West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)

Busquets, Núria|||0000-0001-5246-8260; Gardela Santacruz, Jaume|||0000-0001-7524-2088; José Cunilleras, Eduard|||0000-0002-4536-7717; Solé, Alba; Salvador, Maria José; Obón, Elena|||0000-0003-4228-717X; Molina López, Rafael|||0000-0002-9043-2346; Aranda Pallero, Carles|||0000-0003-1496-8306; Montalvo Porro, Tomas|||0000-0002-9060-3205; Corbella, Irene; Bou-Monclús, Maria Assumpció|||0009-0000-8202-437X; Martíne, Miguel Julián; Vázquez González, Ana|||0000-0002-9872-3316; Piron, Maria|||0000-0001-6858-9374; Sauleda, Sílvia; Pailler-García, Lola|||0000-0003-1211-7057; Napp Avelli, Sebastián|||0000-0001-5813-7286

West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)

West Nile virus (WNV), mainly transmitted by Culex mosquitoes, poses significant health risks to humans and horses, particularly in endemic regions. The first detection of WNV lineage 2 in Spain was in 2017 in Catalonia (northeastern Spain). In 2023, WNV was confirmed in a young yellow-legged gull a...

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Autores:	Busquets, Núria\|\|\|0000-0001-5246-8260, Gardela Santacruz, Jaume\|\|\|0000-0001-7524-2088, José Cunilleras, Eduard\|\|\|0000-0002-4536-7717, Solé, Alba, Salvador, Maria José, Obón, Elena\|\|\|0000-0003-4228-717X, Molina López, Rafael\|\|\|0000-0002-9043-2346, Aranda Pallero, Carles\|\|\|0000-0003-1496-8306, Montalvo Porro, Tomas\|\|\|0000-0002-9060-3205, Corbella, Irene, Bou-Monclús, Maria Assumpció\|\|\|0009-0000-8202-437X, Martíne, Miguel Julián, Vázquez González, Ana\|\|\|0000-0002-9872-3316, Piron, Maria\|\|\|0000-0001-6858-9374, Sauleda, Sílvia, Pailler-García, Lola\|\|\|0000-0003-1211-7057, Napp Avelli, Sebastián\|\|\|0000-0001-5813-7286
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:319642
Acceso en línea:	https://ddd.uab.cat/record/319642 https://dx.doi.org/urn:doi:10.1016/j.onehlt.2025.101150
Access Level:	acceso abierto
Palabra clave:	Arbovirus Zoonosis Vector-borne diseases Public health surveillance Mosquito vectors Human health Animal health Flavivirus

