Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy

A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequ...

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Autores: Simeonidis, Konstantinos, Kaprara, Efthimia, Rivera Gil, Pilar, 1976-, Xu, Ruixue, Teran, Francisco J., Kokkinos, Evgenios, Mitropoulos, Athanassios, Maniotis, Nikolaos, Balcells, Lluis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48331
Acceso en línea:http://hdl.handle.net/10230/48331
http://dx.doi.org/10.3390/nano11071796
Access Level:acceso abierto
Palabra clave:Fe3O4
Cell internalization
Continuous flow synthesis
Drug delivery
Layered double hydroxide
Magnetic hyperthermia
Nanocomposite
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spelling Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapySimeonidis, KonstantinosKaprara, EfthimiaRivera Gil, Pilar, 1976-Xu, RuixueTeran, Francisco J.Kokkinos, EvgeniosMitropoulos, AthanassiosManiotis, NikolaosBalcells, LluisFe3O4Cell internalizationContinuous flow synthesisDrug deliveryLayered double hydroxideMagnetic hyperthermiaNanocompositeA magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe2+, Fe3+) and Mg2+/Al3+ nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe3O4/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.The project was financially supported by Stavros Niarchos Foundation and Eastern Macedonia and Thrace Institute of Technology fellowships for assisting young scientists in prototyping innovative products by using cutting-edge technology. Specific measurements received funding from the EU-H2020 research and innovation programme under grant agreement No. 654360 having benefitted from the access provided by ICMAB-CSIC and Universitat Autonoma de Barcelona in Bellaterra-Barcelona within the framework of the NFFA-Europe Transnational Access Activity. Authors would like to thank Anna Esther Carrillo for the experimental assistance during SEM observations and Bernat Bozzo for the support in SQUID measurements. This work was partially funded by Spanish Ministry of Science, Innovation and Universities (MAT2017-85617-R, SEV-2016-0686, RED2018-102626-T) and Comunidad de Madrid (NANOMAGCOST). COST Actions CA17115 (MyWave), and CA17140 (Nano2Clinic) are also acknowledged. The UPF acknowledges the Ministry of Science, Innovation and Universities (MICINN) and the AEI (RYC-2012-10059, MDM-2014-0370-04, CTQ2013-45433-PFEDER], MAT2016-75362-C3-2-R, AEI-SAF2015-73052-EXP) and the AGAUR (2017 SGR 1054) for financial support.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48331http://dx.doi.org/10.3390/nano11071796reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNanomaterials (Basel). 2021;11(7):1796info:eu-repo/grantAgreement/EC/H2020/654360© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/483312026-06-12T07:21:37Z
dc.title.none.fl_str_mv Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
title Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
spellingShingle Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
Simeonidis, Konstantinos
Fe3O4
Cell internalization
Continuous flow synthesis
Drug delivery
Layered double hydroxide
Magnetic hyperthermia
Nanocomposite
title_short Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
title_full Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
title_fullStr Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
title_full_unstemmed Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
title_sort Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
dc.creator.none.fl_str_mv Simeonidis, Konstantinos
Kaprara, Efthimia
Rivera Gil, Pilar, 1976-
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
author Simeonidis, Konstantinos
author_facet Simeonidis, Konstantinos
Kaprara, Efthimia
Rivera Gil, Pilar, 1976-
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
author_role author
author2 Kaprara, Efthimia
Rivera Gil, Pilar, 1976-
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fe3O4
Cell internalization
Continuous flow synthesis
Drug delivery
Layered double hydroxide
Magnetic hyperthermia
Nanocomposite
topic Fe3O4
Cell internalization
Continuous flow synthesis
Drug delivery
Layered double hydroxide
Magnetic hyperthermia
Nanocomposite
description A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe2+, Fe3+) and Mg2+/Al3+ nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe3O4/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48331
http://dx.doi.org/10.3390/nano11071796
url http://hdl.handle.net/10230/48331
http://dx.doi.org/10.3390/nano11071796
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomaterials (Basel). 2021;11(7):1796
info:eu-repo/grantAgreement/EC/H2020/654360
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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