Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2

The current global pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has demonstrated the necessity to develop novel materials with antimicrobial and antiviral activities to prevent the infection. One significant route for the spread of diseases is by the transmi...

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Detalles Bibliográficos
Autores: Losada-García, Noelia, Vázquez-Calvo, Ángela, Alcamí, Antonio, Palomo, José Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/348437
Acceso en línea:http://hdl.handle.net/10261/348437
https://api.elsevier.com/content/abstract/scopus_id/85156215626
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Antiviral material
Copper
Surface coating
Viruses
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spelling Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2Losada-García, NoeliaVázquez-Calvo, ÁngelaAlcamí, AntonioPalomo, José MiguelSARS-CoV-2Antiviral materialCopperSurface coatingVirusesThe current global pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has demonstrated the necessity to develop novel materials with antimicrobial and antiviral activities to prevent the infection. One significant route for the spread of diseases is by the transmission of the virus through contact with contaminated surfaces. Antiviral surface treatments can help to reduce or even avoid these hazards. In particular, the development of active-virucidal fabrics or paints represents a very important challenge with multiple applications in hospitals, public transports, or schools. Modern, cutting-edge methods for creating antiviral surface coatings use either materials with a metal base or sophisticated synthetic polymers. Even if these methods are effective, they will still face significant obstacles in terms of large-scale applicability. Here, we describe the preparation of fabrics and paints treated with a scaled-up novel nanostructured biohybrid material composed of very small crystalline phosphate copper(II) nanoparticles, synthesized based on a technology that employs the use of a small amount of biological agent for its formation at room temperature in aqueous media. We demonstrate the efficient inactivation of the human coronavirus 229E (HCoV-229E), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, and non-enveloped human rhinovirus 14 (HRV-14) (>99.9%) using an inexpensive, ecologically friendly coating agent. The reactive oxygen species produced during the oxidation of water or the more intensive reaction with hydrogen peroxide are believed to be the cause of the antiviral mechanism of the nanostructured material. In contrast to the release of a specific antiviral drug, this process does not consume the surface coating and does not need regeneration. A 12-month aging research that revealed no decline in antiviral activity is proof that the coating is durable in ambient circumstances. Also, the coated fabric can be reused after different washing cycles, even at moderate to high temperatures.This work was supported by the Spanish National Research Council (CSIC) (projects Intramural Grant 202020E254, CSIC PTI-Global Health SGL2103036 (J.M.P.), and European Union (Next-generation EU)). The authors thank Dr. Martinez from Novozymes for the gift of CALB enzyme.Peer reviewedAmerican Chemical SocietyConsejo Superior de Investigaciones Científicas (España)European CommissionPalomo, José M. [0000-0002-6464-1216]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/348437https://api.elsevier.com/content/abstract/scopus_id/85156215626reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1021/acsami.3c03357Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3484372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
title Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
spellingShingle Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
Losada-García, Noelia
SARS-CoV-2
Antiviral material
Copper
Surface coating
Viruses
title_short Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
title_full Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
title_fullStr Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
title_full_unstemmed Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
title_sort Preparation of Highly Stable and Cost-Efficient Antiviral Materials for Reducing Infections and Avoiding the Transmission of Viruses such as SARS-CoV-2
dc.creator.none.fl_str_mv Losada-García, Noelia
Vázquez-Calvo, Ángela
Alcamí, Antonio
Palomo, José Miguel
author Losada-García, Noelia
author_facet Losada-García, Noelia
Vázquez-Calvo, Ángela
Alcamí, Antonio
Palomo, José Miguel
author_role author
author2 Vázquez-Calvo, Ángela
Alcamí, Antonio
Palomo, José Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
European Commission
Palomo, José M. [0000-0002-6464-1216]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv SARS-CoV-2
Antiviral material
Copper
Surface coating
Viruses
topic SARS-CoV-2
Antiviral material
Copper
Surface coating
Viruses
description The current global pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has demonstrated the necessity to develop novel materials with antimicrobial and antiviral activities to prevent the infection. One significant route for the spread of diseases is by the transmission of the virus through contact with contaminated surfaces. Antiviral surface treatments can help to reduce or even avoid these hazards. In particular, the development of active-virucidal fabrics or paints represents a very important challenge with multiple applications in hospitals, public transports, or schools. Modern, cutting-edge methods for creating antiviral surface coatings use either materials with a metal base or sophisticated synthetic polymers. Even if these methods are effective, they will still face significant obstacles in terms of large-scale applicability. Here, we describe the preparation of fabrics and paints treated with a scaled-up novel nanostructured biohybrid material composed of very small crystalline phosphate copper(II) nanoparticles, synthesized based on a technology that employs the use of a small amount of biological agent for its formation at room temperature in aqueous media. We demonstrate the efficient inactivation of the human coronavirus 229E (HCoV-229E), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, and non-enveloped human rhinovirus 14 (HRV-14) (>99.9%) using an inexpensive, ecologically friendly coating agent. The reactive oxygen species produced during the oxidation of water or the more intensive reaction with hydrogen peroxide are believed to be the cause of the antiviral mechanism of the nanostructured material. In contrast to the release of a specific antiviral drug, this process does not consume the surface coating and does not need regeneration. A 12-month aging research that revealed no decline in antiviral activity is proof that the coating is durable in ambient circumstances. Also, the coated fabric can be reused after different washing cycles, even at moderate to high temperatures.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/348437
https://api.elsevier.com/content/abstract/scopus_id/85156215626
url http://hdl.handle.net/10261/348437
https://api.elsevier.com/content/abstract/scopus_id/85156215626
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1021/acsami.3c03357
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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