Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables

Gambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD...

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Authors: Solé Morata, Neus, Baenas, Isabel, Etxandi, Mikel, Granero, Roser, Gené, Manel, Barrot i Feixat, Carme, Gómez-Peña, Mónica, Moragas, Laura, Ramoz, Nicolás, Gorwood, Philip, Fernández Aranda, Fernando, Jiménez-Murcia, Susana
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/197203
Online Access:https://hdl.handle.net/2445/197203
Access Level:Open access
Keyword:Joc compulsiu
Psicopatologia
Personalitat
Genètica
Compulsive gambling
Pathological psychology
Personality
Genetics
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spelling Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variablesSolé Morata, NeusBaenas, IsabelEtxandi, MikelGranero, RoserGené, ManelBarrot i Feixat, CarmeGómez-Peña, MónicaMoragas, LauraRamoz, NicolásGorwood, PhilipFernández Aranda, FernandoJiménez-Murcia, SusanaJoc compulsiuPsicopatologiaPersonalitatGenèticaCompulsive gamblingPathological psychologyPersonalityGeneticsGambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD severity by considering the direct and mediational relationship between different variables including genetic, psychological, socio-demographic, and clinical factors. To do so, we used genetic variants that were significantly associated with an increased risk for GD and evaluated its relationship with GD severity through pathway analysis. We found that the interaction between these genetic variants and other different biopsychological features predicted a higher severity of GD. On the one hand, the presence of haplotype block 2, interrelated with haplotype block 3, was linked to a more dysfunctional personality profile and a worse psychopathological state, which, in turn, had a direct link with GD severity. On the other hand, having rs3763614 predicted higher general psychopathology and therefore, higher GD severity. The current study described the presence of complex interactions between biopsychosocial variables previously associated with the etiopathogenesis and severity of GD, while also supporting the involvement of genetic variants from the NTF family.MDPI2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/197203Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu15020418Nutrients, 2023, vol. 15, num. 2https://doi.org/10.3390/nu15020418cc-by (c) Solé-morata, Neus et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1972032026-05-29T05:05:01Z
dc.title.none.fl_str_mv Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
title Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
spellingShingle Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
Solé Morata, Neus
Joc compulsiu
Psicopatologia
Personalitat
Genètica
Compulsive gambling
Pathological psychology
Personality
Genetics
title_short Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
title_full Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
title_fullStr Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
title_full_unstemmed Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
title_sort Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables
dc.creator.none.fl_str_mv Solé Morata, Neus
Baenas, Isabel
Etxandi, Mikel
Granero, Roser
Gené, Manel
Barrot i Feixat, Carme
Gómez-Peña, Mónica
Moragas, Laura
Ramoz, Nicolás
Gorwood, Philip
Fernández Aranda, Fernando
Jiménez-Murcia, Susana
author Solé Morata, Neus
author_facet Solé Morata, Neus
Baenas, Isabel
Etxandi, Mikel
Granero, Roser
Gené, Manel
Barrot i Feixat, Carme
Gómez-Peña, Mónica
Moragas, Laura
Ramoz, Nicolás
Gorwood, Philip
Fernández Aranda, Fernando
Jiménez-Murcia, Susana
author_role author
author2 Baenas, Isabel
Etxandi, Mikel
Granero, Roser
Gené, Manel
Barrot i Feixat, Carme
Gómez-Peña, Mónica
Moragas, Laura
Ramoz, Nicolás
Gorwood, Philip
Fernández Aranda, Fernando
Jiménez-Murcia, Susana
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Joc compulsiu
Psicopatologia
Personalitat
Genètica
Compulsive gambling
Pathological psychology
Personality
Genetics
topic Joc compulsiu
Psicopatologia
Personalitat
Genètica
Compulsive gambling
Pathological psychology
Personality
Genetics
description Gambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD severity by considering the direct and mediational relationship between different variables including genetic, psychological, socio-demographic, and clinical factors. To do so, we used genetic variants that were significantly associated with an increased risk for GD and evaluated its relationship with GD severity through pathway analysis. We found that the interaction between these genetic variants and other different biopsychological features predicted a higher severity of GD. On the one hand, the presence of haplotype block 2, interrelated with haplotype block 3, was linked to a more dysfunctional personality profile and a worse psychopathological state, which, in turn, had a direct link with GD severity. On the other hand, having rs3763614 predicted higher general psychopathology and therefore, higher GD severity. The current study described the presence of complex interactions between biopsychosocial variables previously associated with the etiopathogenesis and severity of GD, while also supporting the involvement of genetic variants from the NTF family.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/197203
url https://hdl.handle.net/2445/197203
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu15020418
Nutrients, 2023, vol. 15, num. 2
https://doi.org/10.3390/nu15020418
dc.rights.none.fl_str_mv cc-by (c) Solé-morata, Neus et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Solé-morata, Neus et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410502893895680
score 15,811543

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