The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement

To compare outcomes of total knee replacement (TKR) and total hip replacement (THR) for individuals with RA and OA. We performed a cohort study using routinely collected data. Oxford Knee Score, Oxford Hip Score, and EuroQol 5-dimension 3-level (EQ-5D-3L) questionnaires were collected before and 6 m...

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Autores: Burn, Edward|||0000-0002-9286-1128, Edwards, Christopher J., Murray, David W., Silman, Alan, Cooper, Cyrus|||0000-0003-3510-0709, Arden, N. K|||0000-0002-3452-3382, Pinedo-Villanueva, Rafael|||0000-0002-4723-5128, Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226288
Acceso en línea:https://ddd.uab.cat/record/226288
https://dx.doi.org/urn:doi:10.1093/rheumatology/key409
Access Level:acceso abierto
Palabra clave:Rheumatoid arthritis
Osteoarthritis
Outcome measures
Quality of life
Surgery
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spelling The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacementevidence from routinely collected dataBurn, Edward|||0000-0002-9286-1128Edwards, Christopher J.Murray, David W.Silman, AlanCooper, Cyrus|||0000-0003-3510-0709Arden, N. K|||0000-0002-3452-3382Pinedo-Villanueva, Rafael|||0000-0002-4723-5128Prieto-Alhambra, Daniel|||0000-0002-3950-6346Rheumatoid arthritisOsteoarthritisOutcome measuresQuality of lifeSurgeryTo compare outcomes of total knee replacement (TKR) and total hip replacement (THR) for individuals with RA and OA. We performed a cohort study using routinely collected data. Oxford Knee Score, Oxford Hip Score, and EuroQol 5-dimension 3-level (EQ-5D-3L) questionnaires were collected before and 6 months after surgery. Multivariable regressions were used to estimate the association between diagnosis and post-operative scores after controlling for pre-operative scores and patient characteristics. Study cohorts included 2070 OA and 142 RA patients for TKR and 2030 OA and 98 RA patients for THR. Following TKR, the median Oxford Knee Score was 37 [interquartile range (IQR) 29-43] for OA and 36 (27-42) for RA while the median EQ-5D-3L was 0.76 (0.69-1.00) and 0.69 (0.52-0.85), respectively. After THR, the Oxford Hip Score was 42 (IQR 36-46) for OA and 39 (30-44) for RA while the EQ-5D-3L was 0.85 (0.69-1.00) and 0.69 (0.52-1.00), respectively. The estimated effect of RA, relative to OA, on post-operative scores was -0.05 (95% CI -1.57, 1.48) for the Oxford Knee Score, -0.09 (-0.13, -0.06) for the EQ-5D-3L following TKR, -1.35 (-2.93, -0.22) for the Oxford Hip Score, and -0.08 (-0.12, -0.03) for the EQ-5D-3L following THR. TKR and THR led to substantial improvements in joint-specific scores and overall quality of life. While diagnosis had no clinically meaningful effect on joint-specific outcomes, improvements in general quality of life were somewhat less for those with RA, which is likely due to the systemic and multijoint nature of rheumatoid disease. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226288https://dx.doi.org/urn:doi:10.1093/rheumatology/key409reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2262882026-06-06T12:50:31Z
dc.title.none.fl_str_mv The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
evidence from routinely collected data
title The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
spellingShingle The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
Burn, Edward|||0000-0002-9286-1128
Rheumatoid arthritis
Osteoarthritis
Outcome measures
Quality of life
Surgery
title_short The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
title_full The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
title_fullStr The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
title_full_unstemmed The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
title_sort The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement
dc.creator.none.fl_str_mv Burn, Edward|||0000-0002-9286-1128
Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K|||0000-0002-3452-3382
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
author Burn, Edward|||0000-0002-9286-1128
author_facet Burn, Edward|||0000-0002-9286-1128
Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K|||0000-0002-3452-3382
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
author_role author
author2 Edwards, Christopher J.
Murray, David W.
Silman, Alan
Cooper, Cyrus|||0000-0003-3510-0709
Arden, N. K|||0000-0002-3452-3382
Pinedo-Villanueva, Rafael|||0000-0002-4723-5128
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Rheumatoid arthritis
Osteoarthritis
Outcome measures
Quality of life
Surgery
topic Rheumatoid arthritis
Osteoarthritis
Outcome measures
Quality of life
Surgery
description To compare outcomes of total knee replacement (TKR) and total hip replacement (THR) for individuals with RA and OA. We performed a cohort study using routinely collected data. Oxford Knee Score, Oxford Hip Score, and EuroQol 5-dimension 3-level (EQ-5D-3L) questionnaires were collected before and 6 months after surgery. Multivariable regressions were used to estimate the association between diagnosis and post-operative scores after controlling for pre-operative scores and patient characteristics. Study cohorts included 2070 OA and 142 RA patients for TKR and 2030 OA and 98 RA patients for THR. Following TKR, the median Oxford Knee Score was 37 [interquartile range (IQR) 29-43] for OA and 36 (27-42) for RA while the median EQ-5D-3L was 0.76 (0.69-1.00) and 0.69 (0.52-0.85), respectively. After THR, the Oxford Hip Score was 42 (IQR 36-46) for OA and 39 (30-44) for RA while the EQ-5D-3L was 0.85 (0.69-1.00) and 0.69 (0.52-1.00), respectively. The estimated effect of RA, relative to OA, on post-operative scores was -0.05 (95% CI -1.57, 1.48) for the Oxford Knee Score, -0.09 (-0.13, -0.06) for the EQ-5D-3L following TKR, -1.35 (-2.93, -0.22) for the Oxford Hip Score, and -0.08 (-0.12, -0.03) for the EQ-5D-3L following THR. TKR and THR led to substantial improvements in joint-specific scores and overall quality of life. While diagnosis had no clinically meaningful effect on joint-specific outcomes, improvements in general quality of life were somewhat less for those with RA, which is likely due to the systemic and multijoint nature of rheumatoid disease.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226288
https://dx.doi.org/urn:doi:10.1093/rheumatology/key409
url https://ddd.uab.cat/record/226288
https://dx.doi.org/urn:doi:10.1093/rheumatology/key409
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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