Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia

The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic...

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Autores: Høye, Anne, Koyanagi, Ai, Larsson, Henrik, Lehto, Kelli, Lindgren, Peter, Manchia, Mirko, Nordentoft, Merete, Skonieczna-Żydecka, Karolina, Stubbs, Brendon, Vancampfort, Davy, Bitter, István, Vieta i Pascual, Eduard, 1963-, Gorwood, Philip, De Prisco, Michele, Taipale, Heidi, Boyer, Laurent, Tiihonen, Jari, Højlund, Mikkel, Cortese, Samuele, Correll, Christoph U., Dragioti, Elena, Rietz, Ebba Du, Nielsen, Rene Ernst, Firth, Joseph, Fusar-Poli, Paolo, Solmi, Marco, Croatto, Giovanni, Fabiano, Nicholas, Wong, Stanley, Gupta, Arnav, Fornaro, Michele, Schneider, Lynne Kolton, Rohani-Montez, S. Christy, Fairley, Leanne, Smith, Nathalie, Hartman, Catharina, Holt, Richard I. G.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224153
Acesso em linha:https://hdl.handle.net/2445/224153
Access Level:acceso abierto
Palavra-chave:Ressenyes sistemàtiques (Investigació mèdica)
Antipsicòtics
Mortalitat
Esquizofrènia
Metaanàlisi
Systematic reviews (Medical research)
Antipsychotic drugs
Mortality
Schizophrenia
Meta-analysis
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repository_id_str
spelling Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophreniaHøye, AnneKoyanagi, AiLarsson, HenrikLehto, KelliLindgren, PeterManchia, MirkoNordentoft, MereteSkonieczna-Żydecka, KarolinaStubbs, BrendonVancampfort, DavyBitter, IstvánVieta i Pascual, Eduard, 1963-Gorwood, PhilipDe Prisco, MicheleTaipale, HeidiBoyer, LaurentTiihonen, JariHøjlund, MikkelCortese, SamueleCorrell, Christoph U.Dragioti, ElenaRietz, Ebba DuNielsen, Rene ErnstFirth, JosephFusar-Poli, PaoloSolmi, MarcoCroatto, GiovanniFabiano, NicholasWong, StanleyGupta, ArnavFornaro, MicheleSchneider, Lynne KoltonRohani-Montez, S. ChristyFairley, LeanneSmith, NathalieHartman, CatharinaHolt, Richard I. G.Ressenyes sistemàtiques (Investigació mèdica)AntipsicòticsMortalitatEsquizofrèniaMetaanàlisiSystematic reviews (Medical research)Antipsychotic drugsMortalitySchizophreniaMeta-analysisThe differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic review and random-effects metaanalysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. There were minimal statistically significant differences in sex-dependent mortality risks in people with schizophrenia. However, it revealed areas of targeted intervention efforts.Elsevier B.V.2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion70 p.application/pdfhttps://hdl.handle.net/2445/224153Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.euroneuro.2024.11.001European Neuropsychopharmacology, 2025, vol. 91, p. 56-66https://doi.org/10.1016/j.euroneuro.2024.11.001cc-by-nc-nd (c) Elsevier B.V., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2241532026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
title Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
spellingShingle Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
Høye, Anne
Ressenyes sistemàtiques (Investigació mèdica)
Antipsicòtics
Mortalitat
Esquizofrènia
Metaanàlisi
Systematic reviews (Medical research)
Antipsychotic drugs
Mortality
Schizophrenia
Meta-analysis
title_short Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
title_full Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
title_fullStr Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
title_full_unstemmed Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
title_sort Sex-stratified mortality estimates in people with schizophrenia: A systematic review and meta-analysis of cohort studies of 2,700,825 people with schizophrenia
dc.creator.none.fl_str_mv Høye, Anne
Koyanagi, Ai
Larsson, Henrik
Lehto, Kelli
Lindgren, Peter
Manchia, Mirko
Nordentoft, Merete
Skonieczna-Żydecka, Karolina
Stubbs, Brendon
Vancampfort, Davy
Bitter, István
Vieta i Pascual, Eduard, 1963-
Gorwood, Philip
De Prisco, Michele
Taipale, Heidi
Boyer, Laurent
Tiihonen, Jari
Højlund, Mikkel
Cortese, Samuele
Correll, Christoph U.
Dragioti, Elena
