers
Dysbiosis
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spelling Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel diseaseChamorro, NayaretMontero, David AGallardo, PabloFarfan, MauricioContreras, MauricioDe la Fuente, MarjorieDubois, KarenHermoso, MarcelaQuera, RodrigoPizarro-Guajardo, MarjorieParedes-Sabja, DanielGinard Vicens, DanielRossello-Mora, RamonVidal, RobertoMucosa-associated intestinal microbiotaInflammatory bowel diseaseUlcerative ColitisCrohn's DiseaseMicrobiomeBacterial biomarkersDysbiosisInflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), cause chronic inflammation of the gut, affecting millions of people worldwide. IBDs have been frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is generally characterized by an increase in abundance of Proteobacteria such as Escherichia coli, and a decrease in abundance of Firmicutes such as Faecalibacterium prausnitzii (an indicator of a healthy colonic microbiota). The mechanisms behind the development of IBDs and dysbiosis are incompletely understood. Using samples from colonic biopsies, we studied the mucosa-associated intestinal microbiota in Chilean and Spanish patients with IBD. In agreement with previous studies, microbiome comparison between IBD patients and non-IBD controls indicated that dysbiosis in these patients is characterized by an increase of pro-inflammatory bacteria (mostly Proteobacteria) and a decrease of commensal beneficial bacteria (mostly Firmicutes). Notably, bacteria typically residing on the mucosa of healthy individuals were mostly obligate anaerobes, whereas in the inflamed mucosa an increase of facultative anaerobe and aerobic bacteria was observed. We also identify potential co-occurring and mutually exclusive interactions between bacteria associated with the healthy and inflamed mucosa, which appear to be determined by the oxygen availability and the type of respiration. Finally, we identified a panel of bacterial biomarkers that allow the discrimination between eubiosis from dysbiosis with a high diagnostic performance (96% accurately), which could be used for the development of non-invasive diagnostic methods. Thus, this study is a step forward towards understanding the landscapes and alterations of mucosaassociated intestinal microbiota in patients with IBDs.Shared Science Publishers Og20242024-09-1820212021-09-0120212021-09-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23342reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/233422026-06-12T12:43:37Z
dc.title.none.fl_str_mv Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
title Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
spellingShingle Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
Chamorro, Nayaret
Mucosa-associated intestinal microbiota
Inflammatory bowel disease
Ulcerative Colitis
Crohn's Disease
Microbiome
Bacterial biomarkers
Dysbiosis
title_short Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
title_full Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
title_fullStr Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
title_full_unstemmed Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
title_sort Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
dc.creator.none.fl_str_mv Chamorro, Nayaret
Montero, David A
Gallardo, Pablo
Farfan, Mauricio
Contreras, Mauricio
De la Fuente, Marjorie
Dubois, Karen
Hermoso, Marcela
Quera, Rodrigo
Pizarro-Guajardo, Marjorie
Paredes-Sabja, Daniel
Ginard Vicens, Daniel
Rossello-Mora, Ramon
Vidal, Roberto
author Chamorro, Nayaret
author_facet Chamorro, Nayaret
Montero, David A
Gallardo, Pablo
Farfan, Mauricio
Contreras, Mauricio
De la Fuente, Marjorie
Dubois, Karen
Hermoso, Marcela
Quera, Rodrigo
Pizarro-Guajardo, Marjorie
Paredes-Sabja, Daniel
Ginard Vicens, Daniel
Rossello-Mora, Ramon
Vidal, Roberto
author_role author
author2 Montero, David A
Gallardo, Pablo
Farfan, Mauricio
Contreras, Mauricio
De la Fuente, Marjorie
Dubois, Karen
Hermoso, Marcela
Quera, Rodrigo
Pizarro-Guajardo, Marjorie
Paredes-Sabja, Daniel
Ginard Vicens, Daniel
Rossello-Mora, Ramon
Vidal, Roberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Mucosa-associated intestinal microbiota
Inflammatory bowel disease
Ulcerative Colitis
Crohn's Disease
Microbiome
Bacterial biomarkers
Dysbiosis
topic Mucosa-associated intestinal microbiota
Inflammatory bowel disease
Ulcerative Colitis
Crohn's Disease
Microbiome
Bacterial biomarkers
Dysbiosis
description Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), cause chronic inflammation of the gut, affecting millions of people worldwide. IBDs have been frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is generally characterized by an increase in abundance of Proteobacteria such as Escherichia coli, and a decrease in abundance of Firmicutes such as Faecalibacterium prausnitzii (an indicator of a healthy colonic microbiota). The mechanisms behind the development of IBDs and dysbiosis are incompletely understood. Using samples from colonic biopsies, we studied the mucosa-associated intestinal microbiota in Chilean and Spanish patients with IBD. In agreement with previous studies, microbiome comparison between IBD patients and non-IBD controls indicated that dysbiosis in these patients is characterized by an increase of pro-inflammatory bacteria (mostly Proteobacteria) and a decrease of commensal beneficial bacteria (mostly Firmicutes). Notably, bacteria typically residing on the mucosa of healthy individuals were mostly obligate anaerobes, whereas in the inflamed mucosa an increase of facultative anaerobe and aerobic bacteria was observed. We also identify potential co-occurring and mutually exclusive interactions between bacteria associated with the healthy and inflamed mucosa, which appear to be determined by the oxygen availability and the type of respiration. Finally, we identified a panel of bacterial biomarkers that allow the discrimination between eubiosis from dysbiosis with a high diagnostic performance (96% accurately), which could be used for the development of non-invasive diagnostic methods. Thus, this study is a step forward towards understanding the landscapes and alterations of mucosaassociated intestinal microbiota in patients with IBDs.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-01
2021
2021-09-01
2024
2024-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23342
url https://hdl.handle.net/20.500.12105/23342
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Shared Science Publishers Og
publisher.none.fl_str_mv Shared Science Publishers Og
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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