Outcomes of COVID-19 among hospitalized patients with non-dialysis CKD

Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previou...

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Detalhes bibliográficos
Autores: Coca, Armando, Burballa Tàrrega, Carla, 1988-, Centellas-Pérez, Francisco Javier, Pérez-Sáez, María José, Bustamante-Munguira, Elena, Ortega, Agustín, Dueñas Gutiérrez, Carlos, Arenas, María Dolores (Arenas Jiménez), Pérez-Martínez, Juan, Ruiz, Guadalupe, Crespo Barrio, Marta, Llamas, Francisco, Bustamante-Munguira, Juan, Pascual Santos, Julio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48012
Acesso em linha:http://hdl.handle.net/10230/48012
http://dx.doi.org/10.3389/fmed.2020.615312
Access Level:acceso abierto
Palavra-chave:COVID−19
Acute kidney damage
Chornic kidney disease
Pneumonia
Renal failure
Descrição
Resumo:Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19. Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria. Results: CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR:7.04, 95% CI:2.87-17.29; AKI/CKD HR:5.25, 95% CI: 2.29-12.02), followed by CKD subjects without AKI (HR:3.39, 95% CI:1.36-8.46). CKD status did not condition ICU admission or length of in-hospital stay. Conclusions: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.

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