Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis
Rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) are the most common rheumatic diseases (RDs). They are characterised by chronic inflammation of the joints and musculoskeletal components. Adipose tissue releases adipokines that regulate numerous biological processes, including inflammat...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/736040 |
| Acceso en línea: | https://hdl.handle.net/10486/736040 https://dx.doi.org/10.3389/fimmu.2025.1636158 |
| Access Level: | acceso abierto |
| Palabra clave: | adipokines adipsin obesity rheumatic disease rheumatoid arthritis Medicina |
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Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritisNovella-Navarro, MartaGonzález Sánchez, LauraHernández-Breijo, BorjaPérez De Diego, RebecaSánchez-Corral, PilarLópez Trascasa, MargaritaMiranda-Carús, Maria-EugeniaVillalba, AlejandroBalsa, AlejandroMiguel Mendieta, Eugenio dePlasencia-Rodríguez, ChamaidaCorvillo, Fernandoadipokinesadipsinobesityrheumatic diseaserheumatoid arthritisMedicinaRheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) are the most common rheumatic diseases (RDs). They are characterised by chronic inflammation of the joints and musculoskeletal components. Adipose tissue releases adipokines that regulate numerous biological processes, including inflammation, thus stabilising the relationship between RDs and adipokines, such as adiponectin and leptin. The correlation between these adipokines and RA highlights a possible role of other adipokines in RDs. Therefore, we decided to analyse the role of the adipokine adipsin in the context of RDs. Adipsin levels were measured in serum from 233 patients (66 early-RA, 98 established-RA, and 69 axSpA) and 88 healthy controls (HCs). Associations between adipsin and clinical or demographic variables were assessed using univariate and multivariate regression models. The diagnostic utility of adipsin was evaluated using ROC curve analysis. Our study revealed that adipsin concentrations were significantly higher in both early-RA and established-RA patients than in axSpa and in HCs. No significant differences were found between axSpA and HCs. In early-RA, female sex and prednisone use were independently associated with higher adipsin levels. In established-RA, age and disease duration showed a positive association with adipsin concentrations. In axSpA, disease duration and CRP correlated with adipsin levels, but no consistent associations were observed for BMI or HLA-B27 status. ROC analysis revealed good discriminatory capacity of adipsin to differentiate early-RA from HCs (AUC = 0.82; optimal cut-off: 1.325 µg/mL). We provide evidence supporting the involvement of adipsin in the pathophysiology of RA and highlight its value as a new potential biomarkerThe author(s) declare that financial support was received for the research and/or publication of this article. This study was funded by the Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund of the European Union (grant PI15-00255) and by the Spanish Autonomous Region of Madrid (Complement III-CM network; P2022/BMD-7278). FC was awarded a research fellowship by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP), Fundación SENEFRO (http://www.senefro.org), and IdiPAZ (Beca Luis Álvarez)FrontiersFacultad de MedicinaDepartamento de MedicinaGobierno de EspañaInstituto de Salud Carlos IIIComunidad de Madrid20252025-08-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/736040https://dx.doi.org/10.3389/fimmu.2025.163615840842998reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7360402026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| title |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| spellingShingle |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis Novella-Navarro, Marta adipokines adipsin obesity rheumatic disease rheumatoid arthritis Medicina |
| title_short |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| title_full |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| title_fullStr |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| title_full_unstemmed |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| title_sort |
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis |
| dc.creator.none.fl_str_mv |
Novella-Navarro, Marta González Sánchez, Laura Hernández-Breijo, Borja Pérez De Diego, Rebeca Sánchez-Corral, Pilar López Trascasa, Margarita Miranda-Carús, Maria-Eugenia Villalba, Alejandro Balsa, Alejandro Miguel Mendieta, Eugenio de Plasencia-Rodríguez, Chamaida Corvillo, Fernando |
| author |
Novella-Navarro, Marta |
| author_facet |
Novella-Navarro, Marta González Sánchez, Laura Hernández-Breijo, Borja Pérez De Diego, Rebeca Sánchez-Corral, Pilar López Trascasa, Margarita Miranda-Carús, Maria-Eugenia Villalba, Alejandro Balsa, Alejandro Miguel Mendieta, Eugenio de Plasencia-Rodríguez, Chamaida Corvillo, Fernando |
| author_role |
author |
| author2 |
González Sánchez, Laura Hernández-Breijo, Borja Pérez De Diego, Rebeca Sánchez-Corral, Pilar López Trascasa, Margarita Miranda-Carús, Maria-Eugenia Villalba, Alejandro Balsa, Alejandro Miguel Mendieta, Eugenio de Plasencia-Rodríguez, Chamaida Corvillo, Fernando |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Facultad de Medicina Departamento de Medicina Gobierno de España Instituto de Salud Carlos III Comunidad de Madrid |
| dc.subject.none.fl_str_mv |
adipokines adipsin obesity rheumatic disease rheumatoid arthritis Medicina |
| topic |
adipokines adipsin obesity rheumatic disease rheumatoid arthritis Medicina |
| description |
Rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) are the most common rheumatic diseases (RDs). They are characterised by chronic inflammation of the joints and musculoskeletal components. Adipose tissue releases adipokines that regulate numerous biological processes, including inflammation, thus stabilising the relationship between RDs and adipokines, such as adiponectin and leptin. The correlation between these adipokines and RA highlights a possible role of other adipokines in RDs. Therefore, we decided to analyse the role of the adipokine adipsin in the context of RDs. Adipsin levels were measured in serum from 233 patients (66 early-RA, 98 established-RA, and 69 axSpA) and 88 healthy controls (HCs). Associations between adipsin and clinical or demographic variables were assessed using univariate and multivariate regression models. The diagnostic utility of adipsin was evaluated using ROC curve analysis. Our study revealed that adipsin concentrations were significantly higher in both early-RA and established-RA patients than in axSpa and in HCs. No significant differences were found between axSpA and HCs. In early-RA, female sex and prednisone use were independently associated with higher adipsin levels. In established-RA, age and disease duration showed a positive association with adipsin concentrations. In axSpA, disease duration and CRP correlated with adipsin levels, but no consistent associations were observed for BMI or HLA-B27 status. ROC analysis revealed good discriminatory capacity of adipsin to differentiate early-RA from HCs (AUC = 0.82; optimal cut-off: 1.325 µg/mL). We provide evidence supporting the involvement of adipsin in the pathophysiology of RA and highlight its value as a new potential biomarker |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025-08-06 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10486/736040 https://dx.doi.org/10.3389/fimmu.2025.1636158 40842998 |
| url |
https://hdl.handle.net/10486/736040 https://dx.doi.org/10.3389/fimmu.2025.1636158 |
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40842998 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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Universidad Autónoma de Madrid |
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