Adherence to the Mediterranean diet and frailty criteria in an old population with metabolic syndrome: a cross-sectional analysis

Objectives: Frailty has emerged as a key indicator of biological aging. This study aimed to assess the relationship between MedDiet adherence and frailty prevalence in the context of metabolic syndrome (MetS). Design: Cross-sectional study. Baseline data from PREDIMED-Plus trial Setting: Primary car...

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Detalles Bibliográficos
Autores: Torrego Ellacuría, Macarena, Cuesta Triana, Federico, Ortiz Ramos, María, Martínez González, Miguel Ángel, Corella, Dolores, Vázquez-Lorente, Héctor, Fitó, Montserrat, Martínez, José Alfredo, Tojal-Sierra, Lucas, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, F. J., Santos-Lozano, J. M., Serra-Majem, Lluis, Bueno-Cavanillas, A., Tur, Josep A., Romero Vigara, Juan Carlos, Pintó, Xavier, Gaforio, José J., Vidal, Josep, Mas-Fontao, Sebastián, Daimiel, Lidia, Chiva-Blanch, Gema, Basterra Gortari, Francisco Javier, Gutierrez, Liliana, Sorli, Jose V., Minguella Muñoz, Elisa, García-Ríos, Antonio, Bernabé Casanova, Andrea, Gómez-Gracia, Enrique, Zulet, Maria Angeles, Nafría, Mar, Casas, Rosa, Garrido-Garrido, Eva M., Goicolea-Güemez, Leire, Gómez Pérez, Ana María, Ruiz Canela, Miguel, Megias, Isabel, Valero Barceló, Carmen, Montenegro Calvo, Marina, Peña-Orihuela, Patricia J., Tercero Marciá, Cristina, Razquin, Cristina, Babio, Nancy, Sala de Vedruna, Adriana, Barabash Bustelo, Ana, Matía-Martín, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:dnet:academicae__::67d291e48ce3505888bb4ae79942ffcc
Acceso en línea:https://hdl.handle.net/2454/56721
Access Level:acceso abierto
Palabra clave:Frailty
Mediterranean diet
Metabolic syndrome
Obesity
Overweight
Prefrailty
Descripción
Sumario:Objectives: Frailty has emerged as a key indicator of biological aging. This study aimed to assess the relationship between MedDiet adherence and frailty prevalence in the context of metabolic syndrome (MetS). Design: Cross-sectional study. Baseline data from PREDIMED-Plus trial Setting: Primary care health, 23 recruitment sites (2013–2016). Participants: A total of 6874 participants with overweight/obesity and ≥3 MetS components. Measurements: Adherence to the MedDiet: 17-item MedDiet score. Frailty and prefrailty (3 or 1–2 criteria): modified Fried Frailty Index (FFI), considering exhaustion, physical activity and functional capacity. Main independent variable was analysed: as a continuous variable (range: 0–17); in quartiles of adherence using univariate and multivariate logistic regression models adjusted for potential confounders. Results: Prefrailty and frailty prevalence were 49.7% and 2.9%, respectively. Compared to those with the lowest MedDiet adherence (0–6), participants with the highest adherence (11–17) had significantly lower odds of meeting frailty criteria. Fully adjusted models showed ORs of 0.479 (p = 0.097) for frailty, 0.705 (p = 0.001) for prefrailty, and 0.694 (p = 0.001) for frailty or prefrailty in participants with higher/greater MedDiet adherence. Each 1-point increase in the 17-item score was associated with an OR ranging from 0.878 to 0.977 (p < 0.05 for all comparisons, except functional capacity: p = 0.100). When adherence was dichotomized, the adjusted ORs ranged from 0.406 to 0.834 (p < 0.05 for all comparisons). Conclusions: Higher adherence to MedDiet was associated with a lower prevalence of frailty and prefrailty in older adults with overweight/obesity and MetS, reinforcing its potential role in promoting healthy aging despite cardiometabolic comorbidities.

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