Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein

Abstract Hemagglutinin-esterases (HE) are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and/or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glyc...

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Autores: Pignatelli Garrigos, Jaime, Alonso-Padilla, Julio, Rodríguez, Dolores
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/94760
Acceso en línea:http://dx.doi.org/10.1186/1297-9716-44-126
http://hdl.handle.net/10261/94760
Access Level:acceso abierto
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spelling Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) proteinPignatelli Garrigos, JaimeAlonso-Padilla, JulioRodríguez, DoloresAbstract Hemagglutinin-esterases (HE) are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and/or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glycan residues in the enteric and respiratory tracts. The role of the HE protein during the torovirus infection cycle remains unknown, although it is believed to be important in the natural infection process. The phylogenetic analysis of HE coding sequences from porcine torovirus (PToV) field strains revealed the existence of two distinct HE lineages. In a previous study, PToV virus strains with HE proteins from the two lineages were found coexisting in a pig herd, and they were even obtained from the same animal at two consecutive sampling time points. In this work, we report antigenic differences between the two HE lineages, and discuss the possible implications that the coexistence of viruses belonging to both lineages might have on the spread and sustainment of PToV infection in the farms.This work was supported by grants AGL2010-15495 and CONSOLIDER-PORCIVIR CSD2006-00007 from the Spanish Ministry of Science and Innovation. Jaime Pignatelli and Julio Alonso-Padilla were both recipients of contracts financed with founding from the CONSOLIDER-PORCIVIR research project.Peer ReviewedBioMed Central2014201420132014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://dx.doi.org/10.1186/1297-9716-44-126http://hdl.handle.net/10261/94760reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCentro de Investigación en Sanidad Animal (CISA)info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/947602026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
title Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
spellingShingle Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
Pignatelli Garrigos, Jaime
title_short Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
title_full Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
title_fullStr Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
title_full_unstemmed Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
title_sort Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein
dc.creator.none.fl_str_mv Pignatelli Garrigos, Jaime
Alonso-Padilla, Julio
Rodríguez, Dolores
author Pignatelli Garrigos, Jaime
author_facet Pignatelli Garrigos, Jaime
Alonso-Padilla, Julio
Rodríguez, Dolores
author_role author
author2 Alonso-Padilla, Julio
Rodríguez, Dolores
author2_role author
author
description Abstract Hemagglutinin-esterases (HE) are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and/or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glycan residues in the enteric and respiratory tracts. The role of the HE protein during the torovirus infection cycle remains unknown, although it is believed to be important in the natural infection process. The phylogenetic analysis of HE coding sequences from porcine torovirus (PToV) field strains revealed the existence of two distinct HE lineages. In a previous study, PToV virus strains with HE proteins from the two lineages were found coexisting in a pig herd, and they were even obtained from the same animal at two consecutive sampling time points. In this work, we report antigenic differences between the two HE lineages, and discuss the possible implications that the coexistence of viruses belonging to both lineages might have on the spread and sustainment of PToV infection in the farms.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://dx.doi.org/10.1186/1297-9716-44-126
http://hdl.handle.net/10261/94760
url http://dx.doi.org/10.1186/1297-9716-44-126
http://hdl.handle.net/10261/94760
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Centro de Investigación en Sanidad Animal (CISA)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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