NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

[EN] Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal of this study was to evaluate the effect of 2-year nutritional intervention with antioxidant nutraceuticals on the visual function of RP patients. Secondly, we assessed how nutritional interventi...

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Autores: Olivares-González, Lorena, Salom, David, González-García, Emilio, Mejía-Chiqui, Natalia, Melero, Mar, Velasco, Sheyla, Muresan, Bianca Tabita, Campillo, Isabel, Vila-Clérigues, Nieves, Lopez-Briz, Eduardo, Merino-Torres, Juan Francisco, Millán, José María, Soriano del Castillo, José Miguel, Rodrigo, Regina, Hervás-Marín, David|||0000-0003-0635-4961
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/199937
Acceso en línea:https://riunet.upv.es/handle/10251/199937
Access Level:acceso abierto
Palabra clave:Retinitis pigmentosa
Oxidative damage
Nutraceuticals
Antioxidants
Visual function
ESTADISTICA E INVESTIGACION OPERATIVA
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network_name_str España
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dc.title.none.fl_str_mv NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
title NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
spellingShingle NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
Olivares-González, Lorena
Retinitis pigmentosa
Oxidative damage
Nutraceuticals
Antioxidants
Visual function
ESTADISTICA E INVESTIGACION OPERATIVA
title_short NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
title_full NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
title_fullStr NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
title_full_unstemmed NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
title_sort NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial
dc.creator.none.fl_str_mv Olivares-González, Lorena
Salom, David
González-García, Emilio
Mejía-Chiqui, Natalia
Melero, Mar
Velasco, Sheyla
Muresan, Bianca Tabita
Campillo, Isabel
Vila-Clérigues, Nieves
Lopez-Briz, Eduardo
Merino-Torres, Juan Francisco
Millán, José María
Soriano del Castillo, José Miguel
Rodrigo, Regina
Hervás-Marín, David|||0000-0003-0635-4961
author Olivares-González, Lorena
author_facet Olivares-González, Lorena
Salom, David
González-García, Emilio
Mejía-Chiqui, Natalia
Melero, Mar
Velasco, Sheyla
Muresan, Bianca Tabita
Campillo, Isabel
Vila-Clérigues, Nieves
Lopez-Briz, Eduardo
Merino-Torres, Juan Francisco
Millán, José María
Soriano del Castillo, José Miguel
Rodrigo, Regina
Hervás-Marín, David|||0000-0003-0635-4961
author_role author
author2 Salom, David
González-García, Emilio
Mejía-Chiqui, Natalia
Melero, Mar
Velasco, Sheyla
Muresan, Bianca Tabita
Campillo, Isabel
Vila-Clérigues, Nieves
Lopez-Briz, Eduardo
Merino-Torres, Juan Francisco
Millán, José María
Soriano del Castillo, José Miguel
Rodrigo, Regina
Hervás-Marín, David|||0000-0003-0635-4961
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Estadística e Investigación Operativa Aplicadas y Calidad
Escuela Politécnica Superior de Alcoy
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
European Social Fund
Universitat de València
Instituto de Salud Carlos III
Ministerio de Sanidad y Consumo
European Regional Development Fund
Ministerio de Economía y Competitividad
Instituto de Investigación Sanitaria La Fe
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Retinitis pigmentosa
Oxidative damage
Nutraceuticals
Antioxidants
Visual function
ESTADISTICA E INVESTIGACION OPERATIVA
topic Retinitis pigmentosa
Oxidative damage
Nutraceuticals
Antioxidants
Visual function
ESTADISTICA E INVESTIGACION OPERATIVA
description [EN] Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal of this study was to evaluate the effect of 2-year nutritional intervention with antioxidant nutraceuticals on the visual function of RP patients. Secondly, we assessed how nutritional intervention affected ocular and systemic redox status. We carried out a randomized, double-blind, placebo-controlled study. Thirty-one patients with RP participated in the study. RP patients randomly received either a mixture of nutraceuticals (NUT) containing folic acid, vitamin B6, vitamin A, zinc, copper, selenium, lutein, and zeaxanthin or placebo daily for 2 years. At baseline and after 2-year of the nutritional supplementation, visual function, dietetic-nutritional evaluations, serum concentration of nutraceuticals, plasma and aqueous humor concentration of several markers of redox status and inflammation were assessed. Retinal function and structure were assessed by multifocal electroretinogram (mfERG), spectral domain-optical coherence tomography (SD-OCT) and automated visual field (VF) tests. Nutritional status was estimated with validated questionnaires. Total antioxidant capacity, extracellular superoxide dismutase (SOD3), catalase (CAT), and glutathione peroxidase (GPx) activities, protein carbonyl adducts (CAR) content, thiobarbituric acid reactive substances (TBARS) formation (as indicator of lipid peroxidation), metabolites of the nitric oxide (NOX) and cytokine (interleukin 6 and tumor necrosis factor alpha) concentrations were assessed by biochemical and immunological techniques in aqueous humor or/and blood. Bayesian approach was performed to determine the probability of an effect. Region of practical equivalence (ROPE) was used. At baseline, Bayesian analysis revealed a high probability of an altered ocular redox status and to a lesser extent systemic redox status in RP patients compared to controls. Twenty-five patients (10 in the treated arm and 15 in the placebo arm) completed the nutritional intervention. After 2 years of supplementation, patients who received NUT presented better retinal responses (mfERG responses) compared to patients who received placebo. Besides, patients who received NUT showed better ocular antioxidant response (SOD3 activity) and lower oxidative damage (CAR) than those who received placebo. This study suggested that long-term NUT supplementation could slow down visual impairment and ameliorate ocular oxidative stress.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/199937
