Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk

[EN] A large number of nutrients and bioactive ingredients found in milk play an important role in the nourishment of breast-fed infants and dairy consumers. Some of these ingredients include physiologically relevant compounds such as vitamins, peptides, neuroactive compounds and hormones. Conversel...

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Autores: García Lino, Alba María, Álvarez Fernández, Indira, Blanco Paniagua, Esther, Merino Peláez, Gracia, Álvarez de Felipe, Ana Isabel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Ajuntament de Barcelona
Repositório:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/17413
Acesso em linha:https://hdl.handle.net/10612/17413
Access Level:Acceso aberto
Palavra-chave:Fisiología
ABC-transporters
Lactation
Mammary gland
Milk
SLC-transporters
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spelling Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into MilkGarcía Lino, Alba MaríaÁlvarez Fernández, IndiraBlanco Paniagua, EstherMerino Peláez, GraciaÁlvarez de Felipe, Ana IsabelFisiologíaABC-transportersLactationMammary glandMilkSLC-transporters[EN] A large number of nutrients and bioactive ingredients found in milk play an important role in the nourishment of breast-fed infants and dairy consumers. Some of these ingredients include physiologically relevant compounds such as vitamins, peptides, neuroactive compounds and hormones. Conversely, milk may contain substances—drugs, pesticides, carcinogens, environmental pollutants—which have undesirable effects on health. The transfer of these compounds into milk is unavoidably linked to the function of transport proteins. Expression of transporters belonging to the ATP-binding cassette (ABC-) and Solute Carrier (SLC-) superfamilies varies with the lactation stages of the mammary gland. In particular, Organic Anion Transporting Polypeptides 1A2 (OATP1A2) and 2B1 (OATP2B1), Organic Cation Transporter 1 (OCT1), Novel Organic Cation Transporter 1 (OCTN1), Concentrative Nucleoside Transporters 1, 2 and 3 (CNT1, CNT2 and CNT3), Peptide Transporter 2 (PEPT2), Sodium-dependent Vitamin C Transporter 2 (SVCT2), Multidrug Resistance-associated Protein 5 (ABCC5) and Breast Cancer Resistance Protein (ABCG2) are highly induced during lactation. This review will focus on these transporters overexpressed during lactation and their role in the transfer of products into the milk, including both beneficial and harmful compounds. Furthermore, additional factors, such as regulation, polymorphisms or drug-drug interactions will be described.SIMDPIFisiologiaFacultad de Veterinaria2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://hdl.handle.net/10612/17413reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Ajuntament de BarcelonaIngléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/174132026-06-24T12:43:27Z
dc.title.none.fl_str_mv Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
title Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
spellingShingle Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
García Lino, Alba María
Fisiología
ABC-transporters
Lactation
Mammary gland
Milk
SLC-transporters
title_short Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
title_full Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
title_fullStr Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
title_full_unstemmed Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
title_sort Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk
dc.creator.none.fl_str_mv García Lino, Alba María
Álvarez Fernández, Indira
Blanco Paniagua, Esther
Merino Peláez, Gracia
Álvarez de Felipe, Ana Isabel
author García Lino, Alba María
author_facet García Lino, Alba María
Álvarez Fernández, Indira
Blanco Paniagua, Esther
Merino Peláez, Gracia
Álvarez de Felipe, Ana Isabel
author_role author
author2 Álvarez Fernández, Indira
Blanco Paniagua, Esther
Merino Peláez, Gracia
Álvarez de Felipe, Ana Isabel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fisiologia
Facultad de Veterinaria
dc.subject.none.fl_str_mv Fisiología
ABC-transporters
Lactation
Mammary gland
Milk
SLC-transporters
topic Fisiología
ABC-transporters
Lactation
Mammary gland
Milk
SLC-transporters
description [EN] A large number of nutrients and bioactive ingredients found in milk play an important role in the nourishment of breast-fed infants and dairy consumers. Some of these ingredients include physiologically relevant compounds such as vitamins, peptides, neuroactive compounds and hormones. Conversely, milk may contain substances—drugs, pesticides, carcinogens, environmental pollutants—which have undesirable effects on health. The transfer of these compounds into milk is unavoidably linked to the function of transport proteins. Expression of transporters belonging to the ATP-binding cassette (ABC-) and Solute Carrier (SLC-) superfamilies varies with the lactation stages of the mammary gland. In particular, Organic Anion Transporting Polypeptides 1A2 (OATP1A2) and 2B1 (OATP2B1), Organic Cation Transporter 1 (OCT1), Novel Organic Cation Transporter 1 (OCTN1), Concentrative Nucleoside Transporters 1, 2 and 3 (CNT1, CNT2 and CNT3), Peptide Transporter 2 (PEPT2), Sodium-dependent Vitamin C Transporter 2 (SVCT2), Multidrug Resistance-associated Protein 5 (ABCC5) and Breast Cancer Resistance Protein (ABCG2) are highly induced during lactation. This review will focus on these transporters overexpressed during lactation and their role in the transfer of products into the milk, including both beneficial and harmful compounds. Furthermore, additional factors, such as regulation, polymorphisms or drug-drug interactions will be described.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10612/17413
url https://hdl.handle.net/10612/17413
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Ajuntament de Barcelona
instname_str Ajuntament de Barcelona
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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