Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine

In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significan...

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Detalhes bibliográficos
Autores: Santos, Lúcia Helena, Maulvault, Ana Luísa, Jaén Gil, Adrián, Marques, António, Barceló i Cullerés, Damià, Rodríguez Mozaz, Sara
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/22427
Acesso em linha:http://hdl.handle.net/10256/22427
Access Level:Acceso aberto
Palavra-chave:Toxicologia ambiental
Environmental toxicology
Contaminants emergents en l'aigua
Emerging contaminants in water
Peixos -- Efecte de la contaminació de l'aigua
Fishes -- Effect of water pollution on
Peixos -- Efecte dels productes químics
Fishes -- Effect of chemicals on
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spelling Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxineSantos, Lúcia HelenaMaulvault, Ana LuísaJaén Gil, AdriánMarques, AntónioBarceló i Cullerés, DamiàRodríguez Mozaz, SaraToxicologia ambientalEnvironmental toxicologyContaminants emergents en l'aiguaEmerging contaminants in waterPeixos -- Efecte de la contaminació de l'aiguaFishes -- Effect of water pollution onPeixos -- Efecte dels productes químicsFishes -- Effect of chemicals onIn this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levelsThis work was funded by the 7th EU-FP (ECsafeSEAFOOD project; GA n° 311820) and the European Regional Development Fund (FEDER) and by Spanish Ministry of Economy and Competitiveness (PGE-2010). Lúcia H.M.L.M. Santos thanks the Juan de la Cierva program (IJCI-2017-32747) from the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities (AEI-MCIU).Elsevierinfo2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/22427© Environmental Toxicology and Pharmacology, 2023, vol. 98, art.núm. 104063Articles publicats (ICRA)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2023.104063info:eu-repo/semantics/altIdentifier/issn/1382-6689info:eu-repo/semantics/altIdentifier/eissn/1872-7077Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/224272026-05-29T05:05:01Z
dc.title.none.fl_str_mv Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
title Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
spellingShingle Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
Santos, Lúcia Helena
Toxicologia ambiental
Environmental toxicology
Contaminants emergents en l'aigua
Emerging contaminants in water
Peixos -- Efecte de la contaminació de l'aigua
Fishes -- Effect of water pollution on
Peixos -- Efecte dels productes químics
Fishes -- Effect of chemicals on
title_short Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
title_full Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
title_fullStr Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
title_full_unstemmed Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
title_sort Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
dc.creator.none.fl_str_mv Santos, Lúcia Helena
Maulvault, Ana Luísa
Jaén Gil, Adrián
Marques, António
Barceló i Cullerés, Damià
Rodríguez Mozaz, Sara
author Santos, Lúcia Helena
author_facet Santos, Lúcia Helena
Maulvault, Ana Luísa
Jaén Gil, Adrián
Marques, António
Barceló i Cullerés, Damià
Rodríguez Mozaz, Sara
author_role author
author2 Maulvault, Ana Luísa
Jaén Gil, Adrián
Marques, António
Barceló i Cullerés, Damià
Rodríguez Mozaz, Sara
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Toxicologia ambiental
Environmental toxicology
Contaminants emergents en l'aigua
Emerging contaminants in water
Peixos -- Efecte de la contaminació de l'aigua
Fishes -- Effect of water pollution on
Peixos -- Efecte dels productes químics
Fishes -- Effect of chemicals on
topic Toxicologia ambiental
Environmental toxicology
Contaminants emergents en l'aigua
Emerging contaminants in water
Peixos -- Efecte de la contaminació de l'aigua
Fishes -- Effect of water pollution on
Peixos -- Efecte dels productes químics
Fishes -- Effect of chemicals on
description In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levels
publishDate 2023
dc.date.none.fl_str_mv 2023
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
peer-reviewed
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/22427
url http://hdl.handle.net/10256/22427
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2023.104063
info:eu-repo/semantics/altIdentifier/issn/1382-6689
info:eu-repo/semantics/altIdentifier/eissn/1872-7077
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv © Environmental Toxicology and Pharmacology, 2023, vol. 98, art.núm. 104063
Articles publicats (ICRA)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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