Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort
Objective: To identify predictors of cardiovascular (CV) events in psoriatic arthritis (PsA) patients from the CARdiovascular in RheuMAtology (CARMA) project during 10 years of prospective follow-up. Methods: Between July 2010 and January 2012, 725 PsA patients were enrolled from 67 Spanish hospital...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/26596 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/26596 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardiovascular risk DAS28-ESR Disease activity PREVENT Psoriatic arthritis Urate |
| id |
ES_6de5aeb4a400b61f89a5ee1434430213 |
|---|---|
| oai_identifier_str |
oai:docusalut.com:20.500.13003/26596 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| title |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| spellingShingle |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort Llorca, Javier Cardiovascular risk DAS28-ESR Disease activity PREVENT Psoriatic arthritis Urate |
| title_short |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| title_full |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| title_fullStr |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| title_full_unstemmed |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| title_sort |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort |
| dc.creator.none.fl_str_mv |
Llorca, Javier Ferraz-Amaro, Iván Moreno-Martínez, María José Plaza, Zulema Sánchez-Alonso, Fernando Moreno-Ramos, Manuel José García-Gómez, Carmen Castañeda, Santos González-Juanatey, Carlos González-Gay, Miguel Ángel Sueiro, José L Fernández Pinto-Tasende, José A. de Rábago, Eugenia González Fernández, María J.González Codina, Ramón Huguet Yoldi, Beatriz Ramentol, Mercedes Marsal, Sara Ávila, Gabriela Alegre, Cayetano Steiner, Martina Cobo, Tatiana Muñoz, Santiago Gamero, Fernando Torón, José García Gil, María P.Moreno Mas, Antonio J. Espiño, Pilar Ros, Inmaculada Ibáñez-Barceló, Mónica Tornero, Jesús Piqueras, José A. Sanmartí, Raimon Berman, Horacio Patón, Oscar Fontseré Gutiérrez, Benjamín Fernández Abasolo, Lydia Salvador, José M.Pina Fábregas, María D. Romera, Montserrat Nolla, Joan M. Uriarte-Ecenarro, Miren Arias, Miriam García Vadillo, Jesús A.García de Vicuña, Rosario García Carmona, Eugenio Chamizo Nebro, Antonio Fernández. Ureña, Inmaculada Belmonte, María A. Irigoyen, María V. González, Olga Martínez Gómez, Rebeca Belmonte Bautista, Pastora Granados Sanz, Azucena Hernández Rey, José Santos González, Carmen O.Sánchez Bachiller, Javier Zea, Antonio Manero, Francisco J. Audera, Chesús Beltrán Medrano, Marta Pecondón, Ángela Erausquin, Celia Ojeda, Soledad Rodríguez-Lozano, Carlos BabíoHerraiz, Jesús Longo, Francisco J.López Monteagudo, Indalecio del Pino, Javier González, Ruth López Corrales, Alfonso Senabre, José M. Rosas, José C. Rotés, Isabel Moreno, Estefanía Erra, Alba Calvo, Javier Rueda, Amalia Möller, Ingrid Rodríguez, Isabel Barbadillo, Carmen Raya, Enrique Morales, Pilar Nieto, Ana Escribano, Ana Ruibal Gómez, Carmen García Expósito, Sergio Ros Nievas, Ginés Sánchez Navarro, Enrique Júdez Fernández, Manuela Sianes Pardo, Silvia Martínez Pujol, Manel GónzálezAlvarez, Beatriz Cantabrana, Alberto Bustabad, Sagrario Delgado, Esmeralda Muñoz, Alejandro Montero, Sergio Rodríguez Redondo, Javier Rivera Hernández, Teresa González Polo, Francisco J.González. Almagro, Raúl Menor Moreno, José M. Serret, Emilio Giner Méndez, Laura Cebrián Navío, María Teresa Peñalva, Teresa Pedraz Carballido, Cristina Fernández Pagán, Encarnación