Innate immune receptors, key actors in cardiovascular diseases

Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with increased inflammation that arises mainly from innate immune system activation related to cardiac damage. Sustained activation of the innate immune system frequently results in ma...

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Detalles Bibliográficos
Autores: Jaén, Rafael I., Val-Blasco, Almudena, Prieto, Patricia, Gil-Fernández, Marta, Smani, Tarik, López-Sendón Hentschel, José Luis, Delgado, Carmen, Boscá, Lisardo, Fernández-Velasco, María
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/696478
Acceso en línea:http://hdl.handle.net/10486/696478
https://dx.doi.org/10.1016/j.jacbts.2020.03.015
Access Level:acceso abierto
Palabra clave:cardiovascular disease
innate immune system
NLRP3
NOD1
nucleotide-binding oligomerization domain-like receptors
toll-like receptors
Medicina
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spelling Innate immune receptors, key actors in cardiovascular diseasesJaén, Rafael I.Val-Blasco, AlmudenaPrieto, PatriciaGil-Fernández, MartaSmani, TarikLópez-Sendón Hentschel, José LuisDelgado, CarmenBoscá, LisardoFernández-Velasco, Maríacardiovascular diseaseinnate immune systemNLRP3NOD1nucleotide-binding oligomerization domain-like receptorstoll-like receptorsMedicinaCardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with increased inflammation that arises mainly from innate immune system activation related to cardiac damage. Sustained activation of the innate immune system frequently results in maladaptive inflammatory responses that promote cardiovascular dysfunction and remodeling. Much research has focused on determining whether some mediators of the innate immune system are potential targets for CVD therapy. The innate immune system has specific receptors—termed pattern recognition receptors (PRRs)—that not only recognize pathogen-associated molecular patterns, but also sense danger-associated molecular signals. Activation of PRRs triggers the inflammatory response in different physiological systems, including the cardiovascular system. The classic PRRs, toll-like receptors (TLRs), and the more recently discovered nucleotide-binding oligomerization domain-like receptors (NLRs), have been recently proposed as key partners in the progression of several CVDs (e.g., atherosclerosis and heart failure). The present review discusses the key findings related to the involvement of TLRs and NLRs in the progression of several vascular and cardiac diseases, with a focus on whether some NLR subtypes (nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing receptor 3 and nucleotide-binding oligomerization domain-containing protein 1) can be candidates for the development of new therapeutic strategies for several CVDs.Elsevier on behalf of the American College of Cardiology FoundationDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ)20202020-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/696478https://dx.doi.org/10.1016/j.jacbts.2020.03.015reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6964782026-06-23T12:46:27Z
dc.title.none.fl_str_mv Innate immune receptors, key actors in cardiovascular diseases
title Innate immune receptors, key actors in cardiovascular diseases
spellingShingle Innate immune receptors, key actors in cardiovascular diseases
Jaén, Rafael I.
cardiovascular disease
innate immune system
NLRP3
NOD1
nucleotide-binding oligomerization domain-like receptors
toll-like receptors
Medicina
title_short Innate immune receptors, key actors in cardiovascular diseases
title_full Innate immune receptors, key actors in cardiovascular diseases
title_fullStr Innate immune receptors, key actors in cardiovascular diseases
title_full_unstemmed Innate immune receptors, key actors in cardiovascular diseases
title_sort Innate immune receptors, key actors in cardiovascular diseases
dc.creator.none.fl_str_mv Jaén, Rafael I.
Val-Blasco, Almudena
Prieto, Patricia
Gil-Fernández, Marta
Smani, Tarik
López-Sendón Hentschel, José Luis
Delgado, Carmen
Boscá, Lisardo
Fernández-Velasco, María
author Jaén, Rafael I.
author_facet Jaén, Rafael I.
Val-Blasco, Almudena
Prieto, Patricia
Gil-Fernández, Marta
Smani, Tarik
López-Sendón Hentschel, José Luis
Delgado, Carmen
Boscá, Lisardo
Fernández-Velasco, María
author_role author
author2 Val-Blasco, Almudena
Prieto, Patricia
Gil-Fernández, Marta
Smani, Tarik
López-Sendón Hentschel, José Luis
Delgado, Carmen
Boscá, Lisardo
Fernández-Velasco, María
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ)
dc.subject.none.fl_str_mv cardiovascular disease
innate immune system
NLRP3
NOD1
nucleotide-binding oligomerization domain-like receptors
toll-like receptors
Medicina
topic cardiovascular disease
innate immune system
NLRP3
NOD1
nucleotide-binding oligomerization domain-like receptors
toll-like receptors
Medicina
description Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with increased inflammation that arises mainly from innate immune system activation related to cardiac damage. Sustained activation of the innate immune system frequently results in maladaptive inflammatory responses that promote cardiovascular dysfunction and remodeling. Much research has focused on determining whether some mediators of the innate immune system are potential targets for CVD therapy. The innate immune system has specific receptors—termed pattern recognition receptors (PRRs)—that not only recognize pathogen-associated molecular patterns, but also sense danger-associated molecular signals. Activation of PRRs triggers the inflammatory response in different physiological systems, including the cardiovascular system. The classic PRRs, toll-like receptors (TLRs), and the more recently discovered nucleotide-binding oligomerization domain-like receptors (NLRs), have been recently proposed as key partners in the progression of several CVDs (e.g., atherosclerosis and heart failure). The present review discusses the key findings related to the involvement of TLRs and NLRs in the progression of several vascular and cardiac diseases, with a focus on whether some NLR subtypes (nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing receptor 3 and nucleotide-binding oligomerization domain-containing protein 1) can be candidates for the development of new therapeutic strategies for several CVDs.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-07-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/696478
https://dx.doi.org/10.1016/j.jacbts.2020.03.015
url http://hdl.handle.net/10486/696478
https://dx.doi.org/10.1016/j.jacbts.2020.03.015
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier on behalf of the American College of Cardiology Foundation
publisher.none.fl_str_mv Elsevier on behalf of the American College of Cardiology Foundation
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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