Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A...

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Detalles Bibliográficos
Autores: Martimianaki, G, Bertuccio, P, Alicandro, G, Pelucchi, C, Bravi, F, Carioli, G, Bonzi, R, Rabkin, CS, Liao, LM, Sinha, R, Johnson, K, Hu, JF, Palli, D, Ferraroni, M, Lunet, N, Morais, S, Tsugane, S, Hidaka, A, Hamada, GS, Lopez-Carrillo, L, Hernandez-Ramirez, RU, Zaridze, D, Maximovitch, D, Aragones, N, Martin, V, Ward, MH, Vioque, J, de la Hera, MG, Zhang, ZF, Kurtz, RC, Lagiou, P, Lagiou, A, Trichopoulou, A, Karakatsani, A, Malekzadeh, R, Camargo, MC, Curado, MP, Boccia, S, Boffetta, P, Negri, E, La Vecchia, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8150
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones8150
https://journals.lww.com/eurjcancerprev/Abstract/2022/03000/Coffee_consumption_and_gastric_cancer__a_pooled.2.aspx
Access Level:acceso abierto
Palabra clave:cardia cancer
case-control study
coffee
gastric cancer
pooled analysis
Descripción
Sumario:Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

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