url https://riunet.upv.es/handle/10251/199937
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 CP15%2F00019 CP15%2F00019
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18%2F00252
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 PI15%2F00052 Aplicación de la nanotecnología al tratamiento de la retinosis pigmentaria con anticuerpos anti-TNFa. Efecto sinérgico con antioxidantes
Ministerio de Sanidad y Consumo MSC CB06%2F07%2F1030 Sin Clasificar 145
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled TrialOlivares-González, LorenaSalom, DavidGonzález-García, EmilioMejía-Chiqui, NataliaMelero, MarVelasco, SheylaMuresan, Bianca TabitaCampillo, IsabelVila-Clérigues, NievesLopez-Briz, EduardoMerino-Torres, Juan FranciscoMillán, José MaríaSoriano del Castillo, José MiguelRodrigo, ReginaHervás-Marín, David|||0000-0003-0635-4961Retinitis pigmentosaOxidative damageNutraceuticalsAntioxidantsVisual functionESTADISTICA E INVESTIGACION OPERATIVA[EN] Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal of this study was to evaluate the effect of 2-year nutritional intervention with antioxidant nutraceuticals on the visual function of RP patients. Secondly, we assessed how nutritional intervention affected ocular and systemic redox status. We carried out a randomized, double-blind, placebo-controlled study. Thirty-one patients with RP participated in the study. RP patients randomly received either a mixture of nutraceuticals (NUT) containing folic acid, vitamin B6, vitamin A, zinc, copper, selenium, lutein, and zeaxanthin or placebo daily for 2 years. At baseline and after 2-year of the nutritional supplementation, visual function, dietetic-nutritional evaluations, serum concentration of nutraceuticals, plasma and aqueous humor concentration of several markers of redox status and inflammation were assessed. Retinal function and structure were assessed by multifocal electroretinogram (mfERG), spectral domain-optical coherence tomography (SD-OCT) and automated visual field (VF) tests. Nutritional status was estimated with validated questionnaires. Total antioxidant capacity, extracellular superoxide dismutase (SOD3), catalase (CAT), and glutathione peroxidase (GPx) activities, protein carbonyl adducts (CAR) content, thiobarbituric acid reactive substances (TBARS) formation (as indicator of lipid peroxidation), metabolites of the nitric oxide (NOX) and cytokine (interleukin 6 and tumor necrosis factor alpha) concentrations were assessed by biochemical and immunological techniques in aqueous humor or/and blood. Bayesian approach was performed to determine the probability of an effect. Region of practical equivalence (ROPE) was used. At baseline, Bayesian analysis revealed a high probability of an altered ocular redox status and to a lesser extent systemic redox status in RP patients compared to controls. Twenty-five patients (10 in the treated arm and 15 in the placebo arm) completed the nutritional intervention. After 2 years of supplementation, patients who received NUT presented better retinal responses (mfERG responses) compared to patients who received placebo. Besides, patients who received NUT showed better ocular antioxidant response (SOD3 activity) and lower oxidative damage (CAR) than those who received placebo. This study suggested that long-term NUT supplementation could slow down visual impairment and ameliorate ocular oxidative stress.This work was supported by the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) Carlos III Health Institute (ISCIII) (Grant numbers: PI15/00052 and PI18/00252) and co-funded by the European Regional Development Fund (FEDER)/European Social Fund ¿A way to make Europe¿/¿Investing in your future.¿ It was also supported by the IIS La Fe-UV PROGRAMA VLC-BIOMED-I (NUTRARET) and by RETINA COMUNIDAD VALENCIANA. LO-G had an ISCIII CIBERER research contract CB06/07/1030; RR had an ISCIII Spanish National Health System (SNS) Miguel Servet Type II research contract (code: CP15/00019).Frontiers Media S.A.Departamento de Estadística e Investigación Operativa Aplicadas y CalidadEscuela Politécnica Superior de AlcoyEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalEuropean Social FundUniversitat de ValènciaInstituto de Salud Carlos IIIMinisterio de Sanidad y ConsumoEuropean Regional Development FundMinisterio de Economía y CompetitividadInstituto de Investigación Sanitaria La FeRepositorio Institucional de la Universitat Politècnica de València Riunet20222022-03-21journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/199937reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 CP15%2F00019 CP15%2F00019Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18%2F00252Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 PI15%2F00052 Aplicación de la nanotecnología al tratamiento de la retinosis pigmentaria con anticuerpos anti-TNFa. Efecto sinérgico con antioxidantesMinisterio de Sanidad y Consumo MSC CB06%2F07%2F1030 Sin Clasificar 145open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1999372026-06-13T07:49:27Z
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