Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom

Background Bloom-forming cyanobacteria occur globally in aquatic environments. They produce diverse bioactive metabolites, some of which are known to be toxic. The most studied cyanobacterial toxins are microcystins, anatoxin, and cylindrospermopsin, yet more than 2000 bioactive metabolites have bee...

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Autores: Filatova, Daria, Jones, Martin R., Núñez, Óscar, Farré, Marinella, Janssen, Elisabeth M.-L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/237029
Acceso en línea:http://hdl.handle.net/10261/237029
Access Level:acceso abierto
Palabra clave:Cyanotoxins
Surface water
Cyanopeptide
Mass spectrometry
Water quality
Natural toxin
Emerging contaminant
http://metadata.un.org/sdg/6
Ensure availability and sustainable management of water and sanitation for all
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spelling Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United KingdomFilatova, DariaJones, Martin R.Núñez, ÓscarFarré, MarinellaJanssen, Elisabeth M.-L.CyanotoxinsSurface waterCyanopeptideMass spectrometryWater qualityNatural toxinEmerging contaminanthttp://metadata.un.org/sdg/6Ensure availability and sustainable management of water and sanitation for allBackground Bloom-forming cyanobacteria occur globally in aquatic environments. They produce diverse bioactive metabolites, some of which are known to be toxic. The most studied cyanobacterial toxins are microcystins, anatoxin, and cylindrospermopsin, yet more than 2000 bioactive metabolites have been identified to date. Data on the occurrence of cyanopeptides other than microcystins in surface waters are sparse. Results We used a high-performance liquid chromatography–high-resolution tandem mass spectrometry/tandem mass spectrometry (HPLC–HRMS/MS) method to analyse cyanotoxin and cyanopeptide profiles in raw drinking water collected from three freshwater reservoirs in the United Kingdom. A total of 8 cyanopeptides were identified and quantified using reference standards. A further 20 cyanopeptides were identified based on a suspect-screening procedure, with class-equivalent quantification. Samples from Ingbirchworth reservoir showed the highest total cyanopeptide concentrations, reaching 5.8, 61, and 0.8 µg/L in August, September, and October, respectively. Several classes of cyanopeptides were identified with anabaenopeptins, cyanopeptolins, and microcystins dominating in September with 37%, 36%, and 26%, respectively. Samples from Tophill Low reservoir reached 2.4 µg/L in September, but remained below 0.2 µg/L in other months. Samples from Embsay reservoir did not exceed 0.1 µg/L. At Ingbirchworth and Tophill Low, the maximum chlorophyll-a concentrations of 37 µg/L and 22 µg/L, respectively, and cyanobacterial count of 6 × 104 cells/mL were observed at, or a few days after, peak cyanopeptide concentrations. These values exceed the World Health Organization’s guideline levels for relatively low probability of adverse health effects, which are defined as 10 µg/L chlorophyll-a and 2 × 104 cells/mL. Conclusions This data is the first to present concentrations of anabaenopeptins, cyanopeptolins, aeruginosins, and microginins, along with microcystins, in U.K. reservoirs. A better understanding of those cyanopeptides that are abundant in drinking water reservoirs can inform future monitoring and studies on abatement efficiency during water treatment.This study has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 722493.Peer reviewedSpringer NatureEuropean CommissionFarrè, Marinella [0000-0001-8391-6257]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/237029reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/722493https://doi.org/10.1186/s12302-021-00472-4Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2370292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
title Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
spellingShingle Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
Filatova, Daria
Cyanotoxins
Surface water
Cyanopeptide
Mass spectrometry
Water quality
Natural toxin
Emerging contaminant
http://metadata.un.org/sdg/6
Ensure availability and sustainable management of water and sanitation for all
title_short Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
title_full Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
title_fullStr Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
title_full_unstemmed Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
title_sort Cyanobacteria and their secondary metabolites in three freshwater reservoirs in the United Kingdom
dc.creator.none.fl_str_mv Filatova, Daria
Jones, Martin R.
Núñez, Óscar
Farré, Marinella
Janssen, Elisabeth M.-L.
author Filatova, Daria
author_facet Filatova, Daria
Jones, Martin R.
Núñez, Óscar
Farré, Marinella
Janssen, Elisabeth M.-L.
author_role author
author2 Jones, Martin R.
Núñez, Óscar
Farré, Marinella
Janssen, Elisabeth M.-L.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Farrè, Marinella [0000-0001-8391-6257]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cyanotoxins
Surface water
Cyanopeptide
Mass spectrometry
Water quality
Natural toxin
Emerging contaminant
http://metadata.un.org/sdg/6
Ensure availability and sustainable management of water and sanitation for all
topic Cyanotoxins
Surface water
Cyanopeptide
Mass spectrometry
Water quality
Natural toxin
Emerging contaminant
http://metadata.un.org/sdg/6
Ensure availability and sustainable management of water and sanitation for all
description Background Bloom-forming cyanobacteria occur globally in aquatic environments. They produce diverse bioactive metabolites, some of which are known to be toxic. The most studied cyanobacterial toxins are microcystins, anatoxin, and cylindrospermopsin, yet more than 2000 bioactive metabolites have been identified to date. Data on the occurrence of cyanopeptides other than microcystins in surface waters are sparse. Results We used a high-performance liquid chromatography–high-resolution tandem mass spectrometry/tandem mass spectrometry (HPLC–HRMS/MS) method to analyse cyanotoxin and cyanopeptide profiles in raw drinking water collected from three freshwater reservoirs in the United Kingdom. A total of 8 cyanopeptides were identified and quantified using reference standards. A further 20 cyanopeptides were identified based on a suspect-screening procedure, with class-equivalent quantification. Samples from Ingbirchworth reservoir showed the highest total cyanopeptide concentrations, reaching 5.8, 61, and 0.8 µg/L in August, September, and October, respectively. Several classes of cyanopeptides were identified with anabaenopeptins, cyanopeptolins, and microcystins dominating in September with 37%, 36%, and 26%, respectively. Samples from Tophill Low reservoir reached 2.4 µg/L in September, but remained below 0.2 µg/L in other months. Samples from Embsay reservoir did not exceed 0.1 µg/L. At Ingbirchworth and Tophill Low, the maximum chlorophyll-a concentrations of 37 µg/L and 22 µg/L, respectively, and cyanobacterial count of 6 × 104 cells/mL were observed at, or a few days after, peak cyanopeptide concentrations. These values exceed the World Health Organization’s guideline levels for relatively low probability of adverse health effects, which are defined as 10 µg/L chlorophyll-a and 2 × 104 cells/mL. Conclusions This data is the first to present concentrations of anabaenopeptins, cyanopeptolins, aeruginosins, and microginins, along with microcystins, in U.K. reservoirs. A better understanding of those cyanopeptides that are abundant in drinking water reservoirs can inform future monitoring and studies on abatement efficiency during water treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/237029
url http://hdl.handle.net/10261/237029
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/722493
https://doi.org/10.1186/s12302-021-00472-4
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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