Disrupted principal network organisation in multiple sclerosis relates to disability

Structural network-based approaches can assess white matter connections revealing topological alterations in multiple sclerosis (MS). However, principal network (PN) organisation and its clinical relevance in MS has not been explored yet. Here, structural networks were reconstructed from diffusion d...

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Autores: Charalambous, Thalis, Clayden, Jonathan D., Powell, Elizabeth, Prados Carrasco, Ferran, TUR, CARMEN, Kanber, Baris, Chard, Declan, Ourselin, Sebastien, Gandini Wheeler-Kingshott, Claudia A.M., Thompson, Alan, Toosy, Ahmed
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/122586
Acceso en línea:https://hdl.handle.net/10609/122586
Access Level:acceso abierto
Palabra clave:multiple sclerosis
disability
neural networks
esclerosis múltiple
discapacidad
redes neuronales
esclerosi múltiple
discapacitat
xarxes neuronals
Multiple sclerosis
Esclerosi múltiple
Esclerosis múltiple
id ES_6eb19e7dfd6ed672c3148d770313c9fd
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Disrupted principal network organisation in multiple sclerosis relates to disabilityCharalambous, ThalisClayden, Jonathan D.Powell, ElizabethPrados Carrasco, FerranTUR, CARMENKanber, BarisChard, DeclanOurselin, SebastienGandini Wheeler-Kingshott, Claudia A.M.Thompson, AlanToosy, Ahmedmultiple sclerosisdisabilityneural networksesclerosis múltiplediscapacidadredes neuronalesesclerosi múltiplediscapacitatxarxes neuronalsMultiple sclerosisEsclerosi múltipleEsclerosis múltipleStructural network-based approaches can assess white matter connections revealing topological alterations in multiple sclerosis (MS). However, principal network (PN) organisation and its clinical relevance in MS has not been explored yet. Here, structural networks were reconstructed from diffusion data in 58 relapsing-remitting MS (RRMS), 28 primary progressive MS (PPMS), 36 secondary progressive (SPMS) and 51 healthy controls (HCs). Network hubs' strengths were compared with HCs. Then, PN analysis was performed in each clinical subtype. Regression analysis was applied to investigate the associations between nodal strength derived from the first and second PNs (PN1 and PN2) in MS, with clinical disability. Compared with HCs, MS patients had preserved hub number, but some hubs exhibited reduced strength. PN1 comprised 10 hubs in HCs, RRMS and PPMS but did not include the right thalamus in SPMS. PN2 comprised 10 hub regions with intra-hemispheric connections in HCs. In MS, this subnetwork did not include the right putamen whilst in SPMS the right thalamus was also not included. Decreased nodal strength of the right thalamus and putamen from the PNs correlated strongly with higher clinical disability. These PN analyses suggest distinct patterns of disruptions in MS subtypes which are clinically relevant.Scientific ReportsUniversity College London (UCL)Università degli Studi di PaviaCasimiro Mondino National Institute of NeurologyUniversitat Oberta de Catalunya (UOC)202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/10609/122586reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésScientific Reports, 2020, 10()https://www.nature.com/articles/s41598-020-60611-4info:eu-repo/grantAgreement/EP/H046410/1info:eu-repo/grantAgreement/EP/J020990/1info:eu-repo/grantAgreement/EP/K005278/info:eu-repo/grantAgreement/MR/J01107X/1info:eu-repo/grantAgreement/MR/S026088/1CC BYhttp://creativecommons.org/licenses/by/4.0/es/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1225862026-05-28T12:42:01Z
dc.title.none.fl_str_mv Disrupted principal network organisation in multiple sclerosis relates to disability
title Disrupted principal network organisation in multiple sclerosis relates to disability
spellingShingle Disrupted principal network organisation in multiple sclerosis relates to disability
Charalambous, Thalis
multiple sclerosis
disability
neural networks
esclerosis múltiple
discapacidad
redes neuronales
esclerosi múltiple
discapacitat
xarxes neuronals
Multiple sclerosis
Esclerosi múltiple
Esclerosis múltiple
title_short Disrupted principal network organisation in multiple sclerosis relates to disability
title_full Disrupted principal network organisation in multiple sclerosis relates to disability
title_fullStr Disrupted principal network organisation in multiple sclerosis relates to disability
title_full_unstemmed Disrupted principal network organisation in multiple sclerosis relates to disability
title_sort Disrupted principal network organisation in multiple sclerosis relates to disability
dc.creator.none.fl_str_mv Charalambous, Thalis
Clayden, Jonathan D.
