Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults

The APOE ε4 allele (APOE4) is a known risk factor for neurodegenerative and cardiovascular diseases, but its link to body composition and metabolism remains debated. The gut microbiota influences host metabolism and immunity, yet its relationship with APOE genotype in healthy individuals is not well...

Descripción completa

Detalles Bibliográficos
Autores: Bressa, Carlo, González Soltero, María del Rocío, Tabone, Mariangela, Clemente Velasco, Sara, Gálvez, Beatriz, Larrosa Pérez, Mar
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/14633
Acceso en línea:http://hdl.handle.net/11268/14633
Access Level:acceso abierto
Palabra clave:Microbiota
Enfermedad de alzheimer
Genética
Goal 3: Ensure healthy lives and promote well-being for all at all ages
id ES_703dfd3748214988914280a4589500d9
oai_identifier_str oai:abacus.universidadeuropea.com:11268/14633
network_acronym_str ES
network_name_str España
repository_id_str
spelling Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adultsBressa, CarloGonzález Soltero, María del RocíoTabone, MariangelaClemente Velasco, SaraGálvez, BeatrizLarrosa Pérez, MarMicrobiotaEnfermedad de alzheimerGenéticaGoal 3: Ensure healthy lives and promote well-being for all at all agesThe APOE ε4 allele (APOE4) is a known risk factor for neurodegenerative and cardiovascular diseases, but its link to body composition and metabolism remains debated. The gut microbiota influences host metabolism and immunity, yet its relationship with APOE genotype in healthy individuals is not well understood. The objective of this work was to examine associations between APOE genotype and gut microbiota composition and function in healthy adults, focusing on microbial and metabolic differences related to the APOE4 allele. Seventy-seven healthy Spanish adults were genotyped for APOE. Fecal microbiota profiles were assessed by 16 S rRNA gene sequencing, and predicted functions were inferred using PICRUSt2. Body composition (DEXA) and physical activity (accelerometry) were also measured. APOE4 carriers exhibited subtle shifts in microbiota composition, including a five-fold reduction in Megamonas and lower abundance of the Eubacterium brachy group—both linked to energy harvest and adiposity—compared to APOE3 homozygotes. An uncharacterized Puniceicoccaceae genus was enriched in APOE4 carriers. Although E. brachy group abundance correlated with adiposity, no significant differences in body composition were observed. Functional predictions showed APOE4-associated microbiota enriched in pathways for carotenoid biosynthesis and trehalose metabolism, and depleted in tryptophan biosynthesis, propionate production, and multidrug resistance mechanisms. APOE4 carriers harbor gut microbiota with distinct taxonomic and functional features, potentially reflecting adaptations to metabolic and oxidative challenges. These findings underscore the relevance of the gut microbiome in shaping APOE4-associated phenotypes and warrant further investigation into its mechanistic contributions to health and disease.20252025-05-2420252025-05-1520252025-05-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/14633reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/146332026-06-11T12:41:27Z
dc.title.none.fl_str_mv Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
title Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
spellingShingle Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
Bressa, Carlo
Microbiota
Enfermedad de alzheimer
Genética
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
title_full Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
title_fullStr Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
title_full_unstemmed Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
title_sort Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adults
dc.creator.none.fl_str_mv Bressa, Carlo
González Soltero, María del Rocío
Tabone, Mariangela
Clemente Velasco, Sara
Gálvez, Beatriz
Larrosa Pérez, Mar
author Bressa, Carlo
author_facet Bressa, Carlo
González Soltero, María del Rocío
Tabone, Mariangela
Clemente Velasco, Sara
Gálvez, Beatriz
Larrosa Pérez, Mar
author_role author
author2 González Soltero, María del Rocío
Tabone, Mariangela
Clemente Velasco, Sara
Gálvez, Beatriz
Larrosa Pérez, Mar
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Microbiota
Enfermedad de alzheimer
Genética
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Microbiota
Enfermedad de alzheimer
Genética
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description The APOE ε4 allele (APOE4) is a known risk factor for neurodegenerative and cardiovascular diseases, but its link to body composition and metabolism remains debated. The gut microbiota influences host metabolism and immunity, yet its relationship with APOE genotype in healthy individuals is not well understood. The objective of this work was to examine associations between APOE genotype and gut microbiota composition and function in healthy adults, focusing on microbial and metabolic differences related to the APOE4 allele. Seventy-seven healthy Spanish adults were genotyped for APOE. Fecal microbiota profiles were assessed by 16 S rRNA gene sequencing, and predicted functions were inferred using PICRUSt2. Body composition (DEXA) and physical activity (accelerometry) were also measured. APOE4 carriers exhibited subtle shifts in microbiota composition, including a five-fold reduction in Megamonas and lower abundance of the Eubacterium brachy group—both linked to energy harvest and adiposity—compared to APOE3 homozygotes. An uncharacterized Puniceicoccaceae genus was enriched in APOE4 carriers. Although E. brachy group abundance correlated with adiposity, no significant differences in body composition were observed. Functional predictions showed APOE4-associated microbiota enriched in pathways for carotenoid biosynthesis and trehalose metabolism, and depleted in tryptophan biosynthesis, propionate production, and multidrug resistance mechanisms. APOE4 carriers harbor gut microbiota with distinct taxonomic and functional features, potentially reflecting adaptations to metabolic and oxidative challenges. These findings underscore the relevance of the gut microbiome in shaping APOE4-associated phenotypes and warrant further investigation into its mechanistic contributions to health and disease.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-05-24
2025
2025-05-15
2025
2025-05-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/14633
url http://hdl.handle.net/11268/14633
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410566496321536
score 15,812429

Similares en LA Referencia