CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases

CD200 is a glycoprotein that binds with its receptor CD200R, providing immunosuppressive signals to T and NK cells. CD200 is expressed by normal stem cells and progenitors committed to B-lymphopoiesis and myeloid development. CD200 biological relevance in acute leukemias is only partially understood...

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Autores: González Guerrero, Laura, Castellet Farrus, Helena, Martínez Valverde, Clara, González Álvarez, Nuria, Guijarro Tomàs, Francisca, Lloveras, Natàlia, Pratcorona, Marta, Gich, Ignasi, Berenguer Molins, Pau, Perera Bel, Júlia, Zamora, Lurdes, Mascaró, Martí, Sampol, Antonia, García Guiñón, Antoni, Vives, Susana, Tormo, Mar, Arnan, Montserrat, Villamor i Casas, Neus, Nomdedéu, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/222099
Acceso en línea:https://hdl.handle.net/2445/222099
Access Level:acceso abierto
Palabra clave:Glicoproteïnes
Leucèmia mieloide
Glycoproteins
Myeloid leukemia
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spelling CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated casesGonzález Guerrero, LauraCastellet Farrus, HelenaMartínez Valverde, ClaraGonzález Álvarez, NuriaGuijarro Tomàs, FranciscaLloveras, NatàliaPratcorona, MartaGich, IgnasiBerenguer Molins, PauPerera Bel, JúliaZamora, LurdesMascaró, MartíSampol, AntoniaGarcía Guiñón, AntoniVives, SusanaTormo, MarArnan, MontserratVillamor i Casas, NeusNomdedéu, JosepGlicoproteïnesLeucèmia mieloideGlycoproteinsMyeloid leukemiaCD200 is a glycoprotein that binds with its receptor CD200R, providing immunosuppressive signals to T and NK cells. CD200 is expressed by normal stem cells and progenitors committed to B-lymphopoiesis and myeloid development. CD200 biological relevance in acute leukemias is only partially understood.The study included a consecutive series of four hundred thirty-one patients with acute myeloid leukemia (AML). Immunophenotype was established by multiparametric flow cytometry, and the genetic diagnosis was performed by PCR-based methods and a targeted resequencing method covering 42 genes.66% of AML patients expressed CD200 being significantly associated with CD34 reactivity. The frequency of CD200 positivity was higher in cases with core-binding factor genetic lesions such as RUNX1-RUNX1T1 (81.3%) fusions and CBFB-MHY11 (63.2%) rearrangements and also with biallelic CEBPA mutations (100%). The molecular AML group with the lowest CD200 reactivity (19.1%) corresponded to AML with NPM1 mutations. RNA seq showed no uniform pattern of infiltrating cells in CEBPA mutated AML. Deconvolution analysis may be used to assess the immunoregulatory mechanisms of AML.CD200 expression could help identify the more immature compartment and, combined with other markers, single out CEPA-mutated AML.Springer Science and Business Media LLC2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/222099Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13000-025-01655-wDiagnostic Pathology, 2025, vol. 20, 56https://doi.org/10.1186/s13000-025-01655-wcc-by-nc-nd (c) González Guerrero, Laura et al., 2025http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2220992026-05-29T05:05:01Z
dc.title.none.fl_str_mv CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
title CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
spellingShingle CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
González Guerrero, Laura
Glicoproteïnes
Leucèmia mieloide
Glycoproteins
Myeloid leukemia
title_short CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
title_full CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
title_fullStr CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
title_full_unstemmed CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
title_sort CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases
dc.creator.none.fl_str_mv González Guerrero, Laura
Castellet Farrus, Helena
Martínez Valverde, Clara
González Álvarez, Nuria
Guijarro Tomàs, Francisca
Lloveras, Natàlia
Pratcorona, Marta
Gich, Ignasi
Berenguer Molins, Pau
Perera Bel, Júlia
Zamora, Lurdes
Mascaró, Martí
Sampol, Antonia
García Guiñón, Antoni
Vives, Susana
Tormo, Mar
Arnan, Montserrat
Villamor i Casas, Neus
Nomdedéu, Josep
author González Guerrero, Laura
author_facet González Guerrero, Laura
Castellet Farrus, Helena
Martínez Valverde, Clara
González Álvarez, Nuria
Guijarro Tomàs, Francisca
Lloveras, Natàlia
Pratcorona, Marta
Gich, Ignasi
Berenguer Molins, Pau
Perera Bel, Júlia
Zamora, Lurdes
Mascaró, Martí
Sampol, Antonia
García Guiñón, Antoni
Vives, Susana
Tormo, Mar
Arnan, Montserrat
Villamor i Casas, Neus
Nomdedéu, Josep
author_role author
author2 Castellet Farrus, Helena
Martínez Valverde, Clara
González Álvarez, Nuria
Guijarro Tomàs, Francisca
Lloveras, Natàlia
Pratcorona, Marta
Gich, Ignasi
Berenguer Molins, Pau
Perera Bel, Júlia
Zamora, Lurdes
Mascaró, Martí
Sampol, Antonia
García Guiñón, Antoni
Vives, Susana
Tormo, Mar
Arnan, Montserrat
Villamor i Casas, Neus
Nomdedéu, Josep
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Glicoproteïnes
Leucèmia mieloide
Glycoproteins
Myeloid leukemia
topic Glicoproteïnes
Leucèmia mieloide
Glycoproteins
Myeloid leukemia
description CD200 is a glycoprotein that binds with its receptor CD200R, providing immunosuppressive signals to T and NK cells. CD200 is expressed by normal stem cells and progenitors committed to B-lymphopoiesis and myeloid development. CD200 biological relevance in acute leukemias is only partially understood.The study included a consecutive series of four hundred thirty-one patients with acute myeloid leukemia (AML). Immunophenotype was established by multiparametric flow cytometry, and the genetic diagnosis was performed by PCR-based methods and a targeted resequencing method covering 42 genes.66% of AML patients expressed CD200 being significantly associated with CD34 reactivity. The frequency of CD200 positivity was higher in cases with core-binding factor genetic lesions such as RUNX1-RUNX1T1 (81.3%) fusions and CBFB-MHY11 (63.2%) rearrangements and also with biallelic CEBPA mutations (100%). The molecular AML group with the lowest CD200 reactivity (19.1%) corresponded to AML with NPM1 mutations. RNA seq showed no uniform pattern of infiltrating cells in CEBPA mutated AML. Deconvolution analysis may be used to assess the immunoregulatory mechanisms of AML.CD200 expression could help identify the more immature compartment and, combined with other markers, single out CEPA-mutated AML.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222099
url https://hdl.handle.net/2445/222099
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13000-025-01655-w
Diagnostic Pathology, 2025, vol. 20, 56
https://doi.org/10.1186/s13000-025-01655-w
dc.rights.none.fl_str_mv cc-by-nc-nd (c) González Guerrero, Laura et al., 2025
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) González Guerrero, Laura et al., 2025
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410429196828672
score 15,811543

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