Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis

Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neur...

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Autores: Murillo García, Nancy, Setién Suero, María Esther, Pardo-de-Santayana, Guillermo, Murillo-García, Marisol, Pelayo Terán, José María, Crespo Facorro, Benedicto|||0000-0001-9709-1276, Ayesa Arriola, Rosa
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/37216
Acceso en línea:https://hdl.handle.net/10902/37216
Access Level:acceso abierto
Palabra clave:Cognition
Cognitive impairment
Neuropsychology
Psychosis
Psychotic disorders
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spelling Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosisMurillo García, NancySetién Suero, María EstherPardo-de-Santayana, GuillermoMurillo-García, MarisolPelayo Terán, José MaríaCrespo Facorro, Benedicto|||0000-0001-9709-1276Ayesa Arriola, RosaCognitionCognitive impairmentNeuropsychologyPsychosisPsychotic disordersAim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neurocognitive specific domains, and a global indicator of neurocognitive impairment (global deficits score, GDS) was calculated. According to the DAP quartiles, four subgroups were formed, and these were compared. In addition, a logistic regression analysis was carried out to predict neurocognitive impairment at 3-year follow-up. Results: FEP patients with the longest DAP (more than 18.36 months) presented a more severe global neurocognitive impairment evidenced in their GDS, both at baseline (F = 5.53; p< .01) and at 3-year follow-up (F = 4.16; p< .01). Moreover, a subgroup of participants with DAP between 7.40 and 18.36 months showed a specific attentional decline over the 3-year follow-up (F = 3.089; p< .05).The logistic regression model showed that sex (Wald = 7.29, p<.010), premorbid adjustment (Wald = 7.24, p<.010), attention (Wald = 12.10, p<.001), verbal memory (Wald = 16.29, p<.001) and visual memory (Wald = 9.41, p<.010) were significant predictors of neurocognitive impairment 3 years after the FEP. The variables composing the DAP were not significant predictors in this model. Conclusions: DAP seems to be related to global neurocognitive impairment in FEP patients. These findings contribute in several ways to our understanding of the effects of active psychosis on the brain, and provide the basis for future research.Instituto de Investigación Sanitaria Valdecilla y Universidad de Cantabria, Grant/Award Number: Predoctoral contract BOC49; REF. IDI-13; Nancy Mur; Instituto de Salud Carlos III, Grant/Award Number: Miguel Servet contract CP18/00003; Dr. Rosa Ayesa-ArriolaWileyUniversidad de Cantabria20212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/37216Early Intervention in Psychiatry, 2021, 15(5), 1266-1275reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/372162026-06-02T12:39:31Z
dc.title.none.fl_str_mv Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
title Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
spellingShingle Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
Murillo García, Nancy
Cognition
Cognitive impairment
Neuropsychology
Psychosis
Psychotic disorders
title_short Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
title_full Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
title_fullStr Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
title_full_unstemmed Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
title_sort Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
dc.creator.none.fl_str_mv Murillo García, Nancy
Setién Suero, María Esther
Pardo-de-Santayana, Guillermo
Murillo-García, Marisol
Pelayo Terán, José María
Crespo Facorro, Benedicto|||0000-0001-9709-1276
Ayesa Arriola, Rosa
author Murillo García, Nancy
author_facet Murillo García, Nancy
Setién Suero, María Esther
Pardo-de-Santayana, Guillermo
Murillo-García, Marisol
Pelayo Terán, José María
Crespo Facorro, Benedicto|||0000-0001-9709-1276
Ayesa Arriola, Rosa
author_role author
author2 Setién Suero, María Esther
Pardo-de-Santayana, Guillermo
Murillo-García, Marisol
Pelayo Terán, José María
Crespo Facorro, Benedicto|||0000-0001-9709-1276
Ayesa Arriola, Rosa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Cognition
Cognitive impairment
Neuropsychology
Psychosis
Psychotic disorders
topic Cognition
Cognitive impairment
Neuropsychology
Psychosis
Psychotic disorders
description Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neurocognitive specific domains, and a global indicator of neurocognitive impairment (global deficits score, GDS) was calculated. According to the DAP quartiles, four subgroups were formed, and these were compared. In addition, a logistic regression analysis was carried out to predict neurocognitive impairment at 3-year follow-up. Results: FEP patients with the longest DAP (more than 18.36 months) presented a more severe global neurocognitive impairment evidenced in their GDS, both at baseline (F = 5.53; p< .01) and at 3-year follow-up (F = 4.16; p< .01). Moreover, a subgroup of participants with DAP between 7.40 and 18.36 months showed a specific attentional decline over the 3-year follow-up (F = 3.089; p< .05).The logistic regression model showed that sex (Wald = 7.29, p<.010), premorbid adjustment (Wald = 7.24, p<.010), attention (Wald = 12.10, p<.001), verbal memory (Wald = 16.29, p<.001) and visual memory (Wald = 9.41, p<.010) were significant predictors of neurocognitive impairment 3 years after the FEP. The variables composing the DAP were not significant predictors in this model. Conclusions: DAP seems to be related to global neurocognitive impairment in FEP patients. These findings contribute in several ways to our understanding of the effects of active psychosis on the brain, and provide the basis for future research.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/37216
url https://hdl.handle.net/10902/37216
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Early Intervention in Psychiatry, 2021, 15(5), 1266-1275
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410546704449536
score 15.811543

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