Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation...

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Detalles Bibliográficos
Autores: García Hevia, Lorena|||0000-0001-8275-7733, Valiente Barroso, Rafael|||0000-0001-9855-8309, Fernández Luna, José Luis, Flahaut, Emanuel, Rodríguez Fernández, Lidia, Villegas Sordo, Juan Carlos|||0000-0003-3293-8653, González Gómez, Jesús Antonio|||0000-0002-0381-6393, López Fanarraga, Mónica|||0000-0003-4754-311X
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/7930
Acceso en línea:http://hdl.handle.net/10902/7930
Access Level:acceso abierto
Palabra clave:Biomechanics
Cancer
Cytoskeleton
Metastasis
Tubulin polymers
Descripción
Sumario:Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.

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