Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk

NTRODUCTION: Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent. METHODS: A wide coho...

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Bibliographic Details
Authors: Quintanilla Leo, Isabel, López-Cerón Pinilla, María, Jimeno, Mireya, Cuatrecasas Freixas, Miriam, Zabalza, Michel, Moreira Ruiz, Leticia, Alonso-Espinaco, Virginia, Rodríguez de Miguel, Cristina, Muñoz, Jenifer, Castellví Bel, Sergi, Llach Vila, Josep, Castells Garangou, Antoni, Balaguer Prunés, Francesc, Camps, Jordi, Pellisé Urquiza, Maria
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/165670
Online Access:https://hdl.handle.net/2445/165670
Access Level:Open access
Keyword:Càncer colorectal
Etiologia
Endoscòpia
Colorectal cancer
Etiology
Endoscopy
Description
Summary:NTRODUCTION: Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent. METHODS: A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features. RESULTS: We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a few APC and BRAF mutations and no microsatellite instability were detected in our samples. KRAS mutations were detected in 16.3% of ACF samples, which also exhibited increased MGMT hypermethylation. However, none of those events were found to be predictive of CRC risk. DISCUSSION: Although ACF might be preneoplastic lesions of the colon, they are not suitable biomarkers for assessing CRC progression.

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