Powell, Elizabeth
Prados Carrasco, Ferran
TUR, CARMEN
Kanber, Baris
Chard, Declan
Ourselin, Sebastien
Gandini Wheeler-Kingshott, Claudia A.M.
Thompson, Alan
Toosy, Ahmed
author Charalambous, Thalis
author_facet Charalambous, Thalis
Clayden, Jonathan D.
Powell, Elizabeth
Prados Carrasco, Ferran
TUR, CARMEN
Kanber, Baris
Chard, Declan
Ourselin, Sebastien
Gandini Wheeler-Kingshott, Claudia A.M.
Thompson, Alan
Toosy, Ahmed
author_role author
author2 Clayden, Jonathan D.
Powell, Elizabeth
Prados Carrasco, Ferran
TUR, CARMEN
Kanber, Baris
Chard, Declan
Ourselin, Sebastien
Gandini Wheeler-Kingshott, Claudia A.M.
Thompson, Alan
Toosy, Ahmed
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University College London (UCL)
Università degli Studi di Pavia
Casimiro Mondino National Institute of Neurology
Universitat Oberta de Catalunya (UOC)
dc.subject.none.fl_str_mv multiple sclerosis
disability
neural networks
esclerosis múltiple
discapacidad
redes neuronales
esclerosi múltiple
discapacitat
xarxes neuronals
Multiple sclerosis
Esclerosi múltiple
Esclerosis múltiple
topic multiple sclerosis
disability
neural networks
esclerosis múltiple
discapacidad
redes neuronales
esclerosi múltiple
discapacitat
xarxes neuronals
Multiple sclerosis
Esclerosi múltiple
Esclerosis múltiple
description Structural network-based approaches can assess white matter connections revealing topological alterations in multiple sclerosis (MS). However, principal network (PN) organisation and its clinical relevance in MS has not been explored yet. Here, structural networks were reconstructed from diffusion data in 58 relapsing-remitting MS (RRMS), 28 primary progressive MS (PPMS), 36 secondary progressive (SPMS) and 51 healthy controls (HCs). Network hubs' strengths were compared with HCs. Then, PN analysis was performed in each clinical subtype. Regression analysis was applied to investigate the associations between nodal strength derived from the first and second PNs (PN1 and PN2) in MS, with clinical disability. Compared with HCs, MS patients had preserved hub number, but some hubs exhibited reduced strength. PN1 comprised 10 hubs in HCs, RRMS and PPMS but did not include the right thalamus in SPMS. PN2 comprised 10 hub regions with intra-hemispheric connections in HCs. In MS, this subnetwork did not include the right putamen whilst in SPMS the right thalamus was also not included. Decreased nodal strength of the right thalamus and putamen from the PNs correlated strongly with higher clinical disability. These PN analyses suggest distinct patterns of disruptions in MS subtypes which are clinically relevant.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10609/122586
url https://hdl.handle.net/10609/122586
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports, 2020, 10()
https://www.nature.com/articles/s41598-020-60611-4
info:eu-repo/grantAgreement/EP/H046410/1
info:eu-repo/grantAgreement/EP/J020990/1
info:eu-repo/grantAgreement/EP/K005278/
info:eu-repo/grantAgreement/MR/J01107X/1
info:eu-repo/grantAgreement/MR/S026088/1
dc.rights.none.fl_str_mv CC BY
http://creativecommons.org/licenses/by/4.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY
http://creativecommons.org/licenses/by/4.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Scientific Reports
publisher.none.fl_str_mv Scientific Reports
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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