Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance

This project was financially supported by the Joint Bilateral Project Japan-Spain (PCI2018-092997 to Rosalía Rodríguez-Rodríguez)/Agencia Estatal de Investigación (AEI) and by the Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033) (PID2020-114953RB-C22), and co-funded by the Europea...

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Detalles Bibliográficos
Autores: Rodriguez-Rodriguez, Rosalia, Fosch Masllovet, Anna, García-Chica, Jesús, Zagmutt, Sebastián, Casals, Nuria
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3558
Acceso en línea:http://hdl.handle.net/20.500.12328/3558
https://dx.doi.org/10.1111/jne.13234
Access Level:acceso abierto
Palabra clave:CPT1A
CPT1C
Hipotàlem
Metabolisme lipídic
Obesitat
Hipotálamo
Metabolismo de lípidos
Obesidad
Hypothalamus
Lipid metabolism
Obesity
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616.4
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repository_id_str
spelling Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balanceRodriguez-Rodriguez, RosaliaFosch Masllovet, AnnaGarcía-Chica, JesúsZagmutt, SebastiánCasals, NuriaCPT1ACPT1CHipotàlemMetabolisme lipídicObesitatCPT1ACPT1CHipotálamoMetabolismo de lípidosObesidadCPT1ACPT1CHypothalamusLipid metabolismObesity61616.4This project was financially supported by the Joint Bilateral Project Japan-Spain (PCI2018-092997 to Rosalía Rodríguez-Rodríguez)/Agencia Estatal de Investigación (AEI) and by the Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033) (PID2020-114953RB-C22), and co-funded by the European Regional Development Fund (ERDF) and the Biomedical Research Centre in Pathophysiology of Obesity and Nutrition (CIBEROBN) (grant CB06/03/0001). Figures were created with BioRender.comTackling the growing incidence and prevalence of obesity urgently requires uncovering new molecular pathways with therapeutic potential. The brain, and in particular the hypothalamus, is a major integrator of metabolic signals from peripheral tissues that regulate functions such as feeding behavior and energy expenditure. In obesity, hypothalamic capacity to sense nutritional status and regulate these functions is altered. An emerging line of research is that hypothalamic lipid metabolism plays a critical role in regulating energy balance. Here, we focus on the carnitine palmitoyltransferase 1 (CPT1) enzyme family responsible for long-chain fatty acid metabolism. The evidence suggests that two of its isoforms expressed in the brain, CPT1A and CPT1C, play a crucial role in hypothalamic lipid metabolism, and their promise as targets in food intake and bodyweight management is currently being intensively investigated. In this review we describe and discuss the metabolic actions and potential up- and downstream effectors of hypothalamic CPT1 isoforms, and posit the need to develop innovative nanomedicine platforms for selective targeting of CPT1 and related nutrient sensors in specific brain areas as potential next-generation therapy to treat obesity.info:eu-repo/semantics/publishedVersionJohn Wiley & Sons2023info:eu-repo/semantics/article9http://hdl.handle.net/20.500.12328/3558https://dx.doi.org/10.1111/jne.13234reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Neuroendocrinologyhttps://onlinelibrary.wiley.com/doi/full/10.1111/jne.13234info:eu-repo/grantAgreement/ES/MICINN/MCINinfo:eu-repo/grantAgreement/ES/MICINN/PID2020-114953RB-C2This is an open access article under the terms of theCreative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.© 2023 The Authors.Journal of Neuroendocrinologypublished by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/35582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
title Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
spellingShingle Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
Rodriguez-Rodriguez, Rosalia
CPT1A
CPT1C
Hipotàlem
Metabolisme lipídic
Obesitat
CPT1A
CPT1C
Hipotálamo
Metabolismo de lípidos
Obesidad
CPT1A
CPT1C
Hypothalamus
Lipid metabolism
Obesity
61
616.4
title_short Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
title_full Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
title_fullStr Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
title_full_unstemmed Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
title_sort Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: a promising strategy to regulate energy balance
dc.creator.none.fl_str_mv Rodriguez-Rodriguez, Rosalia
Fosch Masllovet, Anna
García-Chica, Jesús
Zagmutt, Sebastián
Casals, Nuria
author Rodriguez-Rodriguez, Rosalia
author_facet Rodriguez-Rodriguez, Rosalia
Fosch Masllovet, Anna
García-Chica, Jesús
Zagmutt, Sebastián
Casals, Nuria
author_role author
author2 Fosch Masllovet, Anna
García-Chica, Jesús
Zagmutt, Sebastián
Casals, Nuria
author2_role author
author
author
author
dc.subject.none.fl_str_mv CPT1A
CPT1C
Hipotàlem
Metabolisme lipídic
Obesitat
CPT1A
CPT1C
Hipotálamo
Metabolismo de lípidos
Obesidad
CPT1A
CPT1C
Hypothalamus
Lipid metabolism
Obesity
61
616.4
topic CPT1A
CPT1C
Hipotàlem
Metabolisme lipídic
Obesitat
CPT1A
CPT1C
Hipotálamo
Metabolismo de lípidos
Obesidad
CPT1A
CPT1C
Hypothalamus
Lipid metabolism
Obesity
61
616.4
description This project was financially supported by the Joint Bilateral Project Japan-Spain (PCI2018-092997 to Rosalía Rodríguez-Rodríguez)/Agencia Estatal de Investigación (AEI) and by the Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033) (PID2020-114953RB-C22), and co-funded by the European Regional Development Fund (ERDF) and the Biomedical Research Centre in Pathophysiology of Obesity and Nutrition (CIBEROBN) (grant CB06/03/0001). Figures were created with BioRender.com
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3558
https://dx.doi.org/10.1111/jne.13234
url http://hdl.handle.net/20.500.12328/3558
https://dx.doi.org/10.1111/jne.13234
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Neuroendocrinology
https://onlinelibrary.wiley.com/doi/full/10.1111/jne.13234
info:eu-repo/grantAgreement/ES/MICINN/MCIN
info:eu-repo/grantAgreement/ES/MICINN/PID2020-114953RB-C2
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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