del Castillo, Pablo Mesa Naredo, Esperanza Cruz, Ana Turrión, Ana Gómez, Ana Pérez Sánchez, Julio Galindo, María Collantes, Eduardo Ruíz, Desireé Font, Pilar Bonilla, Gema Meseguer, Antonio López Moreno, Manuel J. Linares, Luis F. Morcillo, Mercedes Gómez, María L.González Aramburu, José M. Rivera, Natalia A. Berrizbeitia, Olaia Fernández. Park, HyeSang Riera, Manel León, Yolanda María Pérez-García, Carolina Maymó, Joan Amirall, Miriam Fiter, Jordi Melón, Julia Fernández Espadaler, Luis Belzunegui, Joaquín Bañegil, Inmaculada Díaz, César Valls, Ramón Castellví, Iván Bonet, María Alen, Jaime Calvo Sandoval, Trinidad Pérez Evrard, Eva Revuelta Godo, Javier R. Fernández, José Antonio González Miranda-Filloy, José A. |
| author |
Llorca, Javier |
| author_facet |
Llorca, Javier Ferraz-Amaro, Iván Moreno-Martínez, María José Plaza, Zulema Sánchez-Alonso, Fernando Moreno-Ramos, Manuel José García-Gómez, Carmen Castañeda, Santos González-Juanatey, Carlos González-Gay, Miguel Ángel Sueiro, José L Fernández Pinto-Tasende, José A. de Rábago, Eugenia González Fernández, María J.González Codina, Ramón Huguet Yoldi, Beatriz Ramentol, Mercedes Marsal, Sara Ávila, Gabriela Alegre, Cayetano Steiner, Martina Cobo, Tatiana Muñoz, Santiago Gamero, Fernando Torón, José García Gil, María P.Moreno Mas, Antonio J. Espiño, Pilar Ros, Inmaculada Ibáñez-Barceló, Mónica Tornero, Jesús Piqueras, José A. Sanmartí, Raimon Berman, Horacio Patón, Oscar Fontseré Gutiérrez, Benjamín Fernández Abasolo, Lydia Salvador, José M.Pina Fábregas, María D. Romera, Montserrat Nolla, Joan M. Uriarte-Ecenarro, Miren Arias, Miriam García Vadillo, Jesús A.García de Vicuña, Rosario García Carmona, Eugenio Chamizo Nebro, Antonio Fernández. Ureña, Inmaculada Belmonte, María A. Irigoyen, María V. González, Olga Martínez Gómez, Rebeca Belmonte Bautista, Pastora Granados Sanz, Azucena Hernández Rey, José Santos González, Carmen O.Sánchez Bachiller, Javier Zea, Antonio Manero, Francisco J. Audera, Chesús Beltrán Medrano, Marta Pecondón, Ángela Erausquin, Celia Ojeda, Soledad Rodríguez-Lozano, Carlos BabíoHerraiz, Jesús Longo, Francisco J.López Monteagudo, Indalecio del Pino, Javier González, Ruth López Corrales, Alfonso Senabre, José M. Rosas, José C. Rotés, Isabel Moreno, Estefanía Erra, Alba Calvo, Javier Rueda, Amalia Möller, Ingrid Rodríguez, Isabel Barbadillo, Carmen Raya, Enrique Morales, Pilar Nieto, Ana Escribano, Ana Ruibal Gómez, Carmen García Expósito, Sergio Ros Nievas, Ginés Sánchez Navarro, Enrique Júdez Fernández, Manuela Sianes Pardo, Silvia Martínez Pujol, Manel GónzálezAlvarez, Beatriz Cantabrana, Alberto Bustabad, Sagrario Delgado, Esmeralda Muñoz, Alejandro Montero, Sergio Rodríguez Redondo, Javier Rivera Hernández, Teresa González Polo, Francisco J.González. Almagro, Raúl Menor Moreno, José M. Serret, Emilio Giner Méndez, Laura Cebrián Navío, María Teresa Peñalva, Teresa Pedraz Carballido, Cristina Fernández Pagán, Encarnación del Castillo, Pablo Mesa Naredo, Esperanza Cruz, Ana Turrión, Ana Gómez, Ana Pérez Sánchez, Julio Galindo, María Collantes, Eduardo Ruíz, Desireé Font, Pilar Bonilla, Gema Meseguer, Antonio López Moreno, Manuel J. Linares, Luis F. Morcillo, Mercedes Gómez, María L.González Aramburu, José M. Rivera, Natalia A. Berrizbeitia, Olaia Fernández. Park, HyeSang Riera, Manel León, Yolanda María Pérez-García, Carolina Maymó, Joan Amirall, Miriam Fiter, Jordi Melón, Julia Fernández Espadaler, Luis Belzunegui, Joaquín Bañegil, Inmaculada Díaz, César Valls, Ramón Castellví, Iván Bonet, María Alen, Jaime Calvo Sandoval, Trinidad Pérez Evrard, Eva Revuelta Godo, Javier R. Fernández, José Antonio González Miranda-Filloy, José A. |
