Tear and aqueous humour cytokine profile in primary open‐angle glaucoma

Purpose: To evaluate the concentrations of pro‐inflammatory cytokines in tear and aqueous humour of patients with primary open‐angle glaucoma (POAG), relative to healthy controls. Method: Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG patients. Twenty‐seven infla...

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Detalles Bibliográficos
Autores: Burgos Blasco, Bárbara, Vidal Villegas, Beatriz, Sáenz Francés, Federico, Morales Fernández, Laura, Perucho González, Lucía, García Feijoo, Julián, Martínez De La Casa Fernández-Borrella, José María
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/6116
Acceso en línea:https://hdl.handle.net/20.500.14352/6116
Access Level:acceso abierto
Palabra clave:617.7-007.681
612.844.4
612.017
Cytokine
Glaucoma
Inflammation
Primary open-angle glaucoma
Bioquímica (Medicina)
Oftalmología
Anatomía ocular
3201.09 Oftalmología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/6116
network_acronym_str ES
network_name_str España
repository_id_str
spelling Tear and aqueous humour cytokine profile in primary open‐angle glaucomaBurgos Blasco, BárbaraVidal Villegas, BeatrizSáenz Francés, FedericoMorales Fernández, LauraPerucho González, LucíaGarcía Feijoo, JuliánMartínez De La Casa Fernández-Borrella, José María617.7-007.681612.844.4612.017CytokineGlaucomaInflammationPrimary open-angle glaucomaBioquímica (Medicina)OftalmologíaAnatomía ocular3201.09 OftalmologíaPurpose: To evaluate the concentrations of pro‐inflammatory cytokines in tear and aqueous humour of patients with primary open‐angle glaucoma (POAG), relative to healthy controls. Method: Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG patients. Twenty‐seven inflammatory cytokines were analysed: interleukin (IL)‐1β, IL‐1ra, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL9, IL‐10, IL‐12, IL‐13, IL‐15, IL‐17, eotaxin, fibroblast growth factor (FGF) basic, granulocyte colony‐stimulating factor, granulocyte‐monocyte colony‐stimulating factor, interferon (IFN)‐γ, interferon gamma‐induced protein, monocyte chemo‐attractant protein‐1, macrophage inflammatory protein (MIP)‐1α, MIP‐1β, platelet‐derived growth factor, regulated on activation normal T cell expressed and secreted, tumour necrosis factor (TNF)‐α and vascular endothelial growth factor (VEGF). Results: In tear samples of glaucoma patients, an increase in IL‐4, IL‐12, IL‐15, FGF‐basic and VEGF was observed, as well as a decrease in MIP‐1a relative to the control group (p < 0.05). IL‐5, IL‐12, IL‐15, IFN‐γ and MIP‐1a were significantly higher in aqueous humour of glaucoma eyes (p < 0.05). A poor correlation between cytokine levels in tear and aqueous humour was observed. Conclusion: The different profiles of inflammatory marker expression of patients with POAG and healthy controls confirm the inflammatory activity of the pathology, indicating that some of them could be used as potential biomarkers of this disease.John Wiley & Sons Ltd.Universidad Complutense de Madrid20202020-02-1120202020-02-11journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/6116reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/61162026-06-02T12:44:21Z
dc.title.none.fl_str_mv Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
title Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
spellingShingle Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
Burgos Blasco, Bárbara
617.7-007.681
612.844.4
612.017
Cytokine
Glaucoma
Inflammation
Primary open-angle glaucoma
Bioquímica (Medicina)
Oftalmología
Anatomía ocular
3201.09 Oftalmología
title_short Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
title_full Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
title_fullStr Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
title_full_unstemmed Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
title_sort Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
dc.creator.none.fl_str_mv Burgos Blasco, Bárbara
Vidal Villegas, Beatriz
Sáenz Francés, Federico
Morales Fernández, Laura
Perucho González, Lucía
García Feijoo, Julián
Martínez De La Casa Fernández-Borrella, José María
author Burgos Blasco, Bárbara
author_facet Burgos Blasco, Bárbara
Vidal Villegas, Beatriz
Sáenz Francés, Federico
Morales Fernández, Laura
Perucho González, Lucía
García Feijoo, Julián
Martínez De La Casa Fernández-Borrella, José María
author_role author
author2 Vidal Villegas, Beatriz
Sáenz Francés, Federico
Morales Fernández, Laura
Perucho González, Lucía
García Feijoo, Julián
Martínez De La Casa Fernández-Borrella, José María
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617.7-007.681
612.844.4
612.017
Cytokine
Glaucoma
Inflammation
Primary open-angle glaucoma
Bioquímica (Medicina)
Oftalmología
Anatomía ocular
3201.09 Oftalmología
topic 617.7-007.681
612.844.4
612.017
Cytokine
Glaucoma
Inflammation
Primary open-angle glaucoma
Bioquímica (Medicina)
Oftalmología
Anatomía ocular
3201.09 Oftalmología
description Purpose: To evaluate the concentrations of pro‐inflammatory cytokines in tear and aqueous humour of patients with primary open‐angle glaucoma (POAG), relative to healthy controls. Method: Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG patients. Twenty‐seven inflammatory cytokines were analysed: interleukin (IL)‐1β, IL‐1ra, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL9, IL‐10, IL‐12, IL‐13, IL‐15, IL‐17, eotaxin, fibroblast growth factor (FGF) basic, granulocyte colony‐stimulating factor, granulocyte‐monocyte colony‐stimulating factor, interferon (IFN)‐γ, interferon gamma‐induced protein, monocyte chemo‐attractant protein‐1, macrophage inflammatory protein (MIP)‐1α, MIP‐1β, platelet‐derived growth factor, regulated on activation normal T cell expressed and secreted, tumour necrosis factor (TNF)‐α and vascular endothelial growth factor (VEGF). Results: In tear samples of glaucoma patients, an increase in IL‐4, IL‐12, IL‐15, FGF‐basic and VEGF was observed, as well as a decrease in MIP‐1a relative to the control group (p < 0.05). IL‐5, IL‐12, IL‐15, IFN‐γ and MIP‐1a were significantly higher in aqueous humour of glaucoma eyes (p < 0.05). A poor correlation between cytokine levels in tear and aqueous humour was observed. Conclusion: The different profiles of inflammatory marker expression of patients with POAG and healthy controls confirm the inflammatory activity of the pathology, indicating that some of them could be used as potential biomarkers of this disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-11
2020
2020-02-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/6116
url https://hdl.handle.net/20.500.14352/6116
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd.
publisher.none.fl_str_mv John Wiley & Sons Ltd.
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410527300550656
score 15.300719

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