Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer

Background HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associated with a more aggressive phenotype in several cancers. However, the progno...

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Autores: Navarro Ponz, Alfons, Moisés, Jorge, Santasusagna, Sandra, Marrades Sicart, Ramon Ma., Viñolas Segarra, Núria, Castellano, Joan Josep, Canals, Jordi, Muñoz García, Carmen, Ramirez, José, Molins López-Rodó, Laureano, Monzó Planella, Mariano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/130991
Acceso en línea:https://hdl.handle.net/2445/130991
Access Level:acceso abierto
Palabra clave:Càncer de pulmó
RNA
Lung cancer
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spelling Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancerNavarro Ponz, AlfonsMoisés, JorgeSantasusagna, SandraMarrades Sicart, Ramon Ma.Viñolas Segarra, NúriaCastellano, Joan JosepCanals, JordiMuñoz García, CarmenRamirez, JoséMolins López-Rodó, LaureanoMonzó Planella, MarianoCàncer de pulmóRNALung cancerRNABackground HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associated with a more aggressive phenotype in several cancers. However, the prognostic impact of HOTTIP has not yet been explored in non-small-cell lung cancer (NSCLC). We have correlated HOTTIP expression with time to relapse (TTR) and overall survival (OS) in early-stage NSCLC patients. Methods Ninety-nine early-stage NSCLC patients who underwent surgical resection in our center from June 2007 to November 2013 were included in the study. Mean age was 66; 77.8% were males; 73.7% had stage I disease; and 55.5% had adenocarcinoma. A validation data set comprised stage I-II patients from The Cancer Genome Atlas (TCGA) Research Network. Results HOTTIP was expressed in all tumor samples and was overexpressed in squamous cell carcinoma (p = 0.007) and in smokers (p = 0.018). Patients with high levels of HOTTIP had shorter TTR (78.3 vs 58 months; p = 0.048) and shorter OS (81.2 vs 61 months; p = 0.023) than those with low levels. In the multivariate analysis, HOTTIP emerged as an independent prognostic marker for TTR (OR: 2.05, 95%CI: 1-4.2; p = 0.05), and for OS (OR: 2.31, 95%CI: 1.04-5.1; p = 0.04). HOTTIP was validated as a prognostic marker for OS in the TCGA adenocarcinoma cohort (p = 0.025). Moreover, we identified a 1203-mRNA and a 61-miRNA signature that correlated with HOTTIP expression. Conclusions The lncRNA HOTTIP can be considered a prognostic biomarker in early-stage NSCLC.BioMed Central2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/130991Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s12890-019-0816-8BMC Pulmonary Medicine, 2019, vol. 19, num. 1, p. 55-63https://doi.org/10.1186/s12890-019-0816-8cc-by (c) Navarro Ponz, Alfons et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1309912026-05-27T06:46:51Z
dc.title.none.fl_str_mv Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
title Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
spellingShingle Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
Navarro Ponz, Alfons
Càncer de pulmó
RNA
Lung cancer
RNA
title_short Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
title_full Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
title_fullStr Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
title_full_unstemmed Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
title_sort Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
dc.creator.none.fl_str_mv Navarro Ponz, Alfons
Moisés, Jorge
Santasusagna, Sandra
Marrades Sicart, Ramon Ma.
Viñolas Segarra, Núria
Castellano, Joan Josep
Canals, Jordi
Muñoz García, Carmen
Ramirez, José
Molins López-Rodó, Laureano
Monzó Planella, Mariano
author Navarro Ponz, Alfons
author_facet Navarro Ponz, Alfons
Moisés, Jorge
Santasusagna, Sandra
Marrades Sicart, Ramon Ma.
Viñolas Segarra, Núria
Castellano, Joan Josep
Canals, Jordi
Muñoz García, Carmen
Ramirez, José
Molins López-Rodó, Laureano
Monzó Planella, Mariano
author_role author
author2 Moisés, Jorge
Santasusagna, Sandra
Marrades Sicart, Ramon Ma.
Viñolas Segarra, Núria
Castellano, Joan Josep
Canals, Jordi
Muñoz García, Carmen
Ramirez, José
Molins López-Rodó, Laureano
Monzó Planella, Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de pulmó
RNA
Lung cancer
RNA
topic Càncer de pulmó
RNA
Lung cancer
RNA
description Background HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associated with a more aggressive phenotype in several cancers. However, the prognostic impact of HOTTIP has not yet been explored in non-small-cell lung cancer (NSCLC). We have correlated HOTTIP expression with time to relapse (TTR) and overall survival (OS) in early-stage NSCLC patients. Methods Ninety-nine early-stage NSCLC patients who underwent surgical resection in our center from June 2007 to November 2013 were included in the study. Mean age was 66; 77.8% were males; 73.7% had stage I disease; and 55.5% had adenocarcinoma. A validation data set comprised stage I-II patients from The Cancer Genome Atlas (TCGA) Research Network. Results HOTTIP was expressed in all tumor samples and was overexpressed in squamous cell carcinoma (p = 0.007) and in smokers (p = 0.018). Patients with high levels of HOTTIP had shorter TTR (78.3 vs 58 months; p = 0.048) and shorter OS (81.2 vs 61 months; p = 0.023) than those with low levels. In the multivariate analysis, HOTTIP emerged as an independent prognostic marker for TTR (OR: 2.05, 95%CI: 1-4.2; p = 0.05), and for OS (OR: 2.31, 95%CI: 1.04-5.1; p = 0.04). HOTTIP was validated as a prognostic marker for OS in the TCGA adenocarcinoma cohort (p = 0.025). Moreover, we identified a 1203-mRNA and a 61-miRNA signature that correlated with HOTTIP expression. Conclusions The lncRNA HOTTIP can be considered a prognostic biomarker in early-stage NSCLC.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130991
url https://hdl.handle.net/2445/130991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12890-019-0816-8
BMC Pulmonary Medicine, 2019, vol. 19, num. 1, p. 55-63
https://doi.org/10.1186/s12890-019-0816-8
dc.rights.none.fl_str_mv cc-by (c) Navarro Ponz, Alfons et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Navarro Ponz, Alfons et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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