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spelling	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)A One-Health surveillance approachBusquets, Núria\|\|\|0000-0001-5246-8260Gardela Santacruz, Jaume\|\|\|0000-0001-7524-2088José Cunilleras, Eduard\|\|\|0000-0002-4536-7717Solé, AlbaSalvador, Maria JoséObón, Elena\|\|\|0000-0003-4228-717XMolina López, Rafael\|\|\|0000-0002-9043-2346Aranda Pallero, Carles\|\|\|0000-0003-1496-8306Montalvo Porro, Tomas\|\|\|0000-0002-9060-3205Corbella, IreneBou-Monclús, Maria Assumpció\|\|\|0009-0000-8202-437XMartíne, Miguel JuliánVázquez González, Ana\|\|\|0000-0002-9872-3316Piron, Maria\|\|\|0000-0001-6858-9374Sauleda, SílviaPailler-García, Lola\|\|\|0000-0003-1211-7057Napp Avelli, Sebastián\|\|\|0000-0001-5813-7286ArbovirusZoonosisVector-borne diseasesPublic health surveillanceMosquito vectorsHuman healthAnimal healthFlavivirusWest Nile virus (WNV), mainly transmitted by Culex mosquitoes, poses significant health risks to humans and horses, particularly in endemic regions. The first detection of WNV lineage 2 in Spain was in 2017 in Catalonia (northeastern Spain). In 2023, WNV was confirmed in a young yellow-legged gull and a probable human case was notified within the urban settings. We aimed to define the zone of WNV circulation in the Barcelona Metropolitan Area where these infections occurred and the effectiveness of the One Health approach for early WNV detection. The Catalan WNV surveillance and control programs includes the testing of horses, birds, mosquitoes and humans following molecular and serological methods. Phylogenetic analyses were performed to determine the origin of the circulating virus. IgM-positive data from both active and passive surveillance in horses identified the area of WNV circulation and suggested that WNV circulation happened either before or concurrently with human and bird infections in the agricultural and peri-urban areas. Furthermore, a new WNV introduction was discarded by phylogenetic studies, demonstrating that WNV lineage 2 has been established in Catalonia, albeit at a low level of circulation since the virus was not detected in blood donors. Our findings underscore the importance of integrating active and passive surveillance strategies to early assess WNV circulation and activate public health responses. The study highlights the role of wildlife in the WNV transmission and emphasizes the need for ongoing monitoring in animals and also mosquito control measures to mitigate the risk of animal and human infections. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/319642https://dx.doi.org/urn:doi:10.1016/j.onehlt.2025.101150reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3196422026-06-06T12:50:31Z
dc.title.none.fl_str_mv	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain) A One-Health surveillance approach
title	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
spellingShingle	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain) Busquets, Núria\|\|\|0000-0001-5246-8260 Arbovirus Zoonosis Vector-borne diseases Public health surveillance Mosquito vectors Human health Animal health Flavivirus
title_short	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
title_full	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
title_fullStr	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
title_full_unstemmed	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
title_sort	West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)
dc.creator.none.fl_str_mv	Busquets, Núria\|\|\|0000-0001-5246-8260 Gardela Santacruz, Jaume\|\|\|0000-0001-7524-2088 José Cunilleras, Eduard\|\|\|0000-0002-4536-7717 Solé, Alba Salvador, Maria José Obón, Elena\|\|\|0000-0003-4228-717X Molina López, Rafael\|\|\|0000-0002-9043-2346 Aranda Pallero, Carles\|\|\|0000-0003-1496-8306 Montalvo Porro, Tomas\|\|\|0000-0002-9060-3205 Corbella, Irene Bou-Monclús, Maria Assumpció\|\|\|0009-0000-8202-437X Martíne, Miguel Julián Vázquez González, Ana\|\|\|0000-0002-9872-3316 Piron, Maria\|\|\|0000-0001-6858-9374 Sauleda, Sílvia Pailler-García, Lola\|\|\|0000-0003-1211-7057 Napp Avelli, Sebastián\|\|\|0000-0001-5813-7286
author	Busquets, Núria\|\|\|0000-0001-5246-8260
author_facet	Busquets, Núria\|\|\|0000-0001-5246-8260 Gardela Santacruz, Jaume\|\|\|0000-0001-7524-2088 José Cunilleras, Eduard\|\|\|0000-0002-4536-7717 Solé, Alba Salvador, Maria José Obón, Elena\|\|\|0000-0003-4228-717X Molina López, Rafael\|\|\|0000-0002-9043-2346 Aranda Pallero, Carles\|\|\|0000-0003-1496-8306 Montalvo Porro, Tomas\|\|\|0000-0002-9060-3205 Corbella, Irene Bou-Monclús, Maria Assumpció\|\|\|0009-0000-8202-437X Martíne, Miguel Julián Vázquez González, Ana\|\|\|0000-0002-9872-3316 Piron, Maria\|\|\|0000-0001-6858-9374 Sauleda, Sílvia Pailler-García, Lola\|\|\|0000-0003-1211-7057 Napp Avelli, Sebastián\|\|\|0000-0001-5813-7286
author_role	author
author2	Gardela Santacruz, Jaume\|\|\|0000-0001-7524-2088 José Cunilleras, Eduard\|\|\|0000-0002-4536-7717 Solé, Alba Salvador, Maria José Obón, Elena\|\|\|0000-0003-4228-717X Molina López, Rafael\|\|\|0000-0002-9043-2346 Aranda Pallero, Carles\|\|\|0000-0003-1496-8306 Montalvo Porro, Tomas\|\|\|0000-0002-9060-3205 Corbella, Irene Bou-Monclús, Maria Assumpció\|\|\|0009-0000-8202-437X Martíne, Miguel Julián Vázquez González, Ana\|\|\|0000-0002-9872-3316 Piron, Maria\|\|\|0000-0001-6858-9374 Sauleda, Sílvia Pailler-García, Lola\|\|\|0000-0003-1211-7057 Napp Avelli, Sebastián\|\|\|0000-0001-5813-7286
author2_role	author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Arbovirus Zoonosis Vector-borne diseases Public health surveillance Mosquito vectors Human health Animal health Flavivirus
topic	Arbovirus Zoonosis Vector-borne diseases Public health surveillance Mosquito vectors Human health Animal health Flavivirus
description	West Nile virus (WNV), mainly transmitted by Culex mosquitoes, poses significant health risks to humans and horses, particularly in endemic regions. The first detection of WNV lineage 2 in Spain was in 2017 in Catalonia (northeastern Spain). In 2023, WNV was confirmed in a young yellow-legged gull and a probable human case was notified within the urban settings. We aimed to define the zone of WNV circulation in the Barcelona Metropolitan Area where these infections occurred and the effectiveness of the One Health approach for early WNV detection. The Catalan WNV surveillance and control programs includes the testing of horses, birds, mosquitoes and humans following molecular and serological methods. Phylogenetic analyses were performed to determine the origin of the circulating virus. IgM-positive data from both active and passive surveillance in horses identified the area of WNV circulation and suggested that WNV circulation happened either before or concurrently with human and bird infections in the agricultural and peri-urban areas. Furthermore, a new WNV introduction was discarded by phylogenetic studies, demonstrating that WNV lineage 2 has been established in Catalonia, albeit at a low level of circulation since the virus was not detected in blood donors. Our findings underscore the importance of integrating active and passive surveillance strategies to early assess WNV circulation and activate public health responses. The study highlights the role of wildlife in the WNV transmission and emphasizes the need for ongoing monitoring in animals and also mosquito control measures to mitigate the risk of animal and human infections.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/319642 https://dx.doi.org/urn:doi:10.1016/j.onehlt.2025.101150
url	https://ddd.uab.cat/record/319642 https://dx.doi.org/urn:doi:10.1016/j.onehlt.2025.101150
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
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dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
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West Nile virus transmission in the Metropolitan Area of Barcelona (Spain)

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