Diagnosis and management of the antiphospholipid syndrome

The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. Thrombotic antiphospholipid syndrome is characterized by venous, arterial, or microvascular thrombosis. Patients with catastr...

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Authors: Riera Mestre, Antoni, Vidaller Palacín, Antonio
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/178505
Online Access:https://hdl.handle.net/2445/178505
Access Level:Open access
Keyword:Síndrome antifosfolipídica
Diagnòstic
Trombosi
Antiphospholipid syndrome
Diagnosis
Thrombosis
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spelling Diagnosis and management of the antiphospholipid syndromeRiera Mestre, AntoniVidaller Palacín, AntonioSíndrome antifosfolipídicaDiagnòsticTrombosiAntiphospholipid syndromeDiagnosisThrombosisThe antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. Thrombotic antiphospholipid syndrome is characterized by venous, arterial, or microvascular thrombosis. Patients with catastrophic antiphospholipid syndrome present with thrombosis involving multiple organs. Obstetrical antiphospholipid syndrome is characterized by fetal loss after the 10th week of gestation, recurrent early miscarriages, intrauterine growth restriction, or severe preeclampsia.1 The major nonthrombotic manifestations of antiphospholipid-antibody positivity include valvular heart disease, livedo, antiphospholipidantibody-related nephropathy, thrombocytopenia, hemolytic anemia, and cognitive dysfunction. The antiphospholipid syndrome is often associated with other systemic autoimmune diseases such as systemic lupus erythematosus (SLE); however, it commonly occurs without other autoimmune manifestations (primary antiphospholipid syndrome).Massachusetts Medical Society2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/178505Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1056/NEJMc1808253New England Journal of Medicine, 2018, vol. 379, num. 13, p. 1289-1290https://doi.org/10.1056/NEJMc1808253(c) Massachusetts Medical Society, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1785052026-05-27T06:46:51Z
dc.title.none.fl_str_mv Diagnosis and management of the antiphospholipid syndrome
title Diagnosis and management of the antiphospholipid syndrome
spellingShingle Diagnosis and management of the antiphospholipid syndrome
Riera Mestre, Antoni
Síndrome antifosfolipídica
Diagnòstic
Trombosi
Antiphospholipid syndrome
Diagnosis
Thrombosis
title_short Diagnosis and management of the antiphospholipid syndrome
title_full Diagnosis and management of the antiphospholipid syndrome
title_fullStr Diagnosis and management of the antiphospholipid syndrome
title_full_unstemmed Diagnosis and management of the antiphospholipid syndrome
title_sort Diagnosis and management of the antiphospholipid syndrome
dc.creator.none.fl_str_mv Riera Mestre, Antoni
Vidaller Palacín, Antonio
author Riera Mestre, Antoni
author_facet Riera Mestre, Antoni
Vidaller Palacín, Antonio
author_role author
author2 Vidaller Palacín, Antonio
author2_role author
dc.subject.none.fl_str_mv Síndrome antifosfolipídica
Diagnòstic
Trombosi
Antiphospholipid syndrome
Diagnosis
Thrombosis
topic Síndrome antifosfolipídica
Diagnòstic
Trombosi
Antiphospholipid syndrome
Diagnosis
Thrombosis
description The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. Thrombotic antiphospholipid syndrome is characterized by venous, arterial, or microvascular thrombosis. Patients with catastrophic antiphospholipid syndrome present with thrombosis involving multiple organs. Obstetrical antiphospholipid syndrome is characterized by fetal loss after the 10th week of gestation, recurrent early miscarriages, intrauterine growth restriction, or severe preeclampsia.1 The major nonthrombotic manifestations of antiphospholipid-antibody positivity include valvular heart disease, livedo, antiphospholipidantibody-related nephropathy, thrombocytopenia, hemolytic anemia, and cognitive dysfunction. The antiphospholipid syndrome is often associated with other systemic autoimmune diseases such as systemic lupus erythematosus (SLE); however, it commonly occurs without other autoimmune manifestations (primary antiphospholipid syndrome).
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178505
url https://hdl.handle.net/2445/178505
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1056/NEJMc1808253
New England Journal of Medicine, 2018, vol. 379, num. 13, p. 1289-1290
https://doi.org/10.1056/NEJMc1808253
dc.rights.none.fl_str_mv (c) Massachusetts Medical Society, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Massachusetts Medical Society, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Massachusetts Medical Society
publisher.none.fl_str_mv Massachusetts Medical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410503331151873
score 15,300719

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