3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccha...

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Autores: Zarandona Rodríguez, Iratxe, Bengoechea, Carlos, Álvarez Castillo, Estefanía, De la Caba Ciriza, María Coro, Guerrero, Antonio, Guerrero Manso, Pedro Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/54742
Acceso en línea:http://hdl.handle.net/10810/54742
Access Level:acceso abierto
Palabra clave:chitosan
pectin
3D printing
rheology
scaffolds
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spelling 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and AssessmentZarandona Rodríguez, IratxeBengoechea, CarlosÁlvarez Castillo, EstefaníaDe la Caba Ciriza, María CoroGuerrero, AntonioGuerrero Manso, Pedro Manuelchitosanpectin3D printingrheologyscaffoldsChitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.This research was funded by MCI/AEI/FEDER, UE, grant number RTI2018-097100-B-C21 and RTI2018-097100-B-C22.MDPI2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/54742reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MCI/RTI2018-097100-B-C21/info:eu-repo/grantAgreement/MCI/RTI2018-097100-B-C22/https://www.mdpi.com/2310-2861/7/4/175info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/547422026-06-18T09:23:17Z
dc.title.none.fl_str_mv 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
title 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
spellingShingle 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
Zarandona Rodríguez, Iratxe
chitosan
pectin
3D printing
rheology
scaffolds
title_short 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
title_full 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
title_fullStr 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
title_full_unstemmed 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
title_sort 3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment
dc.creator.none.fl_str_mv Zarandona Rodríguez, Iratxe
Bengoechea, Carlos
Álvarez Castillo, Estefanía
De la Caba Ciriza, María Coro
Guerrero, Antonio
Guerrero Manso, Pedro Manuel
author Zarandona Rodríguez, Iratxe
author_facet Zarandona Rodríguez, Iratxe
Bengoechea, Carlos
Álvarez Castillo, Estefanía
De la Caba Ciriza, María Coro
Guerrero, Antonio
Guerrero Manso, Pedro Manuel
author_role author
author2 Bengoechea, Carlos
Álvarez Castillo, Estefanía
De la Caba Ciriza, María Coro
Guerrero, Antonio
Guerrero Manso, Pedro Manuel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv chitosan
pectin
3D printing
rheology
scaffolds
topic chitosan
pectin
3D printing
rheology
scaffolds
description Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/54742
url http://hdl.handle.net/10810/54742
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MCI/RTI2018-097100-B-C21/
info:eu-repo/grantAgreement/MCI/RTI2018-097100-B-C22/
https://www.mdpi.com/2310-2861/7/4/175
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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