On the plasma deposition of vancomycin-containing nano-capsules for drug-delivery applications
Aerosol-assisted atmospheric pressure plasma allows for a one-step synthesis of vancomycin-containing nano-capsules. Morphological and chemical analyses are carried out to estimate how different discharge parameters affect the plasma deposition process. Nano-capsules size and abundance largely depen...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/117820 |
| Acceso en línea: | https://hdl.handle.net/2117/117820 https://dx.doi.org/10.1002/ppap.201700232 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomedical materials Plasma Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials |
| Sumario: | Aerosol-assisted atmospheric pressure plasma allows for a one-step synthesis of vancomycin-containing nano-capsules. Morphological and chemical analyses are carried out to estimate how different discharge parameters affect the plasma deposition process. Nano-capsules size and abundance largely depend on the shell precursor content in the gas feed and on the drug concentration in the aerosol solution. Based on these results a deposition mechanism is proposed, where, interestingly, the key step is the formation of the nano-capsules in the plasma phase. Furthermore, the related antibacterial activity is proved against Staphylococcus aureus. Preliminary release tests indicate the possible exploitation of the plasma-deposited vancomycin-containing nano-capsules in the drug delivery field, and systems based on other bioactive molecules can be expected. |
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