| Resumo: | Entzumen-galera (hipoakusia) eta narriadura kognitiboa zahartzaroarekin lotuta dauden bi egoera dira. Bi faktoreek bata bestean eragina dute. Entzumen-seinalearen transmisioan tentsio-menpeko potasio-kanalak funtsezkoak dira. Hortaz, kanal horietako aldaketek soinuaren bereizketa zuzenari eragin diezaiokete, eta entzumen-galera bultzatu. Gainera, garuneko potasio-kanalen disfuntzioek neuroendekapenezko prozesuak eragin ditzakete. Hainbat ikerketak agerian utzi dute alterazioak daudela Alzheimerra duten pazienteen tentsio-menpeko potasio-kanalen adierazpenean eta funtzioan. Uste da alterazioek zenbait mekanismo patologiko agertzea eragin dezaketela, horien artean, neuronen kitzikakortasunaren aldaketa, neuroinflamazioa eta neuronen apoptosia. Hori dela eta, entzunbideko tentsio-menpeko potasio-kanalak itu terapeutiko moduan erabiltzeak eta haien funtzioa modulatzeak Alzheimerraren garapena moteltzeko bidea irekiko luke, eta, aldi berean, pazienteen bizi-kalitatea hobetzeko aukera emango luke.; Hearing loss or hypoacusia and cognitive impairment are two situations associated with aging. Two factors are correlated. In the hearing signal transmission voltage-gated potassium channels are essential. The possible changes in these channels can therefore affect the correct separation of sound and cause hearingloss. In addition, dysfunctions in brain potassium channels can cause neurodegenerative processes. Experts have investigated alterations in the expression and function of voltage-gated potassium channels in Alzheimer's patients. These alterations are supposed to cause the appearance of certain pathological mechanisms, including the alteration of the excitability of neurons, neuroinflammation, and neuronal apoptosis. Therefore, the use of voltage-gated potassium channels of the auditory pathway as therapeutic targets and its modulation would help to slow down the development of Alzheimer's disease and, at the same time, it would improve the live quality of patients.
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