High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing

In recent years, metaplasmonic biosensors have emerged as a novel counterpart of well-established plasmonic biosensors based on thin metallic layers. Metaplasmonic biosensors offer high potential for sensor miniaturiza-tion, extreme sensitivity biosensing, and high multiplexing capabilities with det...

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Detalles Bibliográficos
Autores: Ugarte Orozco, Maria J., López Muñoz, Gerardo A., Antonio Pérez, Aurora, Esquivel Ortiz, Karla M., Ramon Azcon, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/198370
Acceso en línea:https://hdl.handle.net/2445/198370
Access Level:acceso abierto
Palabra clave:Biosensors
Interfícies biològiques
Cultiu cel·lular
Biological interfaces
Cell culture
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spelling High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensingUgarte Orozco, Maria J.López Muñoz, Gerardo A.Antonio Pérez, AuroraEsquivel Ortiz, Karla M.Ramon Azcon, JavierBiosensorsInterfícies biològiquesCultiu cel·lularBiosensorsBiological interfacesCell cultureIn recent years, metaplasmonic biosensors have emerged as a novel counterpart of well-established plasmonic biosensors based on thin metallic layers. Metaplasmonic biosensors offer high potential for sensor miniaturiza-tion, extreme sensitivity biosensing, and high multiplexing capabilities with detection methods free of coupling optical elements. These capabilities make metaplasmonic biosensors highly attractive for Point-of-Care and handled/portable devices or novel On-Chip devices; as a result, it has increased the number of prototypes and potential applications that emerged during the last years. One of the main challenges to achieving fully operative devices is the achievement of high-throughput biointerfaces for sensitive and selective biodetection in complex media. Despite the superior surface sensitivity achieved by metaplasmonic sensors compared to conventional plasmonic sensors based on metallic thin films, the main limitations to achieving high-throughput and multiplexed biosensing usually are associated with the sensitivity and selectivity of the bioin-terface and, as a consequence, their application to the direct analysis of real complex samples. This graphical review discusses the potential challenges and capabilities of different biofunctionalization strategies, biorecog-nition elements, and antifouling strategies to achieve scalable and high-throughput metaplasmonic biosensing for Point-of-Care devices and bioengineering applications like Organs-On-Chip.2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/198370Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.crbiot.2023.100119Current Research In Biotechnology, 2023, vol. 5, num. 100119https://doi.org/10.1016/j.crbiot.2023.100119cc by-nc-nd (c) Ugarte Orozco, Maria J. et al., 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1983702026-05-27T06:46:51Z
dc.title.none.fl_str_mv High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
title High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
spellingShingle High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
Ugarte Orozco, Maria J.
Biosensors
Interfícies biològiques
Cultiu cel·lular
Biosensors
Biological interfaces
Cell culture
title_short High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
title_full High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
title_fullStr High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
title_full_unstemmed High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
title_sort High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing
dc.creator.none.fl_str_mv Ugarte Orozco, Maria J.
López Muñoz, Gerardo A.
Antonio Pérez, Aurora
Esquivel Ortiz, Karla M.
Ramon Azcon, Javier
author Ugarte Orozco, Maria J.
author_facet Ugarte Orozco, Maria J.
López Muñoz, Gerardo A.
Antonio Pérez, Aurora
Esquivel Ortiz, Karla M.
Ramon Azcon, Javier
author_role author
author2 López Muñoz, Gerardo A.
Antonio Pérez, Aurora
Esquivel Ortiz, Karla M.
Ramon Azcon, Javier
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biosensors
Interfícies biològiques
Cultiu cel·lular
Biosensors
Biological interfaces
Cell culture
topic Biosensors
Interfícies biològiques
Cultiu cel·lular
Biosensors
Biological interfaces
Cell culture
description In recent years, metaplasmonic biosensors have emerged as a novel counterpart of well-established plasmonic biosensors based on thin metallic layers. Metaplasmonic biosensors offer high potential for sensor miniaturiza-tion, extreme sensitivity biosensing, and high multiplexing capabilities with detection methods free of coupling optical elements. These capabilities make metaplasmonic biosensors highly attractive for Point-of-Care and handled/portable devices or novel On-Chip devices; as a result, it has increased the number of prototypes and potential applications that emerged during the last years. One of the main challenges to achieving fully operative devices is the achievement of high-throughput biointerfaces for sensitive and selective biodetection in complex media. Despite the superior surface sensitivity achieved by metaplasmonic sensors compared to conventional plasmonic sensors based on metallic thin films, the main limitations to achieving high-throughput and multiplexed biosensing usually are associated with the sensitivity and selectivity of the bioin-terface and, as a consequence, their application to the direct analysis of real complex samples. This graphical review discusses the potential challenges and capabilities of different biofunctionalization strategies, biorecog-nition elements, and antifouling strategies to achieve scalable and high-throughput metaplasmonic biosensing for Point-of-Care devices and bioengineering applications like Organs-On-Chip.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/198370
url https://hdl.handle.net/2445/198370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.crbiot.2023.100119
Current Research In Biotechnology, 2023, vol. 5, num. 100119
https://doi.org/10.1016/j.crbiot.2023.100119
dc.rights.none.fl_str_mv cc by-nc-nd (c) Ugarte Orozco, Maria J. et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Ugarte Orozco, Maria J. et al., 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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