| author_role |
author |
| author2 |
Ferraz-Amaro, Iván Moreno-Martínez, María José Plaza, Zulema Sánchez-Alonso, Fernando Moreno-Ramos, Manuel José García-Gómez, Carmen Castañeda, Santos González-Juanatey, Carlos González-Gay, Miguel Ángel Sueiro, José L Fernández Pinto-Tasende, José A. de Rábago, Eugenia González Fernández, María J.González Codina, Ramón Huguet Yoldi, Beatriz Ramentol, Mercedes Marsal, Sara Ávila, Gabriela Alegre, Cayetano Steiner, Martina Cobo, Tatiana Muñoz, Santiago Gamero, Fernando Torón, José García Gil, María P.Moreno Mas, Antonio J. Espiño, Pilar Ros, Inmaculada Ibáñez-Barceló, Mónica Tornero, Jesús Piqueras, José A. Sanmartí, Raimon Berman, Horacio Patón, Oscar Fontseré Gutiérrez, Benjamín Fernández Abasolo, Lydia Salvador, José M.Pina Fábregas, María D. Romera, Montserrat Nolla, Joan M. Uriarte-Ecenarro, Miren Arias, Miriam García Vadillo, Jesús A.García de Vicuña, Rosario García Carmona, Eugenio Chamizo Nebro, Antonio Fernández. Ureña, Inmaculada Belmonte, María A. Irigoyen, María V. González, Olga Martínez Gómez, Rebeca Belmonte Bautista, Pastora Granados Sanz, Azucena Hernández Rey, José Santos González, Carmen O.Sánchez Bachiller, Javier Zea, Antonio Manero, Francisco J. Audera, Chesús Beltrán Medrano, Marta Pecondón, Ángela Erausquin, Celia Ojeda, Soledad Rodríguez-Lozano, Carlos BabíoHerraiz, Jesús Longo, Francisco J.López Monteagudo, Indalecio del Pino, Javier González, Ruth López Corrales, Alfonso Senabre, José M. Rosas, José C. Rotés, Isabel Moreno, Estefanía Erra, Alba Calvo, Javier Rueda, Amalia Möller, Ingrid Rodríguez, Isabel Barbadillo, Carmen Raya, Enrique Morales, Pilar Nieto, Ana Escribano, Ana Ruibal Gómez, Carmen García Expósito, Sergio Ros Nievas, Ginés Sánchez Navarro, Enrique Júdez Fernández, Manuela Sianes Pardo, Silvia Martínez Pujol, Manel GónzálezAlvarez, Beatriz Cantabrana, Alberto Bustabad, Sagrario Delgado, Esmeralda Muñoz, Alejandro Montero, Sergio Rodríguez Redondo, Javier Rivera Hernández, Teresa González Polo, Francisco J.González. Almagro, Raúl Menor Moreno, José M. Serret, Emilio Giner Méndez, Laura Cebrián Navío, María Teresa Peñalva, Teresa Pedraz Carballido, Cristina Fernández Pagán, Encarnación del Castillo, Pablo Mesa Naredo, Esperanza Cruz, Ana Turrión, Ana Gómez, Ana Pérez Sánchez, Julio Galindo, María Collantes, Eduardo Ruíz, Desireé Font, Pilar Bonilla, Gema Meseguer, Antonio López Moreno, Manuel J. Linares, Luis F. Morcillo, Mercedes Gómez, María L.González Aramburu, José M. Rivera, Natalia A. Berrizbeitia, Olaia Fernández. Park, HyeSang Riera, Manel León, Yolanda María Pérez-García, Carolina Maymó, Joan Amirall, Miriam Fiter, Jordi Melón, Julia Fernández Espadaler, Luis Belzunegui, Joaquín Bañegil, Inmaculada Díaz, César Valls, Ramón Castellví, Iván Bonet, María Alen, Jaime Calvo Sandoval, Trinidad Pérez Evrard, Eva Revuelta Godo, Javier R. Fernández, José Antonio González Miranda-Filloy, José A. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Cardiovascular risk DAS28-ESR Disease activity PREVENT Psoriatic arthritis Urate |
| topic |
Cardiovascular risk DAS28-ESR Disease activity PREVENT Psoriatic arthritis Urate |
| description |
