Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise

Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether...

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Autores: Ruiz Iglesias, Patricia, Estruel Amades, Seila, Camps i Bossacoma, Mariona, Massot Cladera, Malen, Franch i Masferrer, Àngels, Pérez-Cano, Francisco J., Castell, Margarida
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/164433
Acceso en línea:https://hdl.handle.net/2445/164433
Access Level:acceso abierto
Palabra clave:Exercici
Fatiga
Cèl·lules K
Sistema immunitari
Estrès oxidatiu
Sang
Rates (Animals de laboratori)
Melsa
Macròfags
Fagocitosi
Exercise
Fatigue
Killer cells
Immune system
Oxidative stress
Blood
Rats as laboratory animals
Spleen
Macrophages
Phagocytosis
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repository_id_str
spelling Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exerciseRuiz Iglesias, PatriciaEstruel Amades, SeilaCamps i Bossacoma, MarionaMassot Cladera, MalenFranch i Masferrer, ÀngelsPérez-Cano, Francisco J.Castell, MargaridaExerciciFatigaCèl·lules KSistema immunitariEstrès oxidatiuSangRates (Animals de laboratori)MelsaMacròfagsFagocitosiExerciseFatigueKiller cellsImmune systemOxidative stressBloodRats as laboratory animalsSpleenMacrophagesPhagocytosisIntensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the e ect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alteration.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/164433Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu12051291Nutrients, 2020, vol. 12, num. 5, p. E1291https://doi.org/10.3390/nu12051291cc-by (c) Ruiz-Iglesias, Patricia et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1644332026-05-27T06:46:51Z
dc.title.none.fl_str_mv Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
title Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
spellingShingle Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
Ruiz Iglesias, Patricia
Exercici
Fatiga
Cèl·lules K
Sistema immunitari
Estrès oxidatiu
Sang
Rates (Animals de laboratori)
Melsa
Macròfags
Fagocitosi
Exercise
Fatigue
Killer cells
Immune system
Oxidative stress
Blood
Rats as laboratory animals
Spleen
Macrophages
Phagocytosis
title_short Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
title_full Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
title_fullStr Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
title_full_unstemmed Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
title_sort Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
dc.creator.none.fl_str_mv Ruiz Iglesias, Patricia
Estruel Amades, Seila
Camps i Bossacoma, Mariona
Massot Cladera, Malen
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author Ruiz Iglesias, Patricia
author_facet Ruiz Iglesias, Patricia
Estruel Amades, Seila
Camps i Bossacoma, Mariona
Massot Cladera, Malen
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author_role author
author2 Estruel Amades, Seila
Camps i Bossacoma, Mariona
Massot Cladera, Malen
Franch i Masferrer, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Exercici
Fatiga
Cèl·lules K
Sistema immunitari
Estrès oxidatiu
Sang
Rates (Animals de laboratori)
Melsa
Macròfags
Fagocitosi
Exercise
Fatigue
Killer cells
Immune system
Oxidative stress
Blood
Rats as laboratory animals
Spleen
Macrophages
Phagocytosis
topic Exercici
Fatiga
Cèl·lules K
Sistema immunitari
Estrès oxidatiu
Sang
Rates (Animals de laboratori)
Melsa
Macròfags
Fagocitosi
Exercise
Fatigue
Killer cells
Immune system
Oxidative stress
Blood
Rats as laboratory animals
Spleen
Macrophages
Phagocytosis
description Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the e ect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alteration.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/164433
url https://hdl.handle.net/2445/164433
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu12051291
Nutrients, 2020, vol. 12, num. 5, p. E1291
https://doi.org/10.3390/nu12051291
dc.rights.none.fl_str_mv cc-by (c) Ruiz-Iglesias, Patricia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ruiz-Iglesias, Patricia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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