Rietz, Ebba Du
Nielsen, Rene Ernst
Firth, Joseph
Fusar-Poli, Paolo
Solmi, Marco
Croatto, Giovanni
Fabiano, Nicholas
Wong, Stanley
Gupta, Arnav
Fornaro, Michele
Schneider, Lynne Kolton
Rohani-Montez, S. Christy
Fairley, Leanne
Smith, Nathalie
Hartman, Catharina
Holt, Richard I. G.
author Høye, Anne
author_facet Høye, Anne
Koyanagi, Ai
Larsson, Henrik
Lehto, Kelli
Lindgren, Peter
Manchia, Mirko
Nordentoft, Merete
Skonieczna-Żydecka, Karolina
Stubbs, Brendon
Vancampfort, Davy
Bitter, István
Vieta i Pascual, Eduard, 1963-
Gorwood, Philip
De Prisco, Michele
Taipale, Heidi
Boyer, Laurent
Tiihonen, Jari
Højlund, Mikkel
Cortese, Samuele
Correll, Christoph U.
Dragioti, Elena
Rietz, Ebba Du
Nielsen, Rene Ernst
Firth, Joseph
Fusar-Poli, Paolo
Solmi, Marco
Croatto, Giovanni
Fabiano, Nicholas
Wong, Stanley
Gupta, Arnav
Fornaro, Michele
Schneider, Lynne Kolton
Rohani-Montez, S. Christy
Fairley, Leanne
Smith, Nathalie
Hartman, Catharina
Holt, Richard I. G.
author_role author
author2 Koyanagi, Ai
Larsson, Henrik
Lehto, Kelli
Lindgren, Peter
Manchia, Mirko
Nordentoft, Merete
Skonieczna-Żydecka, Karolina
Stubbs, Brendon
Vancampfort, Davy
Bitter, István
Vieta i Pascual, Eduard, 1963-
Gorwood, Philip
De Prisco, Michele
Taipale, Heidi
Boyer, Laurent
Tiihonen, Jari
Højlund, Mikkel
Cortese, Samuele
Correll, Christoph U.
Dragioti, Elena
Rietz, Ebba Du
Nielsen, Rene Ernst
Firth, Joseph
Fusar-Poli, Paolo
Solmi, Marco
Croatto, Giovanni
Fabiano, Nicholas
Wong, Stanley
Gupta, Arnav
Fornaro, Michele
Schneider, Lynne Kolton
Rohani-Montez, S. Christy
Fairley, Leanne
Smith, Nathalie
Hartman, Catharina
Holt, Richard I. G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ressenyes sistemàtiques (Investigació mèdica)
Antipsicòtics
Mortalitat
Esquizofrènia
Metaanàlisi
Systematic reviews (Medical research)
Antipsychotic drugs
Mortality
Schizophrenia
Meta-analysis
topic Ressenyes sistemàtiques (Investigació mèdica)
Antipsicòtics
Mortalitat
Esquizofrènia
Metaanàlisi
Systematic reviews (Medical research)
Antipsychotic drugs
Mortality
Schizophrenia
Meta-analysis
description The differential influence of sex on premature mortality in schizophrenia is unclear. This study assessed the differences in all-cause and specific cause mortality risks in people with schizophrenia compared to several control groups stratified by sex. Weconducted a PRISMA 2020-compliant systematic review and random-effects metaanalysis of cohort studies assessing mortality relative risk (RR) for people with schizophrenia, comparing by sex. We measured publication bias and conducted a quality assessment through the Newcastle-Ottawa scale. We meta analyzed 43 studies reporting on 2,700,825 people with schizophrenia. Both males and females with schizophrenia had increased all-cause mortality vs. comparison groups (males, RR=2.62, 95%CI 2.35-2.92; females, RR=2.56, 95%CI 2.27-2.87), suicide (males, RR=9.02, 95%CI 5.96-13.67; females, RR=12.09, 95%CI 9.00-16.25), and natural cause mortality (males, RR=2.11, 95%CI 1.88-2.38; females, RR=2.14, 95%CI 1.93-2.38). No statistically significant differences in sex-dependent mortality risk emerged. There was an age-group-dependent increased mortality risk in females < 40 years vs. >/=40 years old (RR=4.23/2.17), and significantly higher risk of death due to neurological disorders (dementia) in males vs. females (RR=5.19/2.40). Increased mortality risks were often associated with specific modifiable risk factors. There were minimal statistically significant differences in sex-dependent mortality risks in people with schizophrenia. However, it revealed areas of targeted intervention efforts.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224153
url https://hdl.handle.net/2445/224153
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.euroneuro.2024.11.001
European Neuropsychopharmacology, 2025, vol. 91, p. 56-66
https://doi.org/10.1016/j.euroneuro.2024.11.001
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 70 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410546269290496
score 15.812429

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