Objective: To identify predictors of cardiovascular (CV) events in psoriatic arthritis (PsA) patients from the CARdiovascular in RheuMAtology (CARMA) project during 10 years of prospective follow-up. Methods: Between July 2010 and January 2012, 725 PsA patients were enrolled from 67 Spanish hospitals. Analyses focused on 682 patients without prior CV events at baseline. At 10-year follow-up, CV event occurrence, patient-years, and linearized event rates were evaluated. Cox regression analyses were performed, both crude and adjusted for the PREVENT-CVD score. Results: Over 6397 patient-years, 85 patients (12.46%) experienced CV events, yielding a rate of 1.33 per 100 patient-years. Patients with CV events were older (67.1 ± 11.1 vs. 56.7 ± 11.8 years, p < 0.001), more often male (68.2% vs. 51.9%, p = 0.005), and had higher frequencies of hypertension (60.0% vs. 21.8%, p < 0.001), diabetes (18.8% vs. 6.0%, p = 0.001), and dyslipidemia (56.5% vs. 29.8%, p < 0.001). They also showed greater abdominal perimeter and body mass index (p < 0.05 for both). After adjusting for PREVENT-CVD, the highest tertile of DAS28-ESR remained a significant predictor of CV events (HR 1.79; 95%CI: 1.03-3.14; p = 0.04). Urate in the highest tertile was also independently associated in the crude model (HR 1.88; 95%CI: 1.11-3.20; p = 0.02). When stratified (<6.5, 6.5-8.9, and ≥9.0 mg/dl), urate≥9.0 mg/dl was also associated with increased risk of CV events in the adjusted model (HR 3.50; 95%CI: 1.10-11.2; p = 0.02). While HAQ score in the third tertile was associated with increased CV risk in the crude analysis (HR 1.70; p = 0.04), this association did not persist after adjustment. Conclusions: Disease activity and elevated urate levels independently predict CV events in PsA, highlighting their value as markers of CV risk beyond traditional factors captured by the PREVENT-CVD score. |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 2026-04-01 2026 2026-04-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.13003/26596 |
| url |
https://hdl.handle.net/20.500.13003/26596 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier BV |
| publisher.none.fl_str_mv |
Elsevier BV |
| dc.source.none.fl_str_mv |
reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears |
| instname_str |
Conselleria de Salut i Consum del Govern de les Illes Balears |
| reponame_str |
Docusalut |
| collection |
Docusalut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869410385911611392 |
| spelling |
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohortLlorca, JavierFerraz-Amaro, IvánMoreno-Martínez, María JoséPlaza, ZulemaSánchez-Alonso, FernandoMoreno-Ramos, Manuel JoséGarcía-Gómez, CarmenCastañeda, SantosGonzález-Juanatey, CarlosGonzález-Gay, Miguel ÁngelSueiro, José L FernándezPinto-Tasende, José A.de Rábago, Eugenia GonzálezFernández, María J.GonzálezCodina, Ramón HuguetYoldi, BeatrizRamentol, MercedesMarsal, SaraÁvila, GabrielaAlegre, CayetanoSteiner, MartinaCobo, TatianaMuñoz, SantiagoGamero, FernandoTorón, José GarcíaGil, María P.MorenoMas, Antonio J.Espiño, PilarRos, InmaculadaIbáñez-Barceló, MónicaTornero, JesúsPiqueras, José A.Sanmartí, RaimonBerman, HoracioPatón, Oscar FontseréGutiérrez, Benjamín FernándezAbasolo, LydiaSalvador, José M.PinaFábregas, María D.Romera, MontserratNolla, Joan M.Uriarte-Ecenarro, MirenArias, Miriam GarcíaVadillo, Jesús A.Garcíade Vicuña, Rosario GarcíaCarmona, Eugenio ChamizoNebro, Antonio Fernández.Ureña, InmaculadaBelmonte, María A.Irigoyen, María V.González, Olga MartínezGómez, Rebeca BelmonteBautista, Pastora GranadosSanz, Azucena HernándezRey, José SantosGonzález, Carmen O.SánchezBachiller, JavierZea, AntonioManero, Francisco J.Audera, Chesús BeltránMedrano, MartaPecondón, ÁngelaErausquin, CeliaOjeda, SoledadRodríguez-Lozano, CarlosBabíoHerraiz, JesúsLongo, Francisco J.LópezMonteagudo, Indaleciodel Pino, JavierGonzález, Ruth