P53 expression correlates with low axillary tumor burden in breast cancer

Background: The p53 mutation in breast cancer confers a worse prognosis and is usually associated with p53 overexpression (p53+) on immunohistochemistry. Previous studies have shown that p53+ tumors could be associated with low axillary tumor burden (ATB). Objective: We aimed to evaluate the associa...

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Detalhes bibliográficos
Autores: Nicolau, Pau, Masó, Paula, Argudo Aguirre, Nuria, Jiménez Gómez, Marta, Martínez, Anabel, Vázquez, Ivonne, Comerma Blesa, Laura, 1983-, Vernet-Tomás, Maria
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/61415
Acesso em linha:http://hdl.handle.net/10230/61415
http://dx.doi.org/10.3233/BD-230013
Access Level:acceso abierto
Palavra-chave:Axillary tumor burden
Breast cancer
Immunophenotypes
p53
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repository_id_str
spelling P53 expression correlates with low axillary tumor burden in breast cancerNicolau, PauMasó, PaulaArgudo Aguirre, NuriaJiménez Gómez, MartaMartínez, AnabelVázquez, IvonneComerma Blesa, Laura, 1983-Vernet-Tomás, MariaAxillary tumor burdenBreast cancerImmunophenotypesp53Background: The p53 mutation in breast cancer confers a worse prognosis and is usually associated with p53 overexpression (p53+) on immunohistochemistry. Previous studies have shown that p53+ tumors could be associated with low axillary tumor burden (ATB). Objective: We aimed to evaluate the association between p53+ and ATB in a large series of breast cancers as an aid to personalizing axillary surgical treatment. Methods: We retrieved 1762 infiltrating breast carcinomas from our database that were treated with upfront surgery in Hospital del Mar from 2004 to 2018. We compared p53+ and p53-negative (p53-) tumors in terms of the percentage of cases with high ATB and overall survival. This comparison was made overall and for each immunophenotype. Results: Overall, 18.7% of breast tumors were p53+. High ATB was less common in p53+ tumors than in p53- tumors in the luminal B-Her2-negative immunophenotype (6.2% versus 16.9%, respectively, P = 0.025), but not in the other immunophenotypes or overall. Overall survival was worse in patients with p53+ breast cancer (P = 0.002). Conclusion: p53+ breast cancers were associated with worse overall survival. However, low ATB was more common in these tumors than in p53- tumors in the luminal B-Her2-negative subtype. Information on p53 expression could be of use to predict ATB in some breast cancer tumors.IOS Press202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/61415http://dx.doi.org/10.3233/BD-230013reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBreast Dis. 2023;42(1):429-35The final publication is available at IOS Press through http://dx.doi.org/10.3233/BD-230013info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/614152026-06-12T07:21:37Z
dc.title.none.fl_str_mv P53 expression correlates with low axillary tumor burden in breast cancer
title P53 expression correlates with low axillary tumor burden in breast cancer
spellingShingle P53 expression correlates with low axillary tumor burden in breast cancer
Nicolau, Pau
Axillary tumor burden
Breast cancer
Immunophenotypes
p53
title_short P53 expression correlates with low axillary tumor burden in breast cancer
title_full P53 expression correlates with low axillary tumor burden in breast cancer
title_fullStr P53 expression correlates with low axillary tumor burden in breast cancer
title_full_unstemmed P53 expression correlates with low axillary tumor burden in breast cancer
title_sort P53 expression correlates with low axillary tumor burden in breast cancer
dc.creator.none.fl_str_mv Nicolau, Pau
Masó, Paula
Argudo Aguirre, Nuria
Jiménez Gómez, Marta
Martínez, Anabel
Vázquez, Ivonne
Comerma Blesa, Laura, 1983-
Vernet-Tomás, Maria
author Nicolau, Pau
author_facet Nicolau, Pau
Masó, Paula
Argudo Aguirre, Nuria
Jiménez Gómez, Marta
Martínez, Anabel
Vázquez, Ivonne
Comerma Blesa, Laura, 1983-
Vernet-Tomás, Maria
author_role author
author2 Masó, Paula
Argudo Aguirre, Nuria
Jiménez Gómez, Marta
Martínez, Anabel
Vázquez, Ivonne
Comerma Blesa, Laura, 1983-
Vernet-Tomás, Maria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Axillary tumor burden
Breast cancer
Immunophenotypes
p53
topic Axillary tumor burden
Breast cancer
Immunophenotypes
p53
description Background: The p53 mutation in breast cancer confers a worse prognosis and is usually associated with p53 overexpression (p53+) on immunohistochemistry. Previous studies have shown that p53+ tumors could be associated with low axillary tumor burden (ATB). Objective: We aimed to evaluate the association between p53+ and ATB in a large series of breast cancers as an aid to personalizing axillary surgical treatment. Methods: We retrieved 1762 infiltrating breast carcinomas from our database that were treated with upfront surgery in Hospital del Mar from 2004 to 2018. We compared p53+ and p53-negative (p53-) tumors in terms of the percentage of cases with high ATB and overall survival. This comparison was made overall and for each immunophenotype. Results: Overall, 18.7% of breast tumors were p53+. High ATB was less common in p53+ tumors than in p53- tumors in the luminal B-Her2-negative immunophenotype (6.2% versus 16.9%, respectively, P = 0.025), but not in the other immunophenotypes or overall. Overall survival was worse in patients with p53+ breast cancer (P = 0.002). Conclusion: p53+ breast cancers were associated with worse overall survival. However, low ATB was more common in these tumors than in p53- tumors in the luminal B-Her2-negative subtype. Information on p53 expression could be of use to predict ATB in some breast cancer tumors.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/61415
http://dx.doi.org/10.3233/BD-230013
url http://hdl.handle.net/10230/61415
http://dx.doi.org/10.3233/BD-230013
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Breast Dis. 2023;42(1):429-35
dc.rights.none.fl_str_mv The final publication is available at IOS Press through http://dx.doi.org/10.3233/BD-230013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv The final publication is available at IOS Press through http://dx.doi.org/10.3233/BD-230013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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