Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives

© 2020 by the authors.

Detalhes bibliográficos
Autores: Piehler, Susann, Dähring, Heidi, Grandke, Julia, Göring, Julia, Couleaud, Pierre, Aires, Antonio, Cortajarena, Aitziber L., Courty, José, Latorre, Alfonso, Somoza, Álvaro, Teichgräber, Ulf, Hilger, Ingrid
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/229309
Acesso em linha:http://hdl.handle.net/10261/229309
Access Level:acceso abierto
Palavra-chave:Magnetic hyperthermia
Magnetic nanoparticles
Doxorubicin
Breast cancer
Mouse model
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spelling Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectivesPiehler, SusannDähring, HeidiGrandke, JuliaGöring, JuliaCouleaud, PierreAires, AntonioCortajarena, Aitziber L.Courty, JoséLatorre, AlfonsoSomoza, ÁlvaroTeichgräber, UlfHilger, IngridMagnetic hyperthermiaMagnetic nanoparticlesDoxorubicinBreast cancerMouse model© 2020 by the authors.There is still a need for improving the treatment of breast cancer with doxorubicin (DOX). In this paper, we functionalized magnetic nanoparticles (MNPs) with DOX and studied the DOX-induced antitumor effects in breast cancer cells (BT474) in the presence of magnetic hyperthermia (43 °C, 1 h). We show that i) intratumoral application of DOX-functionalized MNPs (at least at a concentration of 9.6 nmol DOX/100 mm3 tumor volume) combined with magnetic hyperthermia favors tumor regression in vivo, and there is evidence for an increased effect compared to magnetic hyperthermia alone or to the intratumoral application of free DOX and ii) the presence of the pseudopeptide NucAnt (N6L) on the MNP surface might well be beneficial in its function as carrier for MNP internalization into breast cancer cells in vitro, which could further augment the possibility of the induction of intracellular heating spots and cell death in the future.The described work was carried out within the project “Multifunctional Nanoparticles for the Selective Detection and Treatment of Cancer” (Multifun), funded by the European Commission (Nr. 262943) and in parts by the European Union’s Horizon 2020 research and innovation program under grant agreement No 685795 and the Spanish Ministry of Economy and Competitiveness (SAF2017-87305-R). IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686).Multidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/229309reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/262943info:eu-repo/grantAgreement/EC/H2020/685795info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-87305-RSAF2017-87305-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2016-0686http://dx.doi.org/10.3390/nano10061016Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2293092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
title Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
spellingShingle Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
Piehler, Susann
Magnetic hyperthermia
Magnetic nanoparticles
Doxorubicin
Breast cancer
Mouse model
title_short Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
title_full Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
title_fullStr Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
title_full_unstemmed Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
title_sort Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives
dc.creator.none.fl_str_mv Piehler, Susann
Dähring, Heidi
Grandke, Julia
Göring, Julia
Couleaud, Pierre
Aires, Antonio
Cortajarena, Aitziber L.
Courty, José
Latorre, Alfonso
Somoza, Álvaro
Teichgräber, Ulf
Hilger, Ingrid
author Piehler, Susann
author_facet Piehler, Susann
Dähring, Heidi
Grandke, Julia
Göring, Julia
Couleaud, Pierre
Aires, Antonio
Cortajarena, Aitziber L.
Courty, José
Latorre, Alfonso
Somoza, Álvaro
Teichgräber, Ulf
Hilger, Ingrid
author_role author
author2 Dähring, Heidi
Grandke, Julia
Göring, Julia
Couleaud, Pierre
Aires, Antonio
Cortajarena, Aitziber L.
Courty, José
Latorre, Alfonso
Somoza, Álvaro
Teichgräber, Ulf
Hilger, Ingrid
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Magnetic hyperthermia
Magnetic nanoparticles
Doxorubicin
Breast cancer
Mouse model
topic Magnetic hyperthermia
Magnetic nanoparticles
Doxorubicin
Breast cancer
Mouse model
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/229309
url http://hdl.handle.net/10261/229309
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/262943
info:eu-repo/grantAgreement/EC/H2020/685795
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-87305-R
SAF2017-87305-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2016-0686
http://dx.doi.org/10.3390/nano10061016
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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