LópezCorrales, AlfonsoSenabre, José M.Rosas, José C.Rotés, IsabelMoreno, EstefaníaErra, AlbaCalvo, JavierRueda, AmaliaMöller, IngridRodríguez, IsabelBarbadillo, CarmenRaya, EnriqueMorales, PilarNieto, AnaEscribano, Ana RuibalGómez, Carmen GarcíaExpósito, Sergio RosNievas, Ginés SánchezNavarro, Enrique JúdezFernández, Manuela SianesPardo, Silvia MartínezPujol, ManelGónzálezAlvarez, BeatrizCantabrana, AlbertoBustabad, SagrarioDelgado, EsmeraldaMuñoz, AlejandroMontero, Sergio RodríguezRedondo, Javier RiveraHernández, Teresa GonzálezPolo, Francisco J.González.Almagro, Raúl MenorMoreno, José M.Serret, Emilio GinerMéndez, Laura CebriánNavío, María TeresaPeñalva, Teresa PedrazCarballido, Cristina FernándezPagán, Encarnacióndel Castillo, Pablo MesaNaredo, EsperanzaCruz, AnaTurrión, AnaGómez, Ana PérezSánchez, JulioGalindo, MaríaCollantes, EduardoRuíz, DesireéFont, PilarBonilla, GemaMeseguer, Antonio LópezMoreno, Manuel J.Linares, Luis F.Morcillo, MercedesGómez, María L.GonzálezAramburu, José M.Rivera, Natalia A.Berrizbeitia, Olaia Fernández.Park, HyeSangRiera, ManelLeón, Yolanda MaríaPérez-García, CarolinaMaymó, JoanAmirall, MiriamFiter, JordiMelón, Julia FernándezEspadaler, LuisBelzunegui, JoaquínBañegil, InmaculadaDíaz, CésarValls, RamónCastellví, IvánBonet, MaríaAlen, Jaime CalvoSandoval, Trinidad PérezEvrard, Eva RevueltaGodo, Javier R.Fernández, José Antonio GonzálezMiranda-Filloy, José A.Cardiovascular riskDAS28-ESRDisease activityPREVENTPsoriatic arthritisUrateObjective: To identify predictors of cardiovascular (CV) events in psoriatic arthritis (PsA) patients from the CARdiovascular in RheuMAtology (CARMA) project during 10 years of prospective follow-up. Methods: Between July 2010 and January 2012, 725 PsA patients were enrolled from 67 Spanish hospitals. Analyses focused on 682 patients without prior CV events at baseline. At 10-year follow-up, CV event occurrence, patient-years, and linearized event rates were evaluated. Cox regression analyses were performed, both crude and adjusted for the PREVENT-CVD score. Results: Over 6397 patient-years, 85 patients (12.46%) experienced CV events, yielding a rate of 1.33 per 100 patient-years. Patients with CV events were older (67.1 ± 11.1 vs. 56.7 ± 11.8 years, p < 0.001), more often male (68.2% vs. 51.9%, p = 0.005), and had higher frequencies of hypertension (60.0% vs. 21.8%, p < 0.001), diabetes (18.8% vs. 6.0%, p = 0.001), and dyslipidemia (56.5% vs. 29.8%, p < 0.001). They also showed greater abdominal perimeter and body mass index (p < 0.05 for both). After adjusting for PREVENT-CVD, the highest tertile of DAS28-ESR remained a significant predictor of CV events (HR 1.79; 95%CI: 1.03-3.14; p = 0.04). Urate in the highest tertile was also independently associated in the crude model (HR 1.88; 95%CI: 1.11-3.20; p = 0.02). When stratified (<6.5, 6.5-8.9, and ≥9.0 mg/dl), urate≥9.0 mg/dl was also associated with increased risk of CV events in the adjusted model (HR 3.50; 95%CI: 1.10-11.2; p = 0.02). While HAQ score in the third tertile was associated with increased CV risk in the crude analysis (HR 1.70; p = 0.04), this association did not persist after adjustment. Conclusions: Disease activity and elevated urate levels independently predict CV events in PsA, highlighting their value as markers of CV risk beyond traditional factors captured by the PREVENT-CVD score.Elsevier BV20262026-04-0120262026-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/26596reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/265962026-06-22T12:44:07Z |
| score |
15.811543 |