Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts

Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is associated with poor metabolic health in children. We studied the association betw...

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Autores: Papadopoulou, Eleni, 1985-, Basagaña Flores, Xavier, Casas Sanahuja, Maribel, Fossati, Serena, Maitre, Léa, Sabidó Aguadé, Eduard, 1981-, Borràs, Eva, Urquiza, José M., Vrijheid, Martine, Chatzi, Leda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52260
Acceso en línea:http://hdl.handle.net/10230/52260
http://dx.doi.org/10.1016/j.envint.2021.106853
Access Level:acceso abierto
Palabra clave:Cor--Malalties
Infants -- Malalties
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oai_identifier_str oai:repositori.upf.edu:10230/52260
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
title Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
spellingShingle Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
Papadopoulou, Eleni, 1985-
Cor--Malalties
Infants -- Malalties
title_short Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
title_full Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
title_fullStr Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
title_full_unstemmed Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
title_sort Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
dc.creator.none.fl_str_mv Papadopoulou, Eleni, 1985-
Basagaña Flores, Xavier
Casas Sanahuja, Maribel
Fossati, Serena
Maitre, Léa
Sabidó Aguadé, Eduard, 1981-
Borràs, Eva
Urquiza, José M.
Vrijheid, Martine
Chatzi, Leda
author Papadopoulou, Eleni, 1985-
author_facet Papadopoulou, Eleni, 1985-
Basagaña Flores, Xavier
Casas Sanahuja, Maribel
Fossati, Serena
Maitre, Léa
Sabidó Aguadé, Eduard, 1981-
Borràs, Eva
Urquiza, José M.
Vrijheid, Martine
Chatzi, Leda
author_role author
author2 Basagaña Flores, Xavier
Casas Sanahuja, Maribel
Fossati, Serena
Maitre, Léa
Sabidó Aguadé, Eduard, 1981-
Borràs, Eva
Urquiza, José M.
Vrijheid, Martine
Chatzi, Leda
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cor--Malalties
Infants -- Malalties
topic Cor--Malalties
Infants -- Malalties
description Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is associated with poor metabolic health in children. We studied the association between prenatal and postnatal PFASs mixture exposure and cardiometabolic health in children, and the role of inflammatory proteins. In 1,101 mothers-child pairs from the Human Early Life Exposome project, we measured the concentrations of PFAS in blood collected in pregnancy and at 8 years (range = 6-12 years). We applied Bayesian Kernel Machine regression (BKMR) to estimate the associations between exposure to PFAS mixture and the cardiometabolic factors as age and sex- specific z-scores of waist circumference (WC), systolic and diastolic blood pressures (BP), and concentrations of triglycerides (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) cholesterol. We measured thirty six inflammatory biomarkers in child plasma and examined the underlying role of inflammatory status for the exposure-outcome association by integrating the three panels into a network. Exposure to the PFAS mixture was positively associated with HDL-C and systolic BP, and negatively associated with WC, LDL-C and TG. When we examined the independent effects of the individual chemicals in the mixture, prenatal PFHxS was negatively associated with HDL-C and prenatal PFNA was positively associated with WC and these were opposing directions from the overall mixture. Further, the network consisted of five distinct communities connected with positive and negative correlations. The selected inflammatory biomarkers were positively, while the postnatal PFAS were negatively related with the included cardiometabolic factors, and only prenatal PFOA was positively related with the pro-inflammatory cytokine IL-1beta and WC. Our study supports that prenatal, rather than postnatal, PFAS exposure might contribute to an unfavorable lipidemic profile and adiposity in childhood.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52260
http://dx.doi.org/10.1016/j.envint.2021.106853
url http://hdl.handle.net/10230/52260
http://dx.doi.org/10.1016/j.envint.2021.106853
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EC/FP7/308333
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
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spelling Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohortsPapadopoulou, Eleni, 1985-Basagaña Flores, XavierCasas Sanahuja, MaribelFossati, SerenaMaitre, LéaSabidó Aguadé, Eduard, 1981-Borràs, EvaUrquiza, José M.Vrijheid, MartineChatzi, LedaCor--MalaltiesInfants -- MalaltiesDeveloping children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is associated with poor metabolic health in children. We studied the association between prenatal and postnatal PFASs mixture exposure and cardiometabolic health in children, and the role of inflammatory proteins. In 1,101 mothers-child pairs from the Human Early Life Exposome project, we measured the concentrations of PFAS in blood collected in pregnancy and at 8 years (range = 6-12 years). We applied Bayesian Kernel Machine regression (BKMR) to estimate the associations between exposure to PFAS mixture and the cardiometabolic factors as age and sex- specific z-scores of waist circumference (WC), systolic and diastolic blood pressures (BP), and concentrations of triglycerides (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) cholesterol. We measured thirty six inflammatory biomarkers in child plasma and examined the underlying role of inflammatory status for the exposure-outcome association by integrating the three panels into a network. Exposure to the PFAS mixture was positively associated with HDL-C and systolic BP, and negatively associated with WC, LDL-C and TG. When we examined the independent effects of the individual chemicals in the mixture, prenatal PFHxS was negatively associated with HDL-C and prenatal PFNA was positively associated with WC and these were opposing directions from the overall mixture. Further, the network consisted of five distinct communities connected with positive and negative correlations. The selected inflammatory biomarkers were positively, while the postnatal PFAS were negatively related with the included cardiometabolic factors, and only prenatal PFOA was positively related with the pro-inflammatory cytokine IL-1beta and WC. Our study supports that prenatal, rather than postnatal, PFAS exposure might contribute to an unfavorable lipidemic profile and adiposity in childhood.This work was supported by the Norwegian Research Council under the MILJØFORSK-Miljøforskning for en grønn samfunnsomstilling call (project No. 268465-short name: "CATCHUP project"). The HELIX project is funded by the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308,333 – the HELIX project. The HELIX program is built on six existing cohorts that received previous funding. The Born in Bradford (BiB) study presents independent research commissioned by the National Institute for Health Research Collaboration for Applied Health Research and Care (NIHR CLAHRC) and the Programme Grants for Applied Research funding scheme (RP-PG-0407–10044). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6–04-2014_31V-66). Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Dr. Leda Chatzi was supported by NIH/NIHES R01 ES029944, R01ES030691, R01ES030364, R21 ES029681, R21 ES028903, and P30 ES007048-23. Dr. David Conti was supported by P01CA196569, R01CA140561, R01 ES016813, R01 ES029944, R01ES030691, R01ES030364. Dr. Nikos Stratakis was supported by NIH/NIHES R21 ES029681 and P30 ES007048-23, and NIH/NIDDK P30 DK048522-24. The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D + i 2013–2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. ISGlobal affiliated researchers acknowledge support from the Spanish Ministry of Science, Innovation and Universities, “Centro de Excelencia Severo Ochoa 2013–2017”, SEV-2012–0208, and “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595)Elsevier202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52260http://dx.doi.org/10.1016/j.envint.2021.106853reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésinfo:eu-repo/grantAgreement/EC/FP7/308333© 2021 Eleni Papadopoulou et al . Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/522602026-06-12T07:21:37Z
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