Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family

Antimicrobial susceptibility testing is necessary to carry out antimicrobial stewardship but a limited number of drugs belonging to each antimicrobial family has to be tested for techni- cal limitations and economic resources. In this study, we have determined the minimal inhibitory concentration, u...

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Detalhes bibliográficos
Autores: Vilaró, Anna, Novell, Elena, Tarancón, Vicens, Balielles, Jordi, Migura-García, Lourdes, Fraile Sauce, Lorenzo José
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/83363
Acesso em linha:https://doi.org/10.3390/antibiotics11050638
http://hdl.handle.net/10459.1/83363
Access Level:acceso abierto
Palavra-chave:Antimicrobial
Susceptibility testing
MIC
Porcine bacterial pathogen
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spelling Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial familyVilaró, AnnaNovell, ElenaTarancón, VicensBalielles, JordiMigura-García, LourdesFraile Sauce, Lorenzo JoséAntimicrobialSusceptibility testingMICPorcine bacterial pathogenAntimicrobial susceptibility testing is necessary to carry out antimicrobial stewardship but a limited number of drugs belonging to each antimicrobial family has to be tested for techni- cal limitations and economic resources. In this study, we have determined the minimal inhibitory concentration, using microdilution following international standards (CLSI), for 490 Actinobacillus pleuropneumoniae, 285 Pasteurella multocida, 73 Bordetella bronchiseptica, 398 Streptococcus suis and 1571 Escherichia coli strains from clinical cases collected in Spain between 2018 and 2020. The an- timicrobial susceptibility pattern was deciphered using a principal component analysis for each bacterium and a matrix correlation (high > 0.8, medium 0.5-0.8 and low < 0.5) was obtained for each pair of antimicrobials. No significant associations were observed between MIC patterns for different antimicrobial families, suggesting that co-selection mechanisms are not generally present in these porcine pathogens. However, a high correlation was observed between the fluroquinolones (mar- bofloxacin and enrofloxacin) for all mentioned pathogens and for ceftiofur and cefquinome for E. coli and S. suis. Moreover, a significant association was also observed for tetracyclines (doxycycline and oxytetracycline) and B. bronchiseptica and tildipirosin/tulathromycin for P. multocida. These results suggest that generally, a representative drug per antimicrobial class cannot be selected, however, for some drug-bug combinations, MIC values from one representative drug could be extrapolated to the whole antimicrobial family.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/antibiotics11050638http://hdl.handle.net/10459.1/83363reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antibiotics11050638Antibiotics-Basel, 2022, vol. 11, núm. 638, p. 1-15cc-by (c) Vilaró et al., 2022info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/833632026-05-29T05:05:01Z
dc.title.none.fl_str_mv Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
title Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
spellingShingle Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
Vilaró, Anna
Antimicrobial
Susceptibility testing
MIC
Porcine bacterial pathogen
title_short Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
title_full Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
title_fullStr Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
title_full_unstemmed Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
title_sort Antimicrobial Susceptibility Testing of Porcine Bacterial Pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family
dc.creator.none.fl_str_mv Vilaró, Anna
Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author Vilaró, Anna
author_facet Vilaró, Anna
Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author_role author
author2 Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antimicrobial
Susceptibility testing
MIC
Porcine bacterial pathogen
topic Antimicrobial
Susceptibility testing
MIC
Porcine bacterial pathogen
description Antimicrobial susceptibility testing is necessary to carry out antimicrobial stewardship but a limited number of drugs belonging to each antimicrobial family has to be tested for techni- cal limitations and economic resources. In this study, we have determined the minimal inhibitory concentration, using microdilution following international standards (CLSI), for 490 Actinobacillus pleuropneumoniae, 285 Pasteurella multocida, 73 Bordetella bronchiseptica, 398 Streptococcus suis and 1571 Escherichia coli strains from clinical cases collected in Spain between 2018 and 2020. The an- timicrobial susceptibility pattern was deciphered using a principal component analysis for each bacterium and a matrix correlation (high > 0.8, medium 0.5-0.8 and low < 0.5) was obtained for each pair of antimicrobials. No significant associations were observed between MIC patterns for different antimicrobial families, suggesting that co-selection mechanisms are not generally present in these porcine pathogens. However, a high correlation was observed between the fluroquinolones (mar- bofloxacin and enrofloxacin) for all mentioned pathogens and for ceftiofur and cefquinome for E. coli and S. suis. Moreover, a significant association was also observed for tetracyclines (doxycycline and oxytetracycline) and B. bronchiseptica and tildipirosin/tulathromycin for P. multocida. These results suggest that generally, a representative drug per antimicrobial class cannot be selected, however, for some drug-bug combinations, MIC values from one representative drug could be extrapolated to the whole antimicrobial family.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/antibiotics11050638
http://hdl.handle.net/10459.1/83363
url https://doi.org/10.3390/antibiotics11050638
http://hdl.handle.net/10459.1/83363
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antibiotics11050638
Antibiotics-Basel, 2022, vol. 11, núm. 638, p. 1-15
dc.rights.none.fl_str_mv cc-by (c) Vilaró et al., 2022
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Vilaró et